KEGG   ORTHOLOGY: K16008Help
Entry
K16008                      KO                                     

Name
oleP, CYP107D
Definition
cytochrome P450 monooxygenase OleP
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16008  oleP, CYP107D; cytochrome P450 monooxygenase OleP
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16008  oleP, CYP107D; cytochrome P450 monooxygenase OleP
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K16008  oleP, CYP107D; cytochrome P450 monooxygenase OleP
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP107 family
   K16008  oleP, CYP107D; cytochrome P450 monooxygenase OleP
BRITE hierarchy
Other DBs
RN: R06454
COG: COG2124
Genes
AG: AAA92553(oleP)
TaxonomyKoalaUniProt
Reference
PMID:7737473
  Authors
Rodriguez AM, Olano C, Mendez C, Hutchinson CR, Salas JA
  Title
A cytochrome P450-like gene possibly involved in oleandomycin biosynthesis by Streptomyces antibioticus.
  Journal
FEMS Microbiol Lett 127:117-20 (1995)
DOI:10.1111/j.1574-6968.1995.tb07459.x
  Sequence
Reference
  Authors
Gaisser S, Lill R, Staunton J, Mendez C, Salas J, Leadlay PF
  Title
Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 44:771-81 (2002)
DOI:10.1046/j.1365-2958.2002.02910.x

KEGG   REACTION: R06454Help
Entry
R06454                      Reaction                               

Definition
8,8a-Deoxyoleandolide + 2 NADPH + 2 H+ + 2 Oxygen <=> Oleandolide + 2 NADP+ + 3 H2O
Equation
C11989 + 2 C00005 + 2 C00080 + 2 C00007 <=> C11990 + 2 C00006 + 3 C00001
Comment
cytochrome P450 monooxygenase,OleP
Reaction class
RC00001  C00005_C00006
RC01524  C11989_C11990
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16008  cytochrome P450 monooxygenase OleP

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