KEGG   ORTHOLOGY: K16018Help
Entry
K16018                      KO                                     

Name
rifN, asm22
Definition
kanosamine 6-kinase [EC:2.7.1.179]
Pathway
ko01051  Biosynthesis of ansamycins
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01051 Biosynthesis of ansamycins
    K16018  rifN, asm22; kanosamine 6-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.179  kanosamine kinase
     K16018  rifN, asm22; kanosamine 6-kinase
BRITE hierarchy
Other DBs
RN: R06588
Genes
SVL: Strvi_5366
SRW: TUE45_00083(rifN)
SLE: cxmN(cxmN)
SPAV: Spa2297_32600
SAUO: BV401_10580
SPUN: BFF78_27090
SMAL: SMALA_1353
FRA: Francci3_0432
FRE: Franean1_1662
FAL: FRAAL0917
SEN: SACE_2869(rifN)
AMD: AMED_0630(rifN)
AMN: RAM_03220
AMM: AMES_0628(rifN)
AMZ: B737_0629(rifN)
AMI: Amir_3285
SAQ: Sare_1275
MIL: ML5_5917
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Arakawa K, Muller R, Mahmud T, Yu TW, Floss HG
  Title
Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.
  Journal
J Am Chem Soc 124:10644-5 (2002)
DOI:10.1021/ja0206339
  Sequence
[amn:RAM_03220]

KEGG   ENZYME: 2.7.1.179Help
Entry
EC 2.7.1.179                Enzyme                                 

Name
kanosamine kinase;
rifN (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:kanosamine 6-phosphotransferase
Reaction(IUBMB)
ATP + kanosamine = ADP + kanosamine 6-phosphate [RN:R06588]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
kanosamine [CPD:C12212]
Product
ADP [CPD:C00008];
kanosamine 6-phosphate [CPD:C12213]
Comment
The enzyme from the bacterium Amycolatopsis mediterranei is specific for kanosamine.
History
EC 2.7.1.179 created 2013
Pathway
ec01051  Biosynthesis of ansamycins
ec01130  Biosynthesis of antibiotics
Orthology
K16018  kanosamine 6-kinase
Genes
SVL: Strvi_5366
SRW: TUE45_00083(rifN)
SLE: cxmN(cxmN)
SPAV: Spa2297_32600
SAUO: BV401_10580
SPUN: BFF78_27090
SMAL: SMALA_1353
FRA: Francci3_0432
FRE: Franean1_1662
FAL: FRAAL0917
SEN: SACE_2869(rifN)
AMD: AMED_0630(rifN)
AMN: RAM_03220
AMM: AMES_0628(rifN)
AMZ: B737_0629(rifN)
AMI: Amir_3285
SAQ: Sare_1275
MIL: ML5_5917
 » show all
Taxonomy
Reference
1  [PMID:12207505]
  Authors
Arakawa K, Muller R, Mahmud T, Yu TW, Floss HG.
  Title
Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.
  Journal
J Am Chem Soc 124:10644-5 (2002)
DOI:10.1021/ja0206339
  Sequence
[amn:RAM_03220]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.179
IUBMB Enzyme Nomenclature: 2.7.1.179
ExPASy - ENZYME nomenclature database: 2.7.1.179
BRENDA, the Enzyme Database: 2.7.1.179

KEGG   REACTION: R06588Help
Entry
R06588                      Reaction                               

Name
ATP:kanosamine 6-phosphotransferase
Definition
ATP + Kanosamine <=> ADP + Kanosamine 6-phosphate
Equation
Comment
kanosamine 6-kinase, RifN Asm22
Reaction class
RC00002  C00002_C00008
RC00017  C12212_C12213
Enzyme
Pathway
rn01051  Biosynthesis of ansamycins
rn01130  Biosynthesis of antibiotics
Orthology
K16018  kanosamine 6-kinase [EC:2.7.1.179]
Other DBs
RHEA: 35754

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