KEGG   ORTHOLOGY: K16038Help
Entry
K16038                      KO                                     

Name
asm10
Definition
N-methyltransferase [EC:2.1.1.-]
Pathway
ko01051  Biosynthesis of ansamycins
ko01052  Type I polyketide structures
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16038  asm10; N-methyltransferase
   01051 Biosynthesis of ansamycins
    K16038  asm10; N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K16038  asm10; N-methyltransferase
BRITE hierarchy
Other DBs
RN: R09856
Genes
AMI: Amir_3182
APRE: CNX65_16190
TaxonomyKoalaUniProt
Reference
  Authors
Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG
  Title
N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.
  Journal
Chembiochem 12:1759-66 (2011)
DOI:10.1002/cbic.201100062
Reference
  Authors
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG
  Title
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
  Journal
J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199
  Sequence

KEGG   REACTION: R09856Help
Entry
R09856                      Reaction                               

Name
S-adenosyl-L-methionine:N-demethylansamitocin-P-3 N-methyltransferase
Definition
S-Adenosyl-L-methionine + N-Demethylansamitocin P-3 <=> S-Adenosyl-L-homocysteine + Ansamitocin P-3
Equation
Reaction class
RC00003  C00019_C00021
RC02842  C12045_C20138
Enzyme
2.1.1.-
Pathway
rn01051  Biosynthesis of ansamycins
rn01130  Biosynthesis of antibiotics
Orthology
K16038  N-methyltransferase [EC:2.1.1.-]

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