KEGG   ORTHOLOGY: K15993
Entry
K15993            Tight     KO                                     

Name
tylN
Definition
O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.317  O-mycaminosyltylonolide 6-deoxyallosyltransferase
     K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
Other DBs
RN: R06451
CAZy: GT1
Genes
AG: CAA06512(tylN)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:9651492
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene 214:95-100 (1998)
DOI:10.1016/S0378-1119(98)00210-8
  Sequence

KEGG   ENZYME: 2.4.1.317
Entry
EC 2.4.1.317                Enzyme                                 

Name
O-mycaminosyltylonolide 6-deoxyallosyltransferase;
tylN (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-alpha-D-allosyltransferase
Reaction(IUBMB)
5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin [RN:R06451]
Reaction(KEGG)
R06451
Substrate
5-O-beta-D-mycaminosyltylonolide [CPD:C12002];
dTDP-6-deoxy-alpha-D-allose [CPD:C11912]
Product
dTDP [CPD:C00363];
demethyllactenocin [CPD:C12003]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.317 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15993  O-mycaminosyltylonolide 6-deoxyallosyltransferase
Reference
1  [PMID:9651492]
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene 214:95-100 (1998)
DOI:10.1016/S0378-1119(98)00210-8
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.317
IUBMB Enzyme Nomenclature: 2.4.1.317
ExPASy - ENZYME nomenclature database: 2.4.1.317
BRENDA, the Enzyme Database: 2.4.1.317

KEGG   REACTION: R06451
Entry
R06451                      Reaction                               

Name
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-beta-D-allosyltransferase
Definition
5-O-beta-D-Mycaminosyltylonolide + dTDP-6-deoxy-D-allose <=> Demethyllactenocin + dTDP
Equation
Reaction class
RC00005  C00363_C11912
RC00059  C12002_C12003
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15993  O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317]
Other DBs
RHEA: 15360

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