 | | ORTHOLOGY: K16006 | |
| Entry |
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| Symbol |
pikC, CYP107L
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| Name |
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| Pathway |
| map00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| map01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00776 | Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin |
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| Reaction |
| R06462 | 10-deoxymethymycin,reduced ferredoxin:oxygen oxidoreductase (neomethymycin-forming) |
| R06463 | 10-deoxymethymycin,reduced ferredoxin:oxygen oxidoreductase (methymycin-forming) |
| R06464 | narbomycin,reduced ferredoxin:oxygen oxidoreductase (pikromycin-forming) |
| R10626 | narbomycin,reduced ferredoxin:oxygen oxidoreductase (neopikromycin-forming) |
| R10627 | narbomycin,reduced ferredoxin:oxygen oxidoreductase (novapikromyin-forming) |
| R10628 | 10-deoxymethymycin,reduced ferredoxin:oxygen oxidoreductase (novamethymycin-forming) |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
K16006 pikC, CYP107L; pikromycin synthase
00522 Biosynthesis of 12-, 14- and 16-membered macrolides
K16006 pikC, CYP107L; pikromycin synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K16006 pikC, CYP107L; pikromycin synthase
00199 Cytochrome P450
K16006 pikC, CYP107L; pikromycin synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.33 pikromycin synthase
K16006 pikC, CYP107L; pikromycin synthase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
Oxygenase
K16006 pikC, CYP107L; pikromycin synthase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, bacteria type
CYP107 family
K16006 pikC, CYP107L; pikromycin synthase
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| Other DBs |
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| Genes |
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| Reference |
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| Authors |
Xue Y, Wilson D, Zhao L, Liu H, Sherman DH |
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| Title |
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM |
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| Title |
The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. |
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| Journal |
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| Reference |
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| Authors |
Li S, Ouellet H, Sherman DH, Podust LM |
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| Title |
Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae. |
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