KEGG   ORTHOLOGY: K15994
Entry
K15994            Tight     KO                                     

Name
tylCV
Definition
demethyllactenocin mycarosyltransferase [EC:2.4.1.318]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15994  tylCV; demethyllactenocin mycarosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15994  tylCV; demethyllactenocin mycarosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.318  demethyllactenocin mycarosyltransferase
     K15994  tylCV; demethyllactenocin mycarosyltransferase
Other DBs
RN: R06452
CAZy: GT1
Genes
AG: AAD41824(tylCV)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence

KEGG   ENZYME: 2.4.1.318
Entry
EC 2.4.1.318                Enzyme                                 

Name
demethyllactenocin mycarosyltransferase;
tylCV (gene name);
tylC5 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase
Reaction(IUBMB)
dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin [RN:R06452]
Reaction(KEGG)
R06452
Substrate
dTDP-beta-L-mycarose [CPD:C11916];
demethyllactenocin [CPD:C12003]
Product
dTDP [CPD:C00363];
demethylmacrocin [CPD:C02400]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.318 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15994  demethyllactenocin mycarosyltransferase
Reference
1  [PMID:10658660]
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.318
IUBMB Enzyme Nomenclature: 2.4.1.318
ExPASy - ENZYME nomenclature database: 2.4.1.318
BRENDA, the Enzyme Database: 2.4.1.318

KEGG   REACTION: R06452
Entry
R06452                      Reaction                               

Name
dTDP-L-mycarose:demethyllactenocin 4'-O-alpha-mycarosyltransferase
Definition
Demethyllactenocin + dTDP-L-mycarose <=> Demethylmacrocin + dTDP
Equation
Reaction class
RC00005  C00363_C11916
RC00049  C02400_C12003
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15994  demethyllactenocin mycarosyltransferase [EC:2.4.1.318]
Other DBs
RHEA: 14652

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