KEGG   ORTHOLOGY: K16036Help
Entry
K16036                      KO                                     

Name
asm19
Definition
3-O-acyltransferase
Pathway
ko01051  Biosynthesis of ansamycins
ko01052  Type I polyketide structures
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16036  asm19; 3-O-acyltransferase
   01051 Biosynthesis of ansamycins
    K16036  asm19; 3-O-acyltransferase
BRITE hierarchy
Other DBs
RN: R09854
Genes
AMI: Amir_3191
APRE: CNX65_16235
TaxonomyKoalaUniProt
Reference
  Authors
Moss SJ, Bai L, Toelzer S, Carroll BJ, Mahmud T, Yu TW, Floss HG
  Title
Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate.
  Journal
J Am Chem Soc 124:6544-5 (2002)
DOI:10.1021/ja020214b
Reference
  Authors
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG
  Title
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
  Journal
J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199
  Sequence

KEGG   REACTION: R09854Help
Entry
R09854                      Reaction                               

Definition
N-Demethyl-desepoxymaytansinol + 2-Methylpropanoyl-CoA <=> N-Demethyl-desepoxyansamitocin P-3 + CoA
Equation
Reaction class
RC00004  C00010_C00630
RC00055  C20136_C20137
Pathway
rn01051  Biosynthesis of ansamycins
rn01130  Biosynthesis of antibiotics
Orthology
K16036  3-O-acyltransferase

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