KEGG   ORTHOLOGY: K16046
Entry
K16046                      KO                                     
Symbol
CYP142
Name
cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28]
Pathway
map00984  Steroid degradation
map01120  Microbial metabolism in diverse environments
Reaction
R11358  cholest-4-en-3-one,reduced-[2Fe-2S]-ferredoxin:oxygen oxidoreductase [(25R)-26-hydroxycholest-4-en-3-one forming]
R11359  (25R)-26-hydroxycholest-4-en-3-one,reduced-[2Fe-2S]-ferredoxin:oxygen oxidoreductase [(25R)-26-oxocholest-4-en-3-one forming]
R11360  (25R)-26-oxocholest-4-en-3-one,reduced-[2Fe-2S]-ferredoxin:oxygen oxidoreductase [(25R)-3-oxocholest-4-en-26-oate forming]
R11361  cholest-4-en-3-one,reduced-2Fe-2S]-ferredoxin:oxygen oxidoreductase [(25R)-3-oxocholest-4-en-26-oate forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16046  CYP142; cholest-4-en-3-one 26-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K16046  CYP142; cholest-4-en-3-one 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.28  cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
     K16046  CYP142; cholest-4-en-3-one 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP142 family
   K16046  CYP142; cholest-4-en-3-one 26-monooxygenase
Other DBs
COG: COG2124
Genes
MTU: Rv3518c(cyp142)
MTV: RVBD_3518c
MTC: MT3619
MRA: MRA_3557(cyp142)
MTF: TBFG_13551
MTB: TBMG_03557
MTK: TBSG_03584
MTZ: TBXG_003533
MTG: MRGA327_21740
MTI: MRGA423_22200
MTE: CCDC5079_3259
MTUR: CFBS_3734(cyp142)
MTL: CCDC5180_3211
MTO: MTCTRI2_3582(cyp142)
MTD: UDA_3518c(cyp142)
MTN: ERDMAN_3857(cyp142)
MTJ: J112_18940
MTUB: MT7199_3578
MTUC: J113_24605
MTUE: J114_18810
MTX: M943_18090
MTUH: I917_24680
MTUL: TBHG_03458
MTUT: HKBT1_3719(cyp142)
MTUU: HKBT2_3728(cyp142)
MTQ: HKBS1_3731(cyp142)
MBO: BQ2027_MB3547C(cyp142b) BQ2027_MB3548C(cyp142a)
MBB: BCG_3581c(cyp142b) BCG_3582c(cyp142a)
MBT: JTY_3582(cyp142b) JTY_3583(cyp142a)
MBM: BCGMEX_3579c(cyp142b) BCGMEX_3580c(cyp142a)
MBK: K60_036520 K60_036530
MBX: BCGT_3381
MMIC: RN08_3892 RN08_3893
MCE: MCAN_35291(cyp142)
MCQ: BN44_110006(cyp)
MCV: BN43_90011(cyp)
MCX: BN42_90009(cyp)
MCZ: BN45_100009(cyp)
MPA: MAP_0547
MAO: MAP4_3320
MAVI: RC58_16465
MAVU: RE97_16500
MAV: MAV_0641
MIT: OCO_01300 OCO_05500
MIA: OCU_01340 OCU_05550
MID: MIP_00395 MIP_01006
MYO: OEM_01390 OEM_05580
MCHI: AN480_00700 AN480_02755
MIR: OCQ_01290 OCQ_05660
MMAL: CKJ54_00570 CKJ54_02680
MLP: MLM_0784
MMAN: MMAN_43780(cyp142) MMAN_48470
MSER: MTY59_18160(cyp142) MTY59_19930(cyp142) MTY59_24830
MSA: Mycsm_05751
MUL: MUL_4077(cyp142A3)
MMI: MMAR_5003(cyp142A3)
MMAE: MMARE11_48130(cyp142A3)
MLI: MULP_05251(cyp142A3)
MPSE: MPSD_52010(cyp142)
MSHO: MSHO_04690(cyp142)
MMC: Mmcs_4631
MKM: Mkms_4719
MJL: Mjls_5013
MMM: W7S_00635 W7S_02700
MKN: MKAN_11750
MYV: G155_04820
MYE: AB431_06755 AB431_26265
MHAD: B586_04705
MDX: BTO20_31100
MSHG: MSG_04505(cyp142)
MFJ: MFLOJ_41190(cyp142)
MSTO: MSTO_45170(cyp142)
MSIM: MSIM_29590(cyp142) MSIM_48400
MSAK: MSAS_28600
MKU: I2456_06630 I2456_25405
MLW: MJO58_24815
MXE: MYXE_06290(cyp142)
MNV: MNVI_12010(cyp142)
MPAG: C0J29_27450
MNM: MNVM_24280
MGOR: H0P51_00720 H0P51_25500
MCOO: MCOO_26630(cyp142)
MBAI: MB901379_04397
MSEO: MSEO_33990(cyp142)
MHEK: JMUB5695_00528(cyp142)
MGAU: MGALJ_37780(cyp142)
MLJ: MLAC_00250(cyp142)
MBRD: MBRA_14020(cyp142) MBRA_20550
MSHJ: MSHI_39220(cyp142)
MMAM: K3U93_22385
MSPG: F6B93_20205
MOT: LTS72_00080
MPAA: MKK62_02690
MKY: IWGMT90018_01530(cyp142) IWGMT90018_56770
MADI: A7U43_07090
MWU: PT015_00695 PT015_15275
MYW: BVC93_08820
MSM: MSMEG_5918
MSG: MSMEI_5758(cyp142)
MSB: LJ00_29265
MSN: LI99_29270
MSH: LI98_29275
MVA: Mvan_5217
MGI: Mflv_1541
MSP: Mspyr1_09250
MCB: Mycch_4578
MNE: D174_24160
MYN: MyAD_23700
MFT: XA26_09260
MPHL: MPHLCCUG_00591
MVQ: MYVA_5103
MLL: B1R94_06765 B1R94_24805
MRH: MycrhN_2317
MTHN: 4412656_04035
MHAS: MHAS_03703
MDU: MDUV_49910
MCHT: MCHIJ_20130
MAUU: NCTC10437_04981
MMAG: MMAD_47780
MMOR: MMOR_12480(cyp142_2)
MFX: MFAL_33760
MAIC: MAIC_05950 MAIC_42210
MIJ: MINS_43060
MALV: MALV_43030
MTY: MTOK_23080
MPSC: MPSYJ_16480
MARZ: MARA_48660
MGAD: MGAD_36860(cyp142)
MHEV: MHEL_08790(cyp142) MHEL_28410
MSAR: MSAR_10370 MSAR_27650
MANY: MANY_25750 MANY_32410
MAUB: MAUB_26100
MPOF: MPOR_53180
MPHU: MPHO_44250
MMUC: C1S78_025160
MMAT: MMAGJ_35060
MBOK: MBOE_03720
MFG: K6L26_05830
MSEI: MSEDJ_01750
MFLV: NCTC10271_00535
MCEE: MCEL_38510(cyp142)
MMON: EWR22_25045
MGO: AFA91_11165
MHOL: K3U96_03410
MSEN: K3U95_25000
MPAE: K0O64_06385 K0O64_25755
MRF: MJO55_23815
MDF: K0O62_25325
MCRO: MI149_07090 MI149_26065
MGRO: FZ046_02520
MAUS: JN090_25920
MKR: MKOR_35990(cyp142)
MPAK: MIU77_02280
MJD: JDM601_3652(cyp142A3)
MTER: 4434518_03626(cyp142A3)
MMIN: MMIN_11820
MHIB: MHIB_30500
MHER: K3U94_20645
MVM: MJO54_20580
RHA: RHA1_ro04588
RER: RER_07670
REY: O5Y_03730
REB: XU06_03970
RQI: C1M55_04210
ROP: ROP_45330
ROA: Pd630_LPD01065
RHW: BFN03_15100
RHOD: AOT96_14605
RKO: JWS14_25270
RGO: KYT97_23305
ROZ: CBI38_04260
RPSK: JWS13_19265
RHOP: D8W71_26880
RHOO: RA302_04080
REQ: REQ_06880
YIA: LO772_20455
TCU: Tcur_2583
ACTW: F7P10_01990
AGRA: AGRA3207_002188
AMAZ: LUW76_33645
ACIR: OG979_24870
SPIQ: OHA34_17765
SRO: Sros_7155
NOA: BKM31_57860
NGN: LCN96_42985
FRI: FraEuI1c_2049 FraEuI1c_2543
ACYN: ORV05_11410
PBRO: HOP40_00280
ACTY: OG774_13860
ABAI: IMCC26256_11539
AYM: YM304_15670
AQZ: KSP35_16625
IAM: HC251_00840 HC251_06765
IMA: PO878_00495 PO878_15970
DHI: LH044_09145 LH044_15165 LH044_18150 LH044_18825
 » show all
Reference
PMID:20843794 (CYP142A1)
  Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
  Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
  Journal
J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117
  Sequence
[mtu:Rv3518c]

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Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
   KEGG RCLASS (4)   
Gene (770)   
   KEGG GENES (232)   
   KEGG MGENES (535)   
   OC (3)   
Literature (1)   
   PubMed (1)   
All databases (788)   

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