KEGG   ORTHOLOGY: K15988Help
Entry
K15988                      KO                                     

Name
tylG
Definition
tylactone synthase
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15988  tylG; tylactone synthase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15988  tylG; tylactone synthase
BRITE hierarchy
Other DBs
RN: R06448
Genes
AG: AAB66504(tylG1) AAB66505(tylG2) AAB66506(tylG3) AAB66507(tylG4) AAB66508(tylG5)
TaxonomyKoalaUniProt
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
  Authors
Hertweck C
  Title
The biosynthetic logic of polyketide diversity.
  Journal
Angew Chem Int Ed Engl 48:4688-716 (2009)
DOI:10.1002/anie.200806121

KEGG   REACTION: R06448Help
Entry
R06448                      Reaction                               

Definition
5 Methylmalonyl-CoA + 2 Malonyl-CoA + (2S)-Ethylmalonyl-CoA + 7 NADPH + 7 H+ <=> 8 CoA + Tylactone + 8 CO2 + 3 H2O + 7 NADP+
Equation
5 C02557 + 2 C00083 + C18026 + 7 C00005 + 7 C00080 <=> 8 C00010 + C12000 + 8 C00011 + 3 C00001 + 7 C00006
Comment
tylactone synthase,TylG1-5
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557  C00010_C18026
RC02829  C02557_C12000
RC02910  C02557_C12000
RC02911  C00083_C12000
RC02912  C00083_C12000
RC02914  C02557_C12000
RC02917  C02557_C12000
RC02919  C02557_C12000
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15988  tylactone synthase

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