KEGG   ORTHOLOGY: K16007Help
Entry
K16007                      KO                                     

Name
oleA
Definition
8,8a-deoxyoleandolide synthase
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16007  oleA; 8,8a-deoxyoleandolide synthase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16007  oleA; 8,8a-deoxyoleandolide synthase
BRITE hierarchy
Other DBs
RN: R06453
Genes
AG: AAA19695(oleAIII) AAF82408(oleAI) AAF82409(oleAII)
TaxonomyKoalaUniProt
Reference
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
  Sequence
Reference
PMID:8107683
  Authors
Swan DG, Rodriguez AM, Vilches C, Mendez C, Salas JA
  Title
Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.
  Journal
Mol Gen Genet 242:358-62 (1994)
DOI:10.1007/BF00280426
  Sequence

KEGG   REACTION: R06453Help
Entry
R06453                      Reaction                               

Definition
Malonyl-CoA + 6 Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-Deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+
Equation
C00083 + 6 C02557 + 6 C00005 + 6 C00080 <=> C11989 + 7 C00010 + 7 C00011 + C00001 + 6 C00006
Comment
8,8a-deoxyoleandolide synthase,OleA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557
RC02826  C02557_C11989
RC02828  C02557_C11989
RC02829  C02557_C11989
RC02830  C02557_C11989
RC02831  C02557_C11989
RC02918  C00083_C11989
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16007  8,8a-deoxyoleandolide synthase

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