KEGG   ORTHOLOGY: K16010Help
Entry
K16010                      KO                                     

Name
oleGI
Definition
desosaminyltransferase OleGI
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16010  oleGI; desosaminyltransferase OleGI
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16010  oleGI; desosaminyltransferase OleGI
BRITE hierarchy
Other DBs
RN: R06457
CAZy: GT1
Genes
AG: CAA05641(oleGI)
TaxonomyKoalaUniProt
Reference
PMID:9749673
  Authors
Olano C, Rodriguez AM, Michel JM, Mendez C, Raynal MC, Salas JA
  Title
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.
  Journal
Mol Gen Genet 259:299-308 (1998)
DOI:10.1007/s004380050816
  Sequence
Reference
  Authors
Doumith M, Legrand R, Lang C, Salas JA, Raynal MC
  Title
Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives.
  Journal
Mol Microbiol 34:1039-48 (1999)
DOI:10.1046/j.1365-2958.1999.01666.x

KEGG   REACTION: R06457Help
Entry
R06457                      Reaction                               

Definition
L-Oleandrosyl-oleandolide + dTDP-D-desosamine <=> Oleandomycin + dTDP
Equation
Comment
desosaminyltransferase,OleGI
Reaction class
RC00005  C00363_C11911
RC00049  C01946_C11992
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16010  desosaminyltransferase OleGI

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