KEGG ORTHOLOGY: K16045

ORTHOLOGY: K16045

Entry

K16045                      KO

Symbol

hsd

Name

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Pathway

map00984

Steroid degradation

map01120

Microbial metabolism in diverse environments

Reaction

R09920

cholesterol:NAD+ 3-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16045  hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     K16045  hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     K16045  hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Other DBs

COG:

COG0451

GO:	0003854 0004769

Genes

ENW:	MJO57_19210

EMP:	EZMO1_1200(nsdHL)

PWU:	A8O14_06055

MTU:

Rv1106c

MTV:	RVBD_1106c

MTC:

MT1137

MRA:

MRA_1117

MTF:	TBFG_11128

MTB:	TBMG_02877

MTK:	TBSG_02893

MTZ:	TBXG_002857

MTG:	MRGA327_06925

MTI:	MRGA423_06915

MTE:	CCDC5079_1022

MTUR:

CFBS_1174

MTL:	CCDC5180_1014

MTO:	MTCTRI2_1136

MTD:

UDA_1106c

MTN:	ERDMAN_1239

MTJ:	J112_05975

MTUB:

MT7199_1133

MTUC:

J113_07785

MTUE:

J114_05980

MTX:	M943_05820

MTUH:

MTUL:

MTUT:

MTUU:

MTQ:	HKBS1_1174

MBO:	BQ2027_MB1136C

MBB:

BCG_1166c

MBT:

JTY_1139

MBM:	BCGMEX_1138c

MBK:	K60_011910

MBX:

BCGT_0934

MAF:

MAF_11210

MMIC:

RN08_1242

MCE:	MCAN_11161

MCQ:	BN44_11231

MCV:	BN43_30163

MCX:	BN42_20954

MCZ:	BN45_30150

MORY:

MLE:

MLB:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MAVM:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MSER:

MSA:	Mycsm_05045

MUL:

MUL_0172

MMI:

MMAR_4359

MMAE:

MMARE11_41790

MLI:	MULP_04570

MPSE:

MSHO:

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_07985

MYV:	G155_22700

MYE:	AB431_06460

MHAD:

B586_07090

MDX:	BTO20_08365

MSHG:

MSG_03923

MFJ:	MFLOJ_47450

MSTO:

MSTO_51430

MSIM:

MSIM_37390

MSAK:

MSAS_22240

MKU:	I2456_20620

MLW:	MJO58_21440

MXE:	MYXE_14010

MNV:	MNVI_06140

MPAG:

C0J29_23965

MNM:	MNVM_07790

MGOR:

MCOO:

MBAI:

MSEO:

MHEK:

MGAU:

MLJ:	MLAC_06830

MBRD:

MSHJ:

MMAM:

MSPG:

MOT:	LTS72_03400

MLM:	MLPF_2463(hsd)

MPAA:

MKK62_05735

MKY:	IWGMT90018_50180

MADI:

A7U43_09340

MWU:	PT015_11765

MYW:	BVC93_17935

MYJ:	BCA37_24750

MSM:	MSMEG_5228

MSG:	MSMEI_5091

MSB:	LJ00_25860

MSN:	LI99_25865

MSH:	LI98_25870

MVA:

Mvan_4635

MGI:

Mflv_2075

MSP:	Mspyr1_14990

MCB:	Mycch_4050

MNE:	D174_21420

MYN:	MyAD_21005

MFT:	XA26_46570

MPHL:

MPHLCCUG_04229

MVQ:

MYVA_4444

MLL:	B1R94_06430

MRH:	MycrhN_3550

MTHN:

4412656_03537

MHAS:

MHAS_03213

MDU:	MDUV_00690

MCHT:

MAUU:

MMAG:

MMOR:

MFX:	MFAL_37920

MAIC:

MAIC_43720

MIJ:	MINS_38420

MALV:

MALV_48580

MTY:	MTOK_04970

MPSC:

MARZ:

MGAD:

MHEV:

MSAR:

MANY:

MAUB:

MPOF:

MPHU:

MMUC:

MMAT:

MBOK:

MFG:	K6L26_09070

MSEI:

MFLV:

MCEE:

MMON:

MGO:	AFA91_14490

MHOL:

K3U96_06035

MSEN:

K3U95_21790

MPAE:

K0O64_06045

MRF:	MJO55_20980

MDF:	K0O62_22395

MCRO:

MGRO:

MAUS:

MFRE:

MBUG:

MYQ:	TUM20985_12530

MFLU:

HZU40_29210

MYH:	QU592_23600

MPAT:

MPNTM1_02624

MKR:	MKOR_40410

MPAK:

MIU77_04215

MJD:	JDM601_1056

MTER:

MMIN:

MHIB:

MHER:

MVM:	MJO54_06060

MKK:	MU0083_000994

SNF:	JYK04_07456(auaH_3)

LOB:	NEF87_000807

» show all

Reference

PMID:17630785

Authors

Yang X, Dubnau E, Smith I, Sampson NS

Title

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

Journal

Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x

Sequence

[mtu:Rv1106c]

Reference

PMID:21257778

Authors

Yang X, Gao J, Smith I, Dubnau E, Sampson NS

Title

Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.

Journal

J Bacteriol 193:1473-6 (2011)
DOI:10.1128/JB.01210-10

Sequence

[mtu:Rv1106c]

All links

Ontology (3)   
   GO (2)   
   COG (1)   
Gene (1)   
   OC (1)   
All databases (4)   

Download RDF

ENZYME: 1.1.1.145

Entry

EC 1.1.1.145                Enzyme

Name

3beta-hydroxy-Delta5-steroid dehydrogenase;
progesterone reductase;
Delta5-3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene steroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase;
3beta-hydroxy-5-ene-steroid oxidoreductase;
steroid-Delta5-3beta-ol dehydrogenase;
3beta-HSDH;
5-ene-3-beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene-steroid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase

Reaction(IUBMB)

a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid + NADH + H+ [RN:R03176]

Reaction(KEGG)

R03176;
(other) R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849 R09920

Substrate

3beta-hydroxy-Delta5-steroid [CPD:C03836];
NAD+ [CPD:C00003]

Product

3-oxo-Delta5-steroid [CPD:C01034];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced cosubstrate, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.

History

EC 1.1.1.145 created 1972

Pathway

ec00140

Steroid hormone biosynthesis

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K16045

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K26407

Poxviridae/Iridoviridae 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Genes

HSA:	3283(HSD3B1) 3284(HSD3B2)

PTR:	457165(HSD3B2) 469446

PPS:	100982464(HSD3B2) 100983009 100990187

GGO:	101141070 101141801 101146563(HSD3B2)

PON:	100451655 100452394 100455460

PPYG:

129015890 129015909 129015918

NLE:	100596087 100605995(HSD3B2) 100606563 100607955

HMH:	116469522 116469530(HSD3B2)

SSYN:

134733865 134733875 134734675(HSD3B1)

MCC:	712686(HSD3B2) 713091 713272 715337

MCF:	102129873 102133592 102134747 102135110(HSD3B2)

MTHB:

126931035 126931104 126931154 126951788

MNI:	105479071 105479074 105479078 105479082 105479084(HSD3B2)

CSAB:

103224104 103224109(HSD3B2)

CATY:

105599590 105599597(HSD3B2)

PANU:

100999145 101018740 101019096(HSD3B2)

TGE:	112624233 112634262(HSD3B2)

MLEU:

105541296(HSD3B2) 105541330

RRO:	104654599 104654602 104654605

RBB:	108528160 108528161 108528164

TFN:	117074250 117074256

PTEH:

111549589 111549591

CANG:

105505264 105505267

CJC:	100387484 100389654 100400416 100405879

SBQ:	101042680 101051416

CIMI:

108297130 108301104

ANAN:

105721680(HSD3B2) 105721706 110567017

CSYR:

103258418(HSD3B2)

MMUR:

105869786(HSD3B2)

LCAT:

123635118(HSD3B2)

PCOQ:

105809629(HSD3B2)

OGA:

100966795

MMU:	100043456(Hsd3b8) 100043461(Hsd3b9) 15492(Hsd3b1) 15493(Hsd3b2) 15494(Hsd3b3) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)

MCAL:

110288898 110290813 110290978 110291292 110291371 110291888

MPAH:

110315378 110319834 110319836 110320478 110320490

RNO:	24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)

MCOC:

116093252 116094199 116094200 116094201

ANU:	117707219 117707246 117707247 117707273 117707523

ASYL:

127682169 127682171 127682173 127682174 127682178

MUN:	110542496 110543775 110544885 110544899 110563733 110563735 132656956 132656957 132656958 132656961 132656962 132656967 132657118

CGE:	100770922 113830678 113833179 113833198

MAUA:

101837099 101842851(Hao2) 121138738 121142382

PROB:

127232674 127232675

PLEU:

114688199 114688619 114688620 114688621 114688750 114688751 114688752 114698547

MORG:

121437803 121437911 121438015 121438017

MFOT:

126490105 126510847

AAMP:

119801286 119801287 119801288 119801289

NGI:	103728305 103732007 103738837

HGL:	101707488(Hsd3b1) 101707858

CPOC:

100379573(Hsd3b1) 100725531 100725801

CCAN:

109702728 109702729

DORD:

105991916 105991917

DSP:	122118370 122118374

DMER:

138816599 138817117

PLOP:

125344738 125345248 125345249 125345254 125345257 125345259 125345261 125355478 125355479 125355483

NCAR:

124964015 124990189 124992819

MMMA:

107156205(Hao2) 107156207 107156209

ITI:	101959454 101959938 101960216

OCU:	100346986 100347914

OPI:	101522373 101522782

TUP:

102470981

GVR:	103584548 103607308

CFA:	483146(HSD3B2)

CLUD:

112664108

VVP:

112916789

VLG:

121490669

NPO:

129501295

AML:	100464280(HSD3B1)

UMR:

103677123

UAH:

113244362

UAR:

123795008

ELK:

111143436

LLV:

125099255

MPUF:

101680243

MNP:

132000700

MLK:

131809998

NVS:

122898812

ORO:

101378904

EJU:	114208061(HSD3B2)

ZCA:	113909475(HSD3B2)

MLX:	118000525(HSD3B2)

NSU:	110580487(HSD3B2)

LWW:

102742748

FCA:	100616070(HSD3B2)

PYU:

121027796

PCOO:

112872261

PBG:

122481024

PVIV:

125171536

LRUF:

124514119

LGF:

123598559

AJU:

106978496

PTG:

102957262

PPAD:

109272160

PUC:

125912196

PLEZ:

122228558

HHV:

120247640

BTA:	281824(HSD3B1)

BOM:

102274088

BIU:

109555859

BBUB:

102413429

BBIS:

104993819

CHX:	100860869(3BHSD)

OAS:	100190978(HSD3B1)

BTAX:

128045498

CSUM:

138073908

ODA:

120855999

CCAD:

122435367

MREE:

136146916

OVR:

110141729

MBEZ:

129541051

SSC:	445539(HSD3B1)

CFR:

102512447

CBAI:

105079257

CDK:

105089475

VPC:

102528409

BACU:

103015346

BMUS:

118884274

LVE:

103083046

OOR:

101284283

LALB:

132515997

GMF:

115859956

DDP:

132422304

DLE:

111179902

PCAD:

102987751

PSIU:

116758472

PPHC:

136125408

NASI:

112413050

ECB:	100034078(HSD3B2)

EPZ:	103548379(HSD3B2)

EAI:	106832920(HSD3B2)

MYB:	106723550(HSD3B2)

MMYO:

118672875(HSD3B2)

MLF:	106694328(HSD3B2)

MDT:	132220682(HSD3B2)

MYUM:

138996082(HSD3B2)

PKL:

118727130

EFUS:

103291359(HSD3B2)

MNA:	107545288(HSD3B2)

DRO:	112314004(HSD3B2)

SHON:

118981952(HSD3B2)

AJM:

119041699

PDIC:

114489256

PHAS:

123804497(HSD3B2)

MMF:

118637661

PPAM:

129063973

HAI:	109389868(HSD3B2)

RFQ:	117014453(HAO2)

PALE:

102891879

PGIG:

120585109

PVP:

105296358

RAY:	107518830(HSD3B2)

MJV:

108390800

TOD:

119236234

SARA:

101555226 101555490

SFUM:

130033045

SETR:

125997493

LAV:	100659049(HSD3B2)

TMU:

101358325

ETF:	101663671(HSD3B1)

DNM:

101447815

MDO:

100012668

GAS:

123247232

SHR:	100913530(HSD3B2)

AFZ:

127559197

PCW:	110219672(HSD3B2)

TVP:	118856490(HSD3B2)

PBRV:

138162150

OAA:

100080135

TACU:

119938651(HSD3B2)

GGA:	396015(HSD3B1)

PCOC:

116244326

MGP:

104915630

CJO:

107319373

TPAI:

128076148 128090414

LMUT:

125684639(HSD3B1)

NMEL:

110398845

APLA:

101803865(HSD3B1)

ACYG:

106045741(HSD3B1)

CATA:

118259816(HSD3B1)

AFUL:

116502173

TGU:	751770(HSD3B1)

LSR:

110480744

SCAN:

103827136

PMOA:

120506495

OTC:

121339296

PRUF:

121351666

ATRC:

139592866

GFR:

102039409

FAB:

101817697

OMA:

130265090

PHI:

102101526

PMAJ:

107211459

CCAE:

111938581

CCW:

104687106

CBRC:

103613933

ACOE:

138112257

ETL:

114058198

ZAB:

102062520

ZLE:

135452668

ACHL:

103801073

SVG:

106857875

MMEA:

130582277

HRT:

120749079

SATI:

136375583

CCIC:

134056406

FPG:

101921564

FCH:

102052697

CCRI:

104162430

NNT:

104410259

SHAB:

115601668

ACUN:

113485872

TALA:

104357901

ACHC:

115344139

HALD:

104319887

HLE:

104831735

AGEN:

126049087

HHAR:

128144955(HSD3B1)

GCL:

127029573

CSTI:

104558363

LDI:

104351289

MNB:

103779544

DPUB:

104298412

PPUS:

135175188

AVIT:

104277939

BRHI:

104496619

EGZ:

104126518

NNI:

104008615

PCRI:

104035039

PCAO:

104053168

PADL:

103921223

AFOR:

103905431

FGA:

104079993

GSTE:

104255879

CBOY:

140646711

CLV:

102087460

CNIC:

136002658

MUI:

104539044

PGUU:

104468993

PLET:

104617853

EHS:

104512760

CMAC:

104476511

CUCA:

104055667

TEO:

104373662

BREG:

104641481

OHA:

104327359

ACAR:

104520429

CPEA:

104384975

CVF:

104293163

RTD:

128904122

CRID:

134523865

AAM:

106497227

AROW:

112963963

NPD:

112960083

TGT:

104576502

DNE:

112985919

SCAM:

104150689

ASN:	102367786(HSD3B1)

AMJ:	109280168(HSD3B1)

CPOO:

109319128(HSD3B1)

GGN:	109304596(HSD3B1)

PSS:

102453952

CMY:

102934871

CCAY:

125622274

DCC:

119843575

CPIC:

101946936

TST:

117886232

CABI:

116817817

MRV:

120396043

ACS:	100561899(hsd3b1)

ASAO:

132766487(HSD3B1)

PVT:

110076926

SUND:

121922906

PBI:

103067418

PMUR:

107285816

CTIG:

120306125

TSR:

106542700

PGUT:

117661842

PCAE:

139311012

APRI:

131193284(HSD3B1)

PTEX:

113444507

NSS:

113417241

VKO:

123033249

PMUA:

114587929(HSD3B2)

PRAF:

128404595(HSD3B2)

ZVI:	118075222(HSD3B2)

HCG:

128345684

GJA:

107114856

STOW:

125425234(HSD3B2)

EMC:

129345698

XLA:	734818(hsd3b1.L)

XTR:

100490622

NPR:

108802532

RTEM:

120928726

ACAT:

141129472(HSD3B1)

BBUF:

120994332

DTC:

141091417

PWL:	138248956(HSD3B1)

MUO:	115471398(HSD3B1)

GSH:	117358938(HSD3B1)

DRE:	373131(hsd3b2) 553532(hsd3b1)

SRX:

107712267

SANH:

107658243

SGH:

107569293

CCAR:

109048590 109052439(hsd3b1)

CAUA:

113108554 113108799

CGIB:

127965123 128019700

PTET:

122351771(hsd3b1)

LROH:

127170525(hsd3b1)

GRF:	141340889(hsd3b1)

OMC:	131546787(hsd3b1)

PPRM:

120466714(hsd3b1)

RKG:	130076948(hsd3b1)

MAMB:

125270537(hsd3b1)

CIDE:

127518655

CERY:

137035985(hsd3b1)

MASI:

127448584

TROS:

130555852(hsd3b1)

TDW:	130427658(hsd3b1)

MANU:

129451507(hsd3b1)

PDAB:

135730984(hsd3b1)

IPU:	100304475(hsd3b1)

IFU:	128609137(hsd3b1)

PHYP:

113524942(hsd3b1)

SMEO:

124379336(hsd3b1)

TFD:	113654422(hsd3b1)

TVC:	132850628(hsd3b1)

CGAR:

128524370(hsd3b1)

NGRA:

132891244(hsd3b1)

TRN:	134323829(hsd3b1)

AMEX:

103027852(hsd3b1)

CMAO:

118800102(hsd3b1)

EEE:

113587753

CHAR:

105913236 105913280 105913281

SPIL:

134078497(hsd3b1) 134095873

TRU:	101069884(hsd3b1)

TFS:	130530194(hsd3b1)

TNG:	GSTEN00029150G001

LCO:	104921488(hsd3b1)

TBEN:

117495881(hsd3b1)

CGOB:

115026845(hsd3b1)

PGEO:

117466261(hsd3b1)

GACU:

117536557(hsd3b1)

EMAC:

134867270(hsd3b1)

ELY:	117251590(hsd3b1)

EFO:	125900207(hsd3b1)

PLEP:

121949401(hsd3b1) 121963657

SLUC:

116059361(hsd3b1)

ECRA:

117953315(hsd3b1)

ESP:

116697664

PFLV:

114564020

GAT:	120833929(hsd3b1)

PPUG:

119228951(hsd3b1)

AFB:	129104536(hsd3b1)

CLUM:

117750405(hsd3b1)

PSWI:

130204482(hsd3b1)

CANA:

137782894(hsd3b1)

CVE:	137890194(hsd3b1)

MSAM:

119884914 119904488(hsd3b1)

SCHU:

122885279(hsd3b1)

CUD:	121523133(hsd3b1)

SPUL:

138592290(hsd3b1)

LMIX:

132986866(hsd3b1)

ALAT:

119025245(hsd3b1)

ASTR:

137605353(hsd3b1)

MZE:

101485719

ONL:	100534568(hsd3b1)

OAU:	116332553(hsd3b1)

OLA:	100144358(3bhsd)

OML:	112138010(hsd3b1)

CSAI:

133446387(hsd3b1)

XMA:

102228303

XCO:

114147930

XHE:

116723048

PRET:

103477979

PFOR:

103152152

PLAI:

106939754

PMEI:

106917521

GAF:	122839771(hsd3b1)

PPRL:

129360909(hsd3b1)

CVG:

107087352

CTUL:

119774713(hsd3b1)

GMU:	124871021(hsd3b1)

NFU:	107389612(hsd3b1)

KMR:	108244192(hsd3b1)

ALIM:

106531920

NWH:	119419363(hsd3b1)

AOCE:

111570570(hsd3b1)

EJA:	138200781(hsd3b1)

BFRE:

138629583(hsd3b1)

MCEP:

125017257(hsd3b1)

CSEM:

103391994(hsd3b1)

POV:

109637945

SSEN:

122785783(hsd3b1)

SSOE:

131475547(hsd3b1)

HHIP:

117755029 117755030

HSP:	118119640 118120310

PPLT:

128455946(hsd3b1)

SMAU:

118283187(hsd3b1)

LCF:

108902437

SDU:

111218347

SLAL:

111652102

XGL:	120801969(hsd3b1)

HCQ:

109522071

SSCV:

125973254(hsd3b1)

SBIA:

133511988(hsd3b1)

PEE:	133410274(hsd3b1)

PTAO:

133486409(hsd3b1)

BPEC:

110156192(hsd3b1)

ENY:	140359840(hsd3b1)

MALB:

109951646

BSPL:

114847637(hsd3b1)

SJO:	128367682(hsd3b1)

SSCO:

133993012(hsd3b1)

GMH:

115533088

SASA:

106586600

STRU:

115161098

OTW:	112240651(hsd3b1)

OMY:	100136743(hsd3b1)

OGO:	124044100(hsd3b1)

ONE:

115112196

OKI:

109869285

OKE:	118371546(hsd3b1)

OMM:	135519168(hsd3b1)

OCLA:

139403614

SALP:

111978723

SNH:	120058421(hsd3b1)

CCLU:

121536290(hsd3b1)

ELS:

105016430

OEP:	134017697(hsd3b1)

SFM:

108937872

PKI:

111860692

AANG:

118214002 118214003

AROT:

135241156 135241158

CCOG:

133116268(hsd3b1)

LOC:	102685561(hsd3b1)

PSPA:

121320746(hsd3b1)

ARUT:

117406697 117406856

PSEX:

120522925(hsd3b1)

LCM:

102345588

CMK:	103180179(hsd3b1) 121852133

RTP:	109918392(hsd3b1)

HOC:	132820585(hsd3b1)

LERI:

129702520(hsd3b1)

HAKA:

140727706(hsd3b1)

PMRN:

116954501

LRJ:

133347820

BFO:	118415735 118426116

BBEL:

109470289 109481615

LPIC:

129254859

AJJ:	139968024 139968025 139968026 139968030

AFIL:

140138346 140138347 140168992 140169339 140169916 140170474 140170475

PFLL:

139119426 139150811

DME:	Dmel_CG7724(CG7724)

DER:

6543694

DSI:	Dsimw501_GD14693(Dsim_GD14693)

DYA:	Dyak_GE19901

DSR:	110187899 110190103

DPO:

4813984

DPE:

6603899

DMN:

108165559

DWI:

6645028

DGR:

6558385

DMO:	Dmoj_GI12485

DAZ:

108612818

DNV:

108651018

DHE:

111602930

CCAT:

101455915

BOD:

106619208

BDR:

105225278

RZE:

108370312

AOQ:

129240938

ALUD:

128859875

TDA:

119666775

MDE:

101899660

SCAC:

106092781

LCQ:

111691019

LSQ:

119600382

CVJ:	135963146 135963147

GFS:

119645278

ECOE:

129948506

CLON:

129611542

HIS:

119650207

AGA:

1277239

ACOZ:

120951979

AARA:

120897593

AMER:

121593679

ASTE:

118514455

AMAP:

126563092

AFUN:

125767669

AMOU:

128302512

AMRS:

128712767

AALI:

118465094

ACOS:

131264985

AAG:

5566270

AALB:

109407756 109418935

ASUA:

134214407

CQU:	CpipJ_CPIJ003056

CPII:

120432614

CBRI:

134829891

CNS:

116347823

BCOO:

119081235

LLL:

129792651

PPAP:

129801789

NVI:

100120136

CSOL:

105366624

TPRE:

106650065

FAS:

105264423

DAM:

107039335

VCAN:

122411680

CCIN:

107268819

NPT:

124218962

NFB:

124182898

NLO:

107222152

NVG:

124305414

AROA:

105683351

DCI:

103516518

CLEC:

106661338

NLU:

111044911

HVI:

124367113

MQU:

128995074

FOC:

113210108

TPAL:

117644725

ZNE:

110831195

CSEC:

111870363

PAME:

138715168

IEL:

124167557

HAMR:

139690170

FCD:

110862702

DMK:

116926030

DPZ:

124315410

PVM:

113815316

PJA:

122252315

PCHN:

125025755

PMOO:

119576789

HAME:

121875688

PCLA:

123764960

CQD:

128692025

PTRU:

123519041

ESN:

126998836

MNZ:

135202439

MRJ:

136847317

ISC:

8053025

DSV:

119445622

RSAN:

119377584 119390488

RMP:

119169799

VDE:	111247588 111254724

VJA:	111264476 111268118

GOE:	100898467 100905877

TUT:

107363285

DPTE:

113794090

DFR:

124490209

CSCU:

111622487

CVS:

136985026

PTEP:

107437550

ABRU:

129960448

UDV:

129219275

SDM:

118201694

LPOL:

106475760

PMEO:

129587684

HRO:	HELRODRAFT_89375

PVUL:

126824716

LSAX:

138976104

GAE:

121389292

HRF:	124140223 124140224 124140226 124141700

HRJ:	124260823 124260824 124278058

HASI:

137256388 137284947 137293342

HCRA:

139455224 139472337 139472362 139472363 139472401

CRG:	105321517 105332656

CANU:

128186867 128188117 128188594

CVN:	111136775 111137023 111137166

OED:	125654276 125659193 125659727

MYI:

110457155

PMAX:

117333059 117333060 117333062 117333069

AIRR:

138331179 138331399 138331633

MMER:

123525098 123534278 123534660 123535125 123535257 123535266 123552007

RPHI:

132742228 132742229 132743368 132753356 132759419 132759420

DPOL:

127839711 127856352 127861538

MAEA:

128229618 128232487 128232575

OSN:

115219210

LJP:	135468058 135477165

LAK:

106151343

LLON:

135485103 135502377

ENW:	MJO57_19210

EMP:	EZMO1_1200(nsdHL)

PWU:	A8O14_06055

MTU:

Rv1106c

MTV:	RVBD_1106c

MTC:

MT1137

MRA:

MRA_1117

MTF:	TBFG_11128

MTB:	TBMG_02877

MTK:	TBSG_02893

MTZ:	TBXG_002857

MTG:	MRGA327_06925

MTI:	MRGA423_06915

MTE:	CCDC5079_1022

MTUR:

CFBS_1174

MTL:	CCDC5180_1014

MTO:	MTCTRI2_1136

MTD:

UDA_1106c

MTN:	ERDMAN_1239

MTJ:	J112_05975

MTUB:

MT7199_1133

MTUC:

J113_07785

MTUE:

J114_05980

MTX:	M943_05820

MTUH:

I917_07855

MTUL:

TBHG_01091

MTUT:

HKBT1_1172

MTUU:

HKBT2_1178

MTQ:	HKBS1_1174

MBO:	BQ2027_MB1136C

MBB:

BCG_1166c

MBT:

JTY_1139

MBM:	BCGMEX_1138c

MBK:	K60_011910

MBX:

BCGT_0934

MAF:

MAF_11210

MMIC:

RN08_1242

MCE:	MCAN_11161

MCQ:	BN44_11231

MCV:	BN43_30163

MCX:	BN42_20954

MCZ:	BN45_30150

MORY:

MO_001188

MLE:

ML1942

MLB:

MLBr01942

MPA:

MAP_2688

MAO:

MAP4_1128

MAVI:

RC58_05605

MAVU:

RE97_05600

MAV:

MAV_1225

MAVM:

MAA44156_03036

MIT:

OCO_11340

MIA:

OCU_11320

MID:

MIP_01824

MYO:

OEM_11450

MCHI:

AN480_06750

MIR:

OCQ_11350

MMAL:

CKJ54_05520

MLP:

MLM_1173

MMAN:

MMAN_54580

MSER:

MTY59_30480

MSA:	Mycsm_05045

MUL:

MUL_0172

MMI:

MMAR_4359

MMAE:

MMARE11_41790

MLI:	MULP_04570

MPSE:

MPSD_44990

MSHO:

MSHO_16920

MMC:

Mmcs_4109

MKM:

Mkms_4185

MJL:

Mjls_4340

MMM:

W7S_05545

MKN:	MKAN_07985

MYV:	G155_22700

MYE:	AB431_06460

MHAD:

B586_07090

MDX:	BTO20_08365

MSHG:

MSG_03923

MFJ:	MFLOJ_47450

MSTO:

MSTO_51430

MSIM:

MSIM_37390

MSAK:

MSAS_22240

MKU:	I2456_20620

MLW:	MJO58_21440

MXE:	MYXE_14010

MNV:	MNVI_06140

MPAG:

C0J29_23965

MNM:	MNVM_07790

MGOR:

H0P51_22240

MCOO:

MCOO_20360

MBAI:

MB901379_03818

MSEO:

MSEO_27010

MHEK:

JMUB5695_01344

MGAU:

MGALJ_31210

MLJ:	MLAC_06830

MBRD:

MBRA_27460

MSHJ:

MSHI_03080

MMAM:

K3U93_19010

MSPG:

F6B93_17425

MOT:	LTS72_03400

MLM:	MLPF_2463(hsd)

MPAA:

MKK62_05735

MKY:	IWGMT90018_50180

MADI:

A7U43_09340

MWU:	PT015_11765

MYW:	BVC93_17935

MYJ:	BCA37_24750

MSM:	MSMEG_5228

MSG:	MSMEI_5091

MSB:	LJ00_25860

MSN:	LI99_25865

MSH:	LI98_25870

MVA:

Mvan_4635

MGI:

Mflv_2075

MSP:	Mspyr1_14990

MCB:	Mycch_4050

MNE:	D174_21420

MYN:	MyAD_21005

MFT:	XA26_46570

MPHL:

MPHLCCUG_04229

MVQ:

MYVA_4444

MLL:	B1R94_06430

MRH:	MycrhN_3550

MTHN:

4412656_03537

MHAS:

MHAS_03213

MDU:	MDUV_00690

MCHT:

MCHIJ_25440

MAUU:

NCTC10437_04362

MMAG:

MMAD_42700

MMOR:

MMOR_18320

MFX:	MFAL_37920

MAIC:

MAIC_43720

MIJ:	MINS_38420

MALV:

MALV_48580

MTY:	MTOK_04970

MPSC:

MPSYJ_22130

MARZ:

MARA_54320

MGAD:

MGAD_52480

MHEV:

MHEL_09990

MSAR:

MSAR_27010

MANY:

MANY_26880

MAUB:

MAUB_43590

MPOF:

MPOR_47010

MPHU:

MPHO_25810

MMUC:

C1S78_005420

MMAT:

MMAGJ_05590

MBOK:

MBOE_27320

MFG:	K6L26_09070

MSEI:

MSEDJ_54960

MFLV:

NCTC10271_01108

MCEE:

MCEL_44150

MMON:

EWR22_22255

MGO:	AFA91_14490

MHOL:

K3U96_06035

MSEN:

K3U95_21790

MPAE:

K0O64_06045

MRF:	MJO55_20980

MDF:	K0O62_22395

MCRO:

MI149_06755

MGRO:

FZ046_26400

MAUS:

JN090_22515

MFRE:

EXE63_22420

MBUG:

MU0053_001026

MYQ:	TUM20985_12530

MFLU:

HZU40_29210

MYH:	QU592_23600

MPAT:

MPNTM1_02624

MKR:	MKOR_40410

MPAK:

MIU77_04215

MJD:	JDM601_1056

MTER:

4434518_01040

MMIN:

MMIN_27080

MHIB:

MHIB_06150

MHER:

K3U94_05970

MVM:	MJO54_06060

MKK:	MU0083_000994

SNF:	JYK04_07456(auaH_3)

LOB:	NEF87_000807

» show all

Reference

1 [PMID:4226148]

Authors

Cheatum SG, Watten JC.

Title

Purification and properties of 3-beta-hydroxysteroid dehydrogenase and delta-5-3-ketosteroid isomerase from bovine corpora lutea.

Journal

Biochim Biophys Acta 122:1-13 (1966)
DOI:10.1016/0926-6593(66)90086-5

Reference

2 [PMID:14220672]

Authors

KORITZ SB.

Title

THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY SMALL PARTICLES FROM RAT ADRENAL.

Journal

Biochemistry 3:1098-102 (1964)
DOI:10.1021/bi00896a015

Reference

Authors

Neville AM, Orr JC, Engel LL.

Title

Delta5-3beta-Hydroxy steroid dehydrogenase activities of bovine adrenal cortex.

Journal

Biochem J 107:20 (1968)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.145

IUBMB Enzyme Nomenclature:

1.1.1.145

ExPASy - ENZYME nomenclature database:

1.1.1.145

BRENDA, the Enzyme Database:

1.1.1.145

CAS:

9044-85-3

All links

Gene (89)   
   MGENES (62)   
   RefGene (27)   
Protein sequence (392)   
   UniProt (321)   
   SWISS-PROT (25)   
   RefSeq(pep) (33)   
   PDBSTR (4)   
   PMD (9)   
DNA sequence (166)   
   RefSeq(nuc) (44)   
   GenBank (65)   
   EMBL (57)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   InterPro (4)   
All databases (655)   

Download RDF

ENZYME: 5.3.3.1

Entry

EC 5.3.3.1                  Enzyme

Name

steroid Delta-isomerase;
hydroxysteroid isomerase;
steroid isomerase;
Delta5-ketosteroid isomerase;
Delta5(or Delta4)-3-keto steroid isomerase;
Delta5-steroid isomerase;
3-oxosteroid isomerase;
Delta5-3-keto steroid isomerase;
Delta5-3-oxosteroid isomerase

Class

Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds

Sysname

3-oxosteroid Delta5-Delta4-isomerase

Reaction(IUBMB)

a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]

Reaction(KEGG)

R02644 > R09955;
(other) R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849 R09920

Substrate

3-oxo-Delta5-steroid [CPD:C01034]

Product

3-oxo-Delta4-steroid [CPD:C00619]

Comment

This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).

History

EC 5.3.3.1 created 1961

Pathway

ec00140

Steroid hormone biosynthesis

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K01822

steroid Delta-isomerase

K16045

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

K26407

Poxviridae/Iridoviridae 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Genes

HSA:	3283(HSD3B1) 3284(HSD3B2)

PTR:	457165(HSD3B2) 469446

PPS:	100982464(HSD3B2) 100983009 100990187

GGO:	101141070 101141801 101146563(HSD3B2)

PON:	100451655 100452394 100455460

PPYG:

129015890 129015909 129015918

NLE:	100596087 100605995(HSD3B2) 100606563 100607955

HMH:	116469522 116469530(HSD3B2)

SSYN:

134733865 134733875 134734675(HSD3B1)

MCC:	712686(HSD3B2) 713091 713272 715337

MCF:	102129873 102133592 102134747 102135110(HSD3B2)

MTHB:

126931035 126931104 126931154 126951788

MNI:	105479071 105479074 105479078 105479082 105479084(HSD3B2)

CSAB:

103224104 103224109(HSD3B2)

CATY:

105599590 105599597(HSD3B2)

PANU:

100999145 101018740 101019096(HSD3B2)

TGE:	112624233 112634262(HSD3B2)

MLEU:

105541296(HSD3B2) 105541330

RRO:	104654599 104654602 104654605

RBB:	108528160 108528161 108528164

TFN:	117074250 117074256

PTEH:

111549589 111549591

CANG:

105505264 105505267

CJC:	100387484 100389654 100400416 100405879

SBQ:	101042680 101051416

CIMI:

108297130 108301104

ANAN:

105721680(HSD3B2) 105721706 110567017

CSYR:

103258418(HSD3B2)

MMUR:

105869786(HSD3B2)

LCAT:

123635118(HSD3B2)

PCOQ:

105809629(HSD3B2)

OGA:

100966795

MMU:	100043456(Hsd3b8) 100043461(Hsd3b9) 15492(Hsd3b1) 15493(Hsd3b2) 15494(Hsd3b3) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)

MCAL:

110288898 110290813 110290978 110291292 110291371 110291888

MPAH:

110315378 110319834 110319836 110320478 110320490

RNO:	24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)

MCOC:

116093252 116094199 116094200 116094201

ANU:	117707219 117707246 117707247 117707273 117707523

ASYL:

127682169 127682171 127682173 127682174 127682178

MUN:	110542496 110543775 110544885 110544899 110563733 110563735 132656956 132656957 132656958 132656961 132656962 132656967 132657118

CGE:	100770922 113830678 113833179 113833198

MAUA:

101837099 101842851(Hao2) 121138738 121142382

PROB:

127232674 127232675

PLEU:

114688199 114688619 114688620 114688621 114688750 114688751 114688752 114698547

MORG:

121437803 121437911 121438015 121438017

MFOT:

126490105 126510847

AAMP:

119801286 119801287 119801288 119801289

NGI:	103728305 103732007 103738837

HGL:	101707488(Hsd3b1) 101707858

CPOC:

100379573(Hsd3b1) 100725531 100725801

CCAN:

109702728 109702729

DORD:

105991916 105991917

DSP:	122118370 122118374

DMER:

138816599 138817117

PLOP:

125344738 125345248 125345249 125345254 125345257 125345259 125345261 125355478 125355479 125355483

NCAR:

124964015 124990189 124992819

MMMA:

107156205(Hao2) 107156207 107156209

ITI:	101959454 101959938 101960216

OCU:	100346986 100347914

OPI:	101522373 101522782

TUP:

102470981

GVR:	103584548 103607308

CFA:	483146(HSD3B2)

CLUD:

112664108

VVP:

112916789

VLG:

121490669

NPO:

129501295

AML:	100464280(HSD3B1)

UMR:

103677123

UAH:

113244362

UAR:

123795008

ELK:

111143436

LLV:

125099255

MPUF:

101680243

MNP:

132000700

MLK:

131809998

NVS:

122898812

ORO:

101378904

EJU:	114208061(HSD3B2)

ZCA:	113909475(HSD3B2)

MLX:	118000525(HSD3B2)

NSU:	110580487(HSD3B2)

LWW:

102742748

FCA:	100616070(HSD3B2)

PYU:

121027796

PCOO:

112872261

PBG:

122481024

PVIV:

125171536

LRUF:

124514119

LGF:

123598559

AJU:

106978496

PTG:

102957262

PPAD:

109272160

PUC:

125912196

PLEZ:

122228558

HHV:

120247640

BTA:	281824(HSD3B1)

BOM:

102274088

BIU:

109555859

BBUB:

102413429

BBIS:

104993819

CHX:	100860869(3BHSD)

OAS:	100190978(HSD3B1)

BTAX:

128045498

CSUM:

138073908

ODA:

120855999

CCAD:

122435367

MREE:

136146916

OVR:

110141729

MBEZ:

129541051

SSC:	445539(HSD3B1)

CFR:

102512447

CBAI:

105079257

CDK:

105089475

VPC:

102528409

BACU:

103015346

BMUS:

118884274

LVE:

103083046

OOR:

101284283

LALB:

132515997

GMF:

115859956

DDP:

132422304

DLE:

111179902

PCAD:

102987751

PSIU:

116758472

PPHC:

136125408

NASI:

112413050

ECB:	100034078(HSD3B2)

EPZ:	103548379(HSD3B2)

EAI:	106832920(HSD3B2)

MYB:	106723550(HSD3B2)

MMYO:

118672875(HSD3B2)

MLF:	106694328(HSD3B2)

MDT:	132220682(HSD3B2)

MYUM:

138996082(HSD3B2)

PKL:

118727130

EFUS:

103291359(HSD3B2)

MNA:	107545288(HSD3B2)

DRO:	112314004(HSD3B2)

SHON:

118981952(HSD3B2)

AJM:

119041699

PDIC:

114489256

PHAS:

123804497(HSD3B2)

MMF:

118637661

PPAM:

129063973

HAI:	109389868(HSD3B2)

RFQ:	117014453(HAO2)

PALE:

102891879

PGIG:

120585109

PVP:

105296358

RAY:	107518830(HSD3B2)

MJV:

108390800

TOD:

119236234

SARA:

101555226 101555490

SFUM:

130033045

SETR:

125997493

LAV:	100659049(HSD3B2)

TMU:

101358325

ETF:	101663671(HSD3B1)

DNM:

101447815

MDO:

100012668

GAS:

123247232

SHR:	100913530(HSD3B2)

AFZ:

127559197

PCW:	110219672(HSD3B2)

TVP:	118856490(HSD3B2)

PBRV:

138162150

OAA:

100080135

TACU:

119938651(HSD3B2)

GGA:	396015(HSD3B1)

PCOC:

116244326

MGP:

104915630

CJO:

107319373

TPAI:

128076148 128090414

LMUT:

125684639(HSD3B1)

NMEL:

110398845

APLA:

101803865(HSD3B1)

ACYG:

106045741(HSD3B1)

CATA:

118259816(HSD3B1)

AFUL:

116502173

TGU:	751770(HSD3B1)

LSR:

110480744

SCAN:

103827136

PMOA:

120506495

OTC:

121339296

PRUF:

121351666

ATRC:

139592866

GFR:

102039409

FAB:

101817697

OMA:

130265090

PHI:

102101526

PMAJ:

107211459

CCAE:

111938581

CCW:

104687106

CBRC:

103613933

ACOE:

138112257

ETL:

114058198

ZAB:

102062520

ZLE:

135452668

ACHL:

103801073

SVG:

106857875

MMEA:

130582277

HRT:

120749079

SATI:

136375583

CCIC:

134056406

FPG:

101921564

FCH:

102052697

CCRI:

104162430

NNT:

104410259

SHAB:

115601668

ACUN:

113485872

TALA:

104357901

ACHC:

115344139

HALD:

104319887

HLE:

104831735

AGEN:

126049087

HHAR:

128144955(HSD3B1)

GCL:

127029573

CSTI:

104558363

LDI:

104351289

MNB:

103779544

DPUB:

104298412

PPUS:

135175188

AVIT:

104277939

BRHI:

104496619

EGZ:

104126518

NNI:

104008615

PCRI:

104035039

PCAO:

104053168

PADL:

103921223

AFOR:

103905431

FGA:

104079993

GSTE:

104255879

CBOY:

140646711

CLV:

102087460

CNIC:

136002658

MUI:

104539044

PGUU:

104468993

PLET:

104617853

EHS:

104512760

CMAC:

104476511

CUCA:

104055667

TEO:

104373662

BREG:

104641481

OHA:

104327359

ACAR:

104520429

CPEA:

104384975

CVF:

104293163

RTD:

128904122

CRID:

134523865

AAM:

106497227

AROW:

112963963

NPD:

112960083

TGT:

104576502

DNE:

112985919

SCAM:

104150689

ASN:	102367786(HSD3B1)

AMJ:	109280168(HSD3B1)

CPOO:

109319128(HSD3B1)

GGN:	109304596(HSD3B1)

PSS:

102453952

CMY:

102934871

CCAY:

125622274

DCC:

119843575

CPIC:

101946936

TST:

117886232

CABI:

116817817

MRV:

120396043

ACS:	100561899(hsd3b1)

ASAO:

132766487(HSD3B1)

PVT:

110076926

SUND:

121922906

PBI:

103067418

PMUR:

107285816

CTIG:

120306125

TSR:

106542700

PGUT:

117661842

PCAE:

139311012

APRI:

131193284(HSD3B1)

PTEX:

113444507

NSS:

113417241

VKO:

123033249

PMUA:

114587929(HSD3B2)

PRAF:

128404595(HSD3B2)

ZVI:	118075222(HSD3B2)

HCG:

128345684

GJA:

107114856

STOW:

125425234(HSD3B2)

EMC:

129345698

XLA:	734818(hsd3b1.L)

XTR:

100490622

NPR:

108802532

RTEM:

120928726

ACAT:

141129472(HSD3B1)

BBUF:

120994332

DTC:

141091417

PWL:	138248956(HSD3B1)

MUO:	115471398(HSD3B1)

GSH:	117358938(HSD3B1)

DRE:	373131(hsd3b2) 553532(hsd3b1)

SRX:

107712267

SANH:

107658243

SGH:

107569293

CCAR:

109048590 109052439(hsd3b1)

CAUA:

113108554 113108799

CGIB:

127965123 128019700

PTET:

122351771(hsd3b1)

LROH:

127170525(hsd3b1)

GRF:	141340889(hsd3b1)

OMC:	131546787(hsd3b1)

PPRM:

120466714(hsd3b1)

RKG:	130076948(hsd3b1)

MAMB:

125270537(hsd3b1)

CIDE:

127518655

CERY:

137035985(hsd3b1)

MASI:

127448584

TROS:

130555852(hsd3b1)

TDW:	130427658(hsd3b1)

MANU:

129451507(hsd3b1)

PDAB:

135730984(hsd3b1)

IPU:	100304475(hsd3b1)

IFU:	128609137(hsd3b1)

PHYP:

113524942(hsd3b1)

SMEO:

124379336(hsd3b1)

TFD:	113654422(hsd3b1)

TVC:	132850628(hsd3b1)

CGAR:

128524370(hsd3b1)

NGRA:

132891244(hsd3b1)

TRN:	134323829(hsd3b1)

AMEX:

103027852(hsd3b1)

CMAO:

118800102(hsd3b1)

EEE:

113587753

CHAR:

105913236 105913280 105913281

SPIL:

134078497(hsd3b1) 134095873

TRU:	101069884(hsd3b1)

TFS:	130530194(hsd3b1)

TNG:	GSTEN00029150G001

LCO:	104921488(hsd3b1)

TBEN:

117495881(hsd3b1)

CGOB:

115026845(hsd3b1)

PGEO:

117466261(hsd3b1)

GACU:

117536557(hsd3b1)

EMAC:

134867270(hsd3b1)

ELY:	117251590(hsd3b1)

EFO:	125900207(hsd3b1)

PLEP:

121949401(hsd3b1) 121963657

SLUC:

116059361(hsd3b1)

ECRA:

117953315(hsd3b1)

ESP:

116697664

PFLV:

114564020

GAT:	120833929(hsd3b1)

PPUG:

119228951(hsd3b1)

AFB:	129104536(hsd3b1)

CLUM:

117750405(hsd3b1)

PSWI:

130204482(hsd3b1)

CANA:

137782894(hsd3b1)

CVE:	137890194(hsd3b1)

MSAM:

119884914 119904488(hsd3b1)

SCHU:

122885279(hsd3b1)

CUD:	121523133(hsd3b1)

SPUL:

138592290(hsd3b1)

LMIX:

132986866(hsd3b1)

ALAT:

119025245(hsd3b1)

ASTR:

137605353(hsd3b1)

MZE:

101485719

ONL:	100534568(hsd3b1)

OAU:	116332553(hsd3b1)

OLA:	100144358(3bhsd)

OML:	112138010(hsd3b1)

CSAI:

133446387(hsd3b1)

XMA:

102228303

XCO:

114147930

XHE:

116723048

PRET:

103477979

PFOR:

103152152

PLAI:

106939754

PMEI:

106917521

GAF:	122839771(hsd3b1)

PPRL:

129360909(hsd3b1)

CVG:

107087352

CTUL:

119774713(hsd3b1)

GMU:	124871021(hsd3b1)

NFU:	107389612(hsd3b1)

KMR:	108244192(hsd3b1)

ALIM:

106531920

NWH:	119419363(hsd3b1)

AOCE:

111570570(hsd3b1)

EJA:	138200781(hsd3b1)

BFRE:

138629583(hsd3b1)

MCEP:

125017257(hsd3b1)

CSEM:

103391994(hsd3b1)

POV:

109637945

SSEN:

122785783(hsd3b1)

SSOE:

131475547(hsd3b1)

HHIP:

117755029 117755030

HSP:	118119640 118120310

PPLT:

128455946(hsd3b1)

SMAU:

118283187(hsd3b1)

LCF:

108902437

SDU:

111218347

SLAL:

111652102

XGL:	120801969(hsd3b1)

HCQ:

109522071

SSCV:

125973254(hsd3b1)

SBIA:

133511988(hsd3b1)

PEE:	133410274(hsd3b1)

PTAO:

133486409(hsd3b1)

BPEC:

110156192(hsd3b1)

ENY:	140359840(hsd3b1)

MALB:

109951646

BSPL:

114847637(hsd3b1)

SJO:	128367682(hsd3b1)

SSCO:

133993012(hsd3b1)

GMH:

115533088

SASA:

106586600

STRU:

115161098

OTW:	112240651(hsd3b1)

OMY:	100136743(hsd3b1)

OGO:	124044100(hsd3b1)

ONE:

115112196

OKI:

109869285

OKE:	118371546(hsd3b1)

OMM:	135519168(hsd3b1)

OCLA:

139403614

SALP:

111978723

SNH:	120058421(hsd3b1)

CCLU:

121536290(hsd3b1)

ELS:

105016430

OEP:	134017697(hsd3b1)

SFM:

108937872

PKI:

111860692

AANG:

118214002 118214003

AROT:

135241156 135241158

CCOG:

133116268(hsd3b1)

LOC:	102685561(hsd3b1)

PSPA:

121320746(hsd3b1)

ARUT:

117406697 117406856

PSEX:

120522925(hsd3b1)

LCM:

102345588

CMK:	103180179(hsd3b1) 121852133

RTP:	109918392(hsd3b1)

HOC:	132820585(hsd3b1)

LERI:

129702520(hsd3b1)

HAKA:

140727706(hsd3b1)

PMRN:

116954501

LRJ:

133347820

BFO:	118415735 118426116

BBEL:

109470289 109481615

LPIC:

129254859

AJJ:	139968024 139968025 139968026 139968030

AFIL:

140138346 140138347 140168992 140169339 140169916 140170474 140170475

PFLL:

139119426 139150811

DME:	Dmel_CG7724(CG7724)

DER:

6543694

DSI:	Dsimw501_GD14693(Dsim_GD14693)

DYA:	Dyak_GE19901

DSR:	110187899 110190103

DPO:

4813984

DPE:

6603899

DMN:

108165559

DWI:

6645028

DGR:

6558385

DMO:	Dmoj_GI12485

DAZ:

108612818

DNV:

108651018

DHE:

111602930

CCAT:

101455915

BOD:

106619208

BDR:

105225278

RZE:

108370312

AOQ:

129240938

ALUD:

128859875

TDA:

119666775

MDE:

101899660

SCAC:

106092781

LCQ:

111691019

LSQ:

119600382

CVJ:	135963146 135963147

GFS:

119645278

ECOE:

129948506

CLON:

129611542

HIS:

119650207

AGA:

1277239

ACOZ:

120951979

AARA:

120897593

AMER:

121593679

ASTE:

118514455

AMAP:

126563092

AFUN:

125767669

AMOU:

128302512

AMRS:

128712767

AALI:

118465094

ACOS:

131264985

AAG:

5566270

AALB:

109407756 109418935

ASUA:

134214407

CQU:	CpipJ_CPIJ003056

CPII:

120432614

CBRI:

134829891

CNS:

116347823

BCOO:

119081235

LLL:

129792651

PPAP:

129801789

NVI:

100120136

CSOL:

105366624

TPRE:

106650065

FAS:

105264423

DAM:

107039335

VCAN:

122411680

CCIN:

107268819

NPT:

124218962

NFB:

124182898

NLO:

107222152

NVG:

124305414

AROA:

105683351

DCI:

103516518

CLEC:

106661338

NLU:

111044911

HVI:

124367113

MQU:

128995074

FOC:

113210108

TPAL:

117644725

ZNE:

110831195

CSEC:

111870363

PAME:

138715168

IEL:

124167557

HAMR:

139690170

FCD:

110862702

DMK:

116926030

DPZ:

124315410

PVM:

113815316

PJA:

122252315

PCHN:

125025755

PMOO:

119576789

HAME:

121875688

PCLA:

123764960

CQD:

128692025

PTRU:

123519041

ESN:

126998836

MNZ:

135202439

MRJ:

136847317

ISC:

8053025

DSV:

119445622

RSAN:

119377584 119390488

RMP:

119169799

VDE:	111247588 111254724

VJA:	111264476 111268118

GOE:	100898467 100905877

TUT:

107363285

DPTE:

113794090

DFR:

124490209

CSCU:

111622487

CVS:

136985026

PTEP:

107437550

ABRU:

129960448

UDV:

129219275

SDM:

118201694

LPOL:

106475760

PMEO:

129587684

HRO:	HELRODRAFT_89375

PVUL:

126824716

LSAX:

138976104

GAE:

121389292

HRF:	124140223 124140224 124140226 124141700

HRJ:	124260823 124260824 124278058

HASI:

137256388 137284947 137293342

HCRA:

139455224 139472337 139472362 139472363 139472401

CRG:	105321517 105332656

CANU:

128186867 128188117 128188594

CVN:	111136775 111137023 111137166

OED:	125654276 125659193 125659727

MYI:

110457155

PMAX:

117333059 117333060 117333062 117333069

AIRR:

138331179 138331399 138331633

MMER:

123525098 123534278 123534660 123535125 123535257 123535266 123552007

RPHI:

132742228 132742229 132743368 132753356 132759419 132759420

DPOL:

127839711 127856352 127861538

MAEA:

128229618 128232487 128232575

OSN:

115219210

LJP:	135468058 135477165

LAK:

106151343

LLON:

135485103 135502377

RGL:	CS053_01865

PRE:	PCA10_13780(ksi)

PFUW:

KF707C_12130

PLAL:

FXN65_06400

PVR:	PverR02_11605

PPUU:

PputUW4_01655

PKC:

PKB_4244

PSET:

THL1_1429

PKE:	DLD99_14770

PAZE:

KSS91_19320

PIZ:	LAB08_R41010

PSHS:

JJN09_05405

PSKP:

KU43P_19370

PSWO:

SD196_12890

PMOR:

PMm318_A52950

KAK:	Kalk_07505

SPL:

Spea_2174

SHL:

Shal_2145

CBER:

B5D82_11220

SPOI:

IMCC21906_02012

SNAN:

I6N98_07355 I6N98_09215

ZAL:	AZF00_08390 AZF00_11020

OSG:	BST96_05805

HJA:	BST95_12875 BST95_17215

HALC:

EY643_04910 EY643_09605

AFUS:

EYZ66_12985

PAQM:

E0F26_07455

MSEC:

LN244_04855

ENW:	MJO57_19210

EMP:	EZMO1_1200(nsdHL) EZMO1_1305(sdiS)

SOK:	D0B54_00185 D0B54_09480

SINI:

GT972_09350

FCE:	JN531_005765

GPB:	HDN1F_02730(ksi)

REH:	H16_B0602(h16_B0602)

CNC:	CNE_2c05470

REU:	Reut_A1514

CTI:	RALTA_B0406

CBW:	RR42_s2306

COX:	E0W60_08050

CUK:	KB879_20450

CUPP:

CTP10_R38520

BVI:	Bcep1808_3720

BVE:

AK36_4984

BUR:	Bcep18194_B0101

BCM:	Bcenmc03_4714

BCH:	Bcen2424_5558

BCJ:

BCAM2743

BCEN:

DM39_5137

BCEW:

DM40_3330

BCEO:

I35_6629

BAM:

Bamb_4882

BAC:	BamMC406_5430

BMJ:	BMULJ_05277

BMU:

Bmul_3248

BMK:

DM80_4627

BMUL:

NP80_3306

BCT:

GEM_5661

BCED:

DM42_5239

BCEP:

APZ15_24235

BDL:

AK34_5047

BPYR:

ABD05_21995

BCON:

NL30_17595

BDF:	WI26_26300

BLAT:

WK25_29230

BTEI:

WS51_10405

BSEM:

WJ12_33620

BPSL:

WS57_00690

BMEC:

WJ16_32080

BSTL:

BBJ41_27575

BANN:

JFN94_17840

BARI:

NLX30_23420

BAEN:

L3V59_28730

BSER:

R0290_20195

BUK:

MYA_3353

BURK:

DM992_25380

BURM:

GJG85_24965

BFN:

OI25_4583

PMEG:

FNZ07_03235

PBRY:

NDK50_32845

PPAI:

E1956_37270

PWU:	A8O14_06055

CABA:

SBC2_49080(ksi)

AJS:

Ajs_2963

ACIQ:

ACDW_35430

ACIV:

EXV95_13700

CTT:	CtCNB1_1323

CTES:

O987_07595

CSER:

CCO03_15920

CRJ:	QMY55_06900

ADK:	Alide2_3000

HYN:	F9K07_07025

DPY:	BA022_01740

DIA:	Dtpsy_2390

MELA:

C6568_15080

SMIO:

CATMQ487_31850

DOE:	DENOEST_1376(ksi) DENOEST_2468 DENOEST_3713

DENI:

B9N43_04415 B9N43_04945 B9N43_13430

MESO:

BSQ44_10800

PMOB:

HG718_03120

MAQU:

Maq22A_c07735

MEE:	DA075_27260

MTEA:

DK419_13925

POZ:	I0K15_04330

FRB:	AB6B37_08100

NAR:	Saro_3596 Saro_3765

NPP:	PP1Y_Mpl2956

NOV:	TQ38_027200 TQ38_027400

NOT:	C7W88_20825 C7W88_20845

NGF:	FRF71_08555

NOVO:

IM701_15520 IM701_20410

SPOG:

EEB18_002620 EEB18_002815

SWI:	Swit_2520 Swit_3295

SPHD:

HY78_09075 HY78_12935

SPHM:

G432_01540 G432_04615 G432_04695 G432_04850

SSAN:

NX02_14810

SPKC:

KC8_00670 KC8_01015 KC8_01175 KC8_03160 KC8_10225 KC8_10955 KC8_13360

SPHA:

D3Y57_15405

SLAN:

GV829_01955

SBIN:

SBA_ch2_4480

SPCL:

F9288_18610

SPHB:

EP837_02960 EP837_03245 EP837_03374

SPCA:

GL174_15445 GL174_15675

SPJS:

NUH86_21925

SPHG:

AZE99_02185

SFLA:

SPHFLASMR4Y_01939(ksi)

SPHY:

CHN51_03380

PARJ:

J4G78_13310

PHAO:

HF685_05615 HF685_13385

ALH:	G6N82_09425

ALTC:

P7228_01010

ELQ:	Ga0102493_111103

ERK:	CD351_14410

PHZ:	CHX26_05225

NTD:	EGO55_02335 EGO55_06035 EGO55_07020 EGO55_13785 EGO55_15950 EGO55_16340

CAEN:

K5X80_05945 K5X80_06675 K5X80_14630

TRS:	Terro_1090

NDE:

NIDE1836

NMV:	NITMOv2_2424

OIH:

OB0288

OON:	NP440_18950

BVJ:	I5776_03735

MVT:	I6J10_12355

BBOR:

RFB14_05375

EUZ:	DVS28_a4276 DVS28_a4726

MTU:	Rv0760c Rv1106c

MTV:	RVBD_0760c RVBD_1106c

MTC:	MT0785 MT1137

MRA:	MRA_0770 MRA_1117

MTF:	TBFG_10775 TBFG_11128

MTB:	TBMG_00775 TBMG_02877

MTK:	TBSG_00779 TBSG_02893

MTZ:	TBXG_000768 TBXG_002857

MTG:	MRGA327_04735 MRGA327_06925

MTI:	MRGA423_04755 MRGA423_06915

MTE:	CCDC5079_0703 CCDC5079_1022

MTUR:

CFBS_0799 CFBS_1174

MTL:	CCDC5180_0695 CCDC5180_1014

MTO:	MTCTRI2_0779 MTCTRI2_1136

MTD:	UDA_0760c UDA_1106c

MTN:	ERDMAN_0842 ERDMAN_1239

MTJ:	J112_04090 J112_05975

MTUB:

MT7199_0781 MT7199_1133

MTUC:

J113_05370 J113_07785

MTUE:

J114_04060 J114_05980

MTX:	M943_03980 M943_05820

MTUH:

I917_05390 I917_07855

MTUL:

TBHG_00752 TBHG_01091

MTUT:

HKBT1_0799 HKBT1_1172

MTUU:

HKBT2_0800 HKBT2_1178

MTQ:	HKBS1_0799 HKBS1_1174

MBO:	BQ2027_MB0783C BQ2027_MB1136C

MBB:	BCG_0812c BCG_1166c

MBT:	JTY_0782 JTY_1139

MBM:	BCGMEX_0783c BCGMEX_1138c

MBK:	K60_008130 K60_011910

MBX:	BCGT_0561 BCGT_0934

MAF:	MAF_07720 MAF_11210

MMIC:

RN08_0849 RN08_1242

MCE:	MCAN_07641 MCAN_11161

MCQ:	BN44_10830 BN44_11231

MCV:	BN43_20195 BN43_30163

MCX:	BN42_20518 BN42_20954

MCZ:	BN45_20029 BN45_30150

MORY:

MO_000815 MO_001188

MLE:

ML1942

MLB:

MLBr01942

MPA:	MAP_0541c MAP_0594c MAP_2478 MAP_2688 MAP_2705c

MAO:	MAP4_1111 MAP4_1128 MAP4_1345 MAP4_3271 MAP4_3326

MAVI:

RC58_05520 RC58_05605 RC58_06655 RC58_16235 RC58_16495

MAVU:

RE97_05515 RE97_05600 RE97_06645 RE97_16265 RE97_16530

MAV:	MAV_0635 MAV_0704 MAV_1209 MAV_1225 MAV_1444

MAVM:

MAA44156_00554 MAA44156_00608 MAA44156_02817(ksi_1) MAA44156_03036 MAA44156_03054(ksi_2)

MIT:	OCO_05450 OCO_05970 OCO_11160 OCO_11340 OCO_15430

MIA:	OCU_05490 OCU_06010 OCU_11140 OCU_11320 OCU_15870

MID:	MIP_01001 MIP_01077 MIP_01799 MIP_01824 MIP_02150

MYO:	OEM_05520 OEM_06060 OEM_11270 OEM_11450 OEM_13520

MCHI:

AN480_02725 AN480_02980 AN480_06660 AN480_06750 AN480_07710

MIR:	OCQ_05600 OCQ_06120 OCQ_11170 OCQ_11350 OCQ_13340

MMAL:

CKJ54_02650 CKJ54_02920 CKJ54_05425 CKJ54_05520 CKJ54_06510

MLP:	MLM_0778A MLM_0827 MLM_1173 MLM_1377

MMAN:

MMAN_26200 MMAN_48410 MMAN_48950 MMAN_54410 MMAN_54580

MSER:

MTY59_24770 MTY59_25380 MTY59_30300 MTY59_30480 MTY59_32560

MSA:	Mycsm_05045 Mycsm_05075 Mycsm_05686 Mycsm_05758

MUL:	MUL_0172 MUL_0195 MUL_0468 MUL_4084

MMI:	MMAR_4359 MMAR_4382 MMAR_4937 MMAR_5010

MMAE:

MMARE11_41790 MMARE11_42020 MMARE11_47470 MMARE11_48200

MLI:	MULP_04570 MULP_04597 MULP_05181

MPSE:

MPSD_44990 MPSD_45250 MPSD_51280 MPSD_52080

MSHO:

MSHO_01550 MSHO_16920

MMC:	Mmcs_4109 Mmcs_4139 Mmcs_4586

MKM:	Mkms_4185 Mkms_4214 Mkms_4674

MJL:	Mjls_4340 Mjls_4370 Mjls_4969

MMM:	W7S_02670 W7S_02930 W7S_05455 W7S_05545 W7S_06520

MKN:	MKAN_07985 MKAN_08100 MKAN_11300 MKAN_11785

MYV:	G155_04240 G155_04785 G155_05080 G155_22700 G155_22900

MYE:	AB431_06300 AB431_06460 AB431_26000 AB431_26300

MHAD:

B586_05030 B586_07090

MDX:	BTO20_08205 BTO20_08365 BTO20_30850 BTO20_31135

MSHG:

MSG_03923 MSG_03940 MSG_04437 MSG_04511

MFJ:	MFLOJ_41130 MFLOJ_41750 MFLOJ_47450 MFLOJ_49700

MSTO:

MSTO_45110 MSTO_45770 MSTO_51430 MSTO_53860

MSIM:

MSIM_29530 MSIM_30160 MSIM_37390 MSIM_39510

MSAK:

MSAS_19910 MSAS_22240 MSAS_22410 MSAS_27730 MSAS_28660

MKU:	I2456_00570 I2456_20620 I2456_20715 I2456_25150 I2456_25440

MLW:	MJO58_20355 MJO58_21440 MJO58_24515 MJO58_24845

MXE:	MYXE_06220 MYXE_06810 MYXE_13820 MYXE_14010

MNV:	MNVI_06140 MNVI_06350 MNVI_11360 MNVI_12080

MPAG:

C0J29_23965 C0J29_24150 C0J29_26995 C0J29_27485

MNM:	MNVM_07790 MNVM_08060 MNVM_24120

MGOR:

H0P51_22240 H0P51_22335 H0P51_25175 H0P51_25535

MCOO:

MCOO_20360 MCOO_20570 MCOO_25770 MCOO_26700

MBAI:

MB901379_03818 MB901379_03839(ksi) MB901379_04322 MB901379_04404

MSEO:

MSEO_27010 MSEO_27180 MSEO_33500 MSEO_34050

MHEK:

JMUB5695_00521(ksi_1) JMUB5695_00593(ksi_2) JMUB5695_01326(ksi_3) JMUB5695_01344

MGAU:

MGALJ_31210 MGALJ_31460 MGALJ_37140 MGALJ_37850

MLJ:	MLAC_00870 MLAC_06830

MBRD:

MBRA_20480 MBRA_21550 MBRA_27140 MBRA_27460

MSHJ:

MSHI_03080 MSHI_39880

MMAM:

K3U93_17680 K3U93_19010 K3U93_22060 K3U93_22415

MSPG:

F6B93_17425 F6B93_19945 F6B93_20235

MOT:	LTS72_00045 LTS72_00485 LTS72_03400

MLM:	MLPF_2463(hsd)

MPAA:

MKK62_02655 MKK62_02995 MKK62_05630 MKK62_05735 MKK62_25440

MMEH:

M5I08_20635

MKY:	IWGMT90018_50180 IWGMT90018_50490 IWGMT90018_56160

MADI:

A7U43_07060 A7U43_07345 A7U43_09220 A7U43_09340

MWU:	PT015_11765 PT015_11875 PT015_14950 PT015_15310

MYW:	BVC93_08850 BVC93_17760 BVC93_17935 BVC93_29070

MYJ:	BCA37_03155 BCA37_13765 BCA37_24750 BCA37_24940

MSM:	MSMEG_5228 MSMEG_5258 MSMEG_5867

MSG:	MSMEI_5091 MSMEI_5120 MSMEI_5708 MSMEI_6613

MSB:	LJ00_25860 LJ00_26005 LJ00_29015 LJ00_33580

MSN:	LI99_25865 LI99_26010 LI99_29020 LI99_33585

MSH:	LI98_25870 LI98_26015 LI98_29025 LI98_33590

MVA:	Mvan_4635 Mvan_4664 Mvan_5165

MGI:	Mflv_1592 Mflv_2053 Mflv_2075

MSP:	Mspyr1_09780 Mspyr1_14770 Mspyr1_14990

MCB:	Mycch_4050 Mycch_4076 Mycch_4526

MNE:	D174_21420 D174_21515 D174_23880 D174_24190

MYN:	MyAD_21005 MyAD_21100 MyAD_23425 MyAD_23730

MFT:	XA26_08050 XA26_09190 XA26_09800 XA26_46570 XA26_46970

MPHL:

MPHLCCUG_00584 MPHLCCUG_00647 MPHLCCUG_04229 MPHLCCUG_04255(ksi)

MVQ:	MYVA_4444 MYVA_4490 MYVA_5047

MLL:	B1R94_06275 B1R94_06430 B1R94_24625 B1R94_24840

MRH:	MycrhN_2310 MycrhN_2406 MycrhN_3525 MycrhN_3550

MTHN:

4412656_03537 4412656_03575(ksi_2) 4412656_03992

MHAS:

MHAS_03213 MHAS_03236(ksi) MHAS_03651

MDU:	MDUV_00430 MDUV_00690 MDUV_19940 MDUV_50360

MCHT:

MCHIJ_25210 MCHIJ_25440 MCHIJ_42680

MAUU:

NCTC10437_04362 NCTC10437_04389(ksi_2) NCTC10437_04925

MMAG:

MMAD_42700 MMAD_42930 MMAD_47360

MMOR:

MMOR_12410 MMOR_13140 MMOR_18080 MMOR_18320

MFX:	MFAL_05440 MFAL_37730 MFAL_37920

MAIC:

MAIC_05880 MAIC_06430 MAIC_43720 MAIC_44090

MIJ:	MINS_23460 MINS_38420 MINS_38650

MALV:

MALV_29250 MALV_42960 MALV_43520 MALV_48230 MALV_48580

MTY:	MTOK_04970 MTOK_05350 MTOK_23020 MTOK_43150

MPSC:

MPSYJ_16960 MPSYJ_21900 MPSYJ_22130

MARZ:

MARA_48600 MARA_49230 MARA_54110 MARA_54320

MGAD:

MGAD_29810 MGAD_36270 MGAD_36930 MGAD_52480

MHEV:

MHEL_09990 MHEL_10330 MHEL_28340 MHEL_28800

MSAR:

MSAR_10070 MSAR_10440 MSAR_26710 MSAR_27010

MANY:

MANY_26880 MANY_27200 MANY_32080 MANY_32480

MAUB:

MAUB_26160 MAUB_38840 MAUB_43260 MAUB_43590

MPOF:

MPOR_47010 MPOR_47280 MPOR_52700

MPHU:

MPHO_25810 MPHO_26200 MPHO_31260 MPHO_44190

MMUC:

C1S78_002285 C1S78_005245 C1S78_005420 C1S78_025190

MMAT:

MMAGJ_05590 MMAGJ_05980 MMAGJ_34990 MMAGJ_35560

MBOK:

MBOE_03790 MBOE_20880 MBOE_26940 MBOE_27320

MFG:	K6L26_05795 K6L26_06075 K6L26_08865 K6L26_09070

MSEI:

MSEDJ_01210 MSEDJ_54960 MSEDJ_55200

MFLV:

NCTC10271_00528 NCTC10271_00601 NCTC10271_01081(ksi) NCTC10271_01108

MCEE:

MCEL_38440 MCEL_39130 MCEL_43850 MCEL_44150

MBRM:

L2Z93_000797

MMON:

EWR22_22255 EWR22_22405 EWR22_24820

MGO:	AFA91_11385 AFA91_14335 AFA91_14490

MHOL:

K3U96_03710 K3U96_05860 K3U96_06035

MSEN:

K3U95_21790 K3U95_21995 K3U95_24755 K3U95_25035

MPAE:

K0O64_05880 K0O64_06045 K0O64_25465 K0O64_25790

MRF:	MJO55_20980 MJO55_21105 MJO55_23540

MDF:	K0O62_22395 K0O62_22525 K0O62_25095

MCRO:

MI149_06590 MI149_06755 MI149_25770 MI149_26100

MGRO:

FZ046_02265 FZ046_26400 FZ046_26500

MAUS:

JN090_22515 JN090_22650 JN090_25660

MFRE:

EXE63_19090 EXE63_19415 EXE63_22300 EXE63_22420

MBUG:

MU0053_001006 MU0053_001026 MU0053_002840

MYQ:	TUM20985_07630 TUM20985_12300 TUM20985_12530

MFLU:

HZU40_29210 HZU40_29345 HZU40_32310 HZU40_32560

MYH:	QU592_13060 QU592_23600 QU592_23780 QU592_26630 QU592_26920

MPAT:

MPNTM1_02055 MPNTM1_02600 MPNTM1_02624

MKR:	MKOR_36930 MKOR_40250 MKOR_40410

MPAK:

MIU77_02595 MIU77_04130 MIU77_04215

MAB:	MAB_1206 MAB_4170

MMV:	MYCMA_04595 MYCMA_0644

MABB:

MASS_1204 MASS_4169

MABL:

MMASJCM_1233 MMASJCM_4255

MCHE:

BB28_05990 BB28_21470

MIZ:	BAB75_06575 BAB75_23870

MSTE:

MSTE_01173 MSTE_04345

MSAO:

MYCSP_05320 MYCSP_19505

MSAL:

DSM43276_01073(ksi) DSM43276_04010

MJD:	JDM601_1031 JDM601_1056 JDM601_3664

MTER:

4434518_01017(ksi_1) 4434518_01040 4434518_03638(ksi_2)

MMIN:

MMIN_11880 MMIN_26770 MMIN_27080

MHIB:

MHIB_05920 MHIB_06150 MHIB_30560

MHER:

K3U94_05790 K3U94_05970 K3U94_20690

MVM:	MJO54_05920 MJO54_06060 MJO54_20630

MKK:	MU0083_000969 MU0083_000994 MU0083_003416

ASD:	AS9A_0954 AS9A_0994

NFA:	NFA_13370 NFA_22430 NFA_5190

NFR:	ERS450000_01854(ksi_1) ERS450000_02770(ksi_2) ERS450000_03712(ksi_3)

NCY:	NOCYR_0532 NOCYR_1399(ksdI) NOCYR_2411

NBR:	O3I_002875 O3I_008870 O3I_012175 O3I_037425

NNO:	NONO_c05340 NONO_c18580 NONO_c36120 NONO_c59430(ksdI)

NSL:	BOX37_02335 BOX37_11780

NSR:	NS506_01301 NS506_06879

NTP:	CRH09_03480

NOZ:	DMB37_04295 DMB37_23775 DMB37_29655

NOD:	FOH10_03995 FOH10_22975 FOH10_28495

NAH:	F5544_02810 F5544_11490

NAD:	NCTC11293_01280(ksi_1) NCTC11293_04403(ksi_2)

NWL:	NWFMUON74_05280 NWFMUON74_54800

NIE:	KV110_03195 KV110_09440

NTC:	KHQ06_03460 KHQ06_09805 KHQ06_13180 KHQ06_30580 KHQ06_35605

NHU:	H0264_04045 H0264_12670 H0264_34750

NYA:	LTV02_20305 LTV02_28695 LTV02_38265

NGP:	LTT66_04560 LTT66_15690

NSPU:

IFM12276_02120 IFM12276_30520 IFM12276_48830

NYU:	D7D52_00335 D7D52_04690 D7D52_09895

NVU:	V7968_02310 V7968_10290 V7968_16620

RHA:	RHA1_ro03609 RHA1_ro04681 RHA1_ro09001

RER:	RER_09280 RER_13740(ksi) RER_16550 RER_59940

REY:	O5Y_04135 O5Y_06470 O5Y_07905 O5Y_28730

REB:	XU06_04380 XU06_06730 XU06_08140 XU06_29060

RQI:	C1M55_04615 C1M55_06975 C1M55_08375 C1M55_30540

ROP:	ROP_34080(ksi) ROP_47800

ROA:	Pd630_LPD01187 Pd630_LPD08001

RPY:	Y013_10750 Y013_14870 Y013_16310 Y013_19395

RBY:	CEJ39_02755 CEJ39_05755 CEJ39_21545

RAV:	AAT18_04150 AAT18_20785 AAT18_26480

RHW:	BFN03_14720 BFN03_18225

RRZ:	CS378_10130 CS378_15850 CS378_19785

RHQ:	IM25_02490 IM25_06195 IM25_09145

RHOD:

AOT96_10190 AOT96_15020 AOT96_17370 AOT96_18745

RRT:	4535765_00653 4535765_04040(ksi_1) 4535765_04891(ksi_2)

RCR:	NCTC10994_02070 NCTC10994_02099(ksi_1) NCTC10994_02659(ksi_2) NCTC10994_03283(ksi_3)

RTM:	G4H71_07035 G4H71_10315 G4H71_13720

RKO:	JWS14_19205 JWS14_25930

RGO:	KYT97_10340 KYT97_11735 KYT97_12290 KYT97_19295 KYT97_22700 KYT97_24340

ROZ:	CBI38_01410 CBI38_04965 CBI38_30325

RPSK:

JWS13_18570 JWS13_25575

RGOR:

NMQ04_02875 NMQ04_17405 NMQ04_20790

RHOP:

D8W71_00880 D8W71_08190

RHOO:

RA302_04485 RA302_06860 RA302_08285 RA302_29795

RHOU:

KZJ41_04165 KZJ41_21870 KZJ41_27970

RHOW:

A4U64_03895 A4U64_20605 A4U64_24740

RHOJ:

JVH1_12845 JVH1_18565

RHOS:

QWW67_10755 QWW67_17145 QWW67_21485

RHOQ:

QWW98_10760 QWW98_17145 QWW98_21495

RHOY:

QNA09_01695 QNA09_18280 QNA09_23405

RHOH:

CPI83_00335 CPI83_20910 CPI83_22310 CPI83_24600

RHOX:

RBB84_15505 RBB84_20905 RBB84_24010

RHJS:

OYT95_13345 OYT95_19365

RSF:	OED52_02555 OED52_17405 OED52_20565

RHZQ:

GO592_26150 GO592_31410

RHZG:

BO226_15970 BO226_19940 BO226_23795

RHBH:

A0W34_04425 A0W34_06770 A0W34_08145 A0W34_28895

RHPD:

U9J23_03065 U9J23_19540 U9J23_24260

REQ:	REQ_00120 REQ_02260 REQ_07250 REQ_46990

PDEF:

P9209_02065 P9209_03375 P9209_03825 P9209_07985 P9209_28835

PSOW:

ABI214_00030 ABI214_04740 ABI214_10015 ABI214_12830 ABI214_13895 ABI214_14235

WHR:	OG579_09315 OG579_12645

GBR:	Gbro_3969 Gbro_4817

GPO:	GPOL_c41280(ksdI) GPOL_c42810 GPOL_c49840

GOR:	KTR9_3901 KTR9_4702

GOQ:	ACH46_03070 ACH46_17485 ACH46_20535

GTA:	BCM27_04880 BCM27_20450 BCM27_24895

GOC:	CXX93_00530 CXX93_03165

GIT:	C6V83_01325 C6V83_03935

GRU:	GCWB2_07285(ksi1) GCWB2_19935 GCWB2_23650(ksi2)

GOM:	D7316_02575(ksi_1) D7316_03579(ksi_2) D7316_04514

GAV:	C5O27_04875 C5O27_08175 C5O27_20520

GOD:	GKZ92_06910 GKZ92_18865 GKZ92_22545

GOS:	QAD21_19355 QAD21_23475

GOJ:	GR168_18700 GR168_22625

GAM:	GII34_00470 GII34_18845

GPD:	GII33_00455 GII33_03895 GII33_21695

GJI:	H1R19_03805 H1R19_18795 H1R19_22780

GOI:	LK459_05190 LK459_09540 LK459_13810

GHN:	MVF96_19380 MVF96_23540

GAMI:

IHQ52_04440 IHQ52_22880

GMG:	NWF22_06360 NWF22_10355

GSI:	P5P27_01200 P5P27_18985

GOO:	HUN08_15835 HUN08_17945

GOP:	ACE11G_00180 ACE11G_15605

SPIN:

KV203_17185 KV203_19190

TPR:

Tpau_3853

TSM:	ASU32_21945

TPUL:

TPB0596_41940

TSD:	MTP03_43390

DTM:	BJL86_0739 BJL86_3299

DIT:	C3V38_06125 C3V38_09420

DIZ:	CT688_03350 CT688_16895

DPC:	A6048_03300 A6048_17485

DLU:	A6035_03585 A6035_16835

DKN:	NHB83_03155 NHB83_17115

DCD:	VYL96_03365 VYL96_16540

TOY:	FO059_04950 FO059_05695 FO059_17810

SGR:

SGR_6072

SVL:	Strvi_3968 Strvi_3969

SRC:	M271_05600 M271_05605

SMAL:

SMALA_7276 SMALA_7277

SSOI:

I1A49_40145 I1A49_40150

SBH:

SBI_01379

SALS:

SLNWT_0263 SLNWT_0264 SLNWT_0271

STRC:

AA958_00655

SGM:	GCM10017557_10870 GCM10017557_10880

SAUO:

BV401_39990 BV401_39995

SFK:	KY5_6110 KY5_7820c

SQZ:	FQU76_00315 FQU76_33425

SKA:	CP970_00345 CP970_10385

SAQU:

EJC51_45790

SBY:	H7H31_00630 H7H31_00635 H7H31_09555

SNF:	JYK04_07456(auaH_3)

SHUN:

DWB77_01913(ksi)

SMOB:

J7W19_02535 J7W19_02540

SMAO:

CAG99_00635 CAG99_00640

SCIR:

STRCI_001090 STRCI_001091

SANT:

QR300_04675 QR300_04680

SOV:	QZH56_33335

STRZ:

OYE22_00700 OYE22_00705 OYE22_09190

SPRF:

K4G22_27165 K4G22_27170

SLUO:

PS467_03875 PS467_03880

KSE:	Ksed_03450

JTE:	ASJ30_03030

JLI:	EXU32_11870

TEH:	GKE56_14565

BRI:	FDF13_06580

BLUT:

EW640_07445

BCAU:

I6G59_00370

NCA:	Noca_3954 Noca_4417

NDK:	I601_0503(ksi) I601_0994

NOY:	EXE57_06800

NBE:	Back2_27960 Back2_28710

NANO:

G5V58_18180 G5V58_24130

NARO:

CFH99_21180 CFH99_21585

NPI:	G7071_06255

NPC:	KUV85_11170 KUV85_11490

NMAR:

HPC71_17700 HPC71_19525

NFC:	KG111_16240 KG111_16625

NBI:	SHK19_19050 SHK19_19675

NOF:	MF408_11690

NOCR:

OSR43_18000 OSR43_19835

NOCW:

ABFU82_16015 ABFU82_16630 ABFU82_20910

NOCA:

ncot_01100 ncot_07625 ncot_07665

NOCL:

KM427_22020 KM427_23950

NOCD:

QJ852_03280 QJ852_03880

NOCQ:

QI633_03080 QI633_23465

PSIM:

KR76_23530 KR76_24125 KR76_27120

AEB:	C6I20_03455

KQI:	F1D05_00490

TCU:

Tcur_1249

ACTW:

F7P10_02755 F7P10_02765 F7P10_07420 F7P10_31110

AGRA:

AGRA3207_007743 AGRA3207_007744

AMAZ:

LUW76_11930 LUW76_17610

ACIR:

OG979_13795 OG979_24475 OG979_29595

AWS:	ACN3XK_09920 ACN3XK_10680 ACN3XK_18130 ACN3XK_18765 ACN3XK_68665

SPIQ:

OHA34_00040 OHA34_12430

FAL:

FRAAL4373

SEN:

SACE_4441

AMD:

AMED_6805

AMN:

RAM_34920

AMM:

AMES_6703

AMZ:

B737_6703

AOI:

AORI_1932

AJA:	AJAP_29875

AMQ:	AMETH_1705

AMYC:

CU254_17015 CU254_23470 CU254_27500

AMYB:

BKN51_01815

AAB:	A4R43_38955

AMYY:

YIM_36650(ksi) YIM_38965

AORI:

SD37_31505

AACD:

LWP59_08550

APRT:

MUY14_02695

AROO:

NQK81_13015

ATHM:

L1857_11190

ARHD:

VSH64_23660

AMOG:

QRX60_50785

ACYN:

ORV05_24610

ACOR:

LCL61_16580

AMYZ:

HUW46_06923

ACAB:

QRX50_21715

AMYD:

K1T34_04245

ABAR:

AMYBAR_001674

AMYE:

MJQ72_31410

AMYS:

CVV72_19505

PSDS:

K1T35_06350

KAL:

KALB_3395

KUT:	JJ691_41190

KBR:	Q4V65_07660

KPHY:

AOZ06_52295

LED:	BBK82_38795

ALO:

CRK62153

PMAD:

BAY61_08615

SACE:

GIY23_13305

CROS:

N8J89_13170

SAQ:

Sare_2441

AMS:	AMIS_34110

ASIC:

Q0Z83_012650 Q0Z83_020550

BFJ:	B19861_13380

JCY:	M6B22_21205

BSOL:

FSW04_25160

PARN:

NBH00_01325

AQZ:	KSP35_07770

IAM:	HC251_14040

IMA:	PO878_09280

DHI:	LH044_14955 LH044_15465

CYN:	Cyan7425_3259

CALO:

Cal7507_5935

CALH:

IJ00_18680

RIV:	Riv7116_5342

LOB:	NEF87_000807

» show all

Reference

1 [PMID:5867327]

Authors

Ewald W, Werbin H, Chaikoff IL.

Title

Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex.

Journal

Biochim Biophys Acta 111:306-12 (1965)
DOI:10.1016/0304-4165(65)90497-6

Reference

2 [PMID:14404954]

Authors

KAWAHARA FS, TALALAY P.

Title

Crystalline Delta 5-3-ketosteroid isomerase.

Journal

J Biol Chem 235:PC1-2 (1960)

Reference

3 [PMID:13276386]

Authors

TALALAY P, WANG VS.

Title

Enzymic isomerization of delta5-3-ketosteroids.

Journal

Biochim Biophys Acta 18:300-1 (1955)
DOI:10.1016/0006-3002(55)90079-2

Reference

4 [PMID:10822008]

Authors

MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ

Title

Cholesterol oxidase: sources, physical properties and analytical applications.

Journal

J Steroid Biochem Mol Biol 72:169-95 (2000)
DOI:10.1016/S0960-0760(00)00044-3

Other DBs

ExplorEnz - The Enzyme Database:

5.3.3.1

IUBMB Enzyme Nomenclature:

5.3.3.1

ExPASy - ENZYME nomenclature database:

5.3.3.1

BRENDA, the Enzyme Database:

5.3.3.1

CAS:

9031-36-1

All links

Gene (791)   
   MGENES (711)   
   RefGene (80)   
Protein sequence (11608)   
   UniProt (11001)   
   SWISS-PROT (33)   
   RefSeq(pep) (344)   
   PDBSTR (190)   
   PMD (40)   
DNA sequence (871)   
   RefSeq(nuc) (589)   
   GenBank (145)   
   EMBL (137)   
3D Structure (84)   
   PDB (84)   
Protein domain (14)   
   InterPro (14)   
All databases (13368)   

Download RDF

REACTION: R09920

Entry

R09920                      Reaction

Name

cholesterol:NAD+ 3-oxidoreductase;
cholest-4-en-3-one delta5-delat4-isomerase

Definition

Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+

Equation

C00187 + C00003 <=> C00599 + C00004 + C00080

Comment

multi-step reaction (see R03176+R02644)

Reaction class

RC00001

C00003_C00004

RC00146

C00187_C00599

Enzyme

1.1.1.145 5.3.3.1

Pathway

rn00984

Steroid degradation

rn01120

Microbial metabolism in diverse environments

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R09920  Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+
5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R09920  Cholesterol + NAD+ <=> Cholest-4-en-3-one + NADH + H+

Orthology

K16045

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

All links

No link information was found.

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