KEGG   ORTHOLOGY: K16035Help
Entry
K16035                      KO                                     

Name
asm21
Definition
7-O-carbamoyltransferase [EC:2.1.3.-]
Pathway
ko01051  Biosynthesis of ansamycins
ko01052  Type I polyketide structures
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16035  asm21; 7-O-carbamoyltransferase
   01051 Biosynthesis of ansamycins
    K16035  asm21; 7-O-carbamoyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.-  
     K16035  asm21; 7-O-carbamoyltransferase
BRITE hierarchy
Other DBs
RN: R09853 R09858
Genes
SCB: SCAB_84021
SVL: Strvi_5872
AMI: Amir_3193 Amir_3283
TaxonomyKoalaUniProt
Reference
  Authors
Li Y, Zhao P, Kang Q, Ma J, Bai L, Deng Z
  Title
Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.
  Journal
Chem Biol 18:1571-80 (2011)
DOI:10.1016/j.chembiol.2011.11.007
Reference
  Authors
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG
  Title
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
  Journal
J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (5)   
   KEGG GENES (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (4)   
Literature (3)   
   PubMed (3)   
All databases (24)   

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KEGG   REACTION: R09853Help
Entry
R09853                      Reaction                               

Name
carbamoyl-phosphate:20-O-methyl-19-chloroproansamitocin carbamoyltransferase
Definition
20-O-Methyl-19-chloroproansamitocin + Carbamoyl phosphate <=> N-Demethyl-desepoxymaytansinol + Orthophosphate
Equation
Reaction class
RC02840  C20135_C20136
Enzyme
2.1.3.-
Pathway
rn01051  Biosynthesis of ansamycins
rn01130  Biosynthesis of antibiotics
Orthology
K16035  7-O-carbamoyltransferase [EC:2.1.3.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG RCLASS (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (15)   

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