KEGG   ORTHOLOGY: K16047
Entry
K16047                      KO                                     
Symbol
hsaA
Name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12]
Pathway
map00984  Steroid degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R09819  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16047  hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.12  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
     K16047  hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Other DBs
COG: COG1960
Genes
RGL: CS053_01745
VAF: D1115_22760
PRE: PCA10_43690
PFUW: KF707C_11830
PCQ: PcP3B5_25640(hsaA_1) PcP3B5_37050(hsaA_3)
PPUT: L483_14090
PPUN: PP4_27210
PFE: PSF113_3461 PSF113_3462
PVR: PverR02_11725
PPUU: PputUW4_01682
PKC: PKB_4323
PSET: THL1_4411
PTAE: NCTC10697_02062(hsaA_3)
SPL: Spea_2129
SHL: Shal_2101
PHA: PSHAa0877
PTN: PTRA_a1004(hsaA)
PNG: PNIG_a1056(hsaA)
EMP: EZMO1_1273(tesAA)
RSY: RSUY_11610(hsaA)
REH: H16_B0638(h16_B0638)
CNC: CNE_2c05830(hsaA)
CGD: CR3_0799(hsaA)
BCJ: BCAM1647
BCEN: DM39_6202
BCEO: I35_5507
BAM: Bamb_5026
BCT: GEM_4008
BCED: DM42_6311
BCON: NL30_03950
BTEI: WS51_05860
BPSL: WS57_05845
BMEC: WJ16_26975
BGO: BM43_6910
BFN: OI25_4616
CABA: SBC2_48740(hsaA_1)
BAV: BAV0595
CTES: O987_07755
DAR: Daro_0902
THAG: CKCBHOJB_02265(hsaA)
BJA: bll6096(bll6096)
BRS: S23_21790
BRAD: BF49_5537
BARH: WN72_34045
NWI: Nwi_0937
NHA: Nham_3406
XAU: Xaut_0933
SNO: Snov_0210
CSE: Cseg_1728
SPHM: G432_01990
STAX: MC45_16520
SPHI: TS85_13285
SSAN: NX02_12720
SSY: SLG_18380
SPHB: EP837_03391(hsaA)
SMIC: SmB9_33370
MTU: Rv3570c(hsaA)
MTC: MT3675
MRA: MRA_3609
MTUR: CFBS_3787
MTD: UDA_3570c
MTUC: J113_25000
MTUE: J114_19095
MTUH: I917_25085
MTUL: TBHG_03511
MTUT: HKBT1_3772
MTUU: HKBT2_3781
MBO: BQ2027_MB3601C(hsaa)
MBB: BCG_3635c
MBT: JTY_3636
MBX: BCGT_3437
MAF: MAF_35830
MMIC: RN08_3947
MCQ: BN44_110065(hsaA)
MCV: BN43_90071(hsaA)
MCX: BN42_90068(hsaA)
MCZ: BN45_100084(hsaA)
MORY: MO_003729(hsaA)
MHAD: B586_04445
MSHG: MSG_00802(hsaA_1) MSG_02472 MSG_04563(hsaA_2)
MBAI: MB901379_03069(hsaA_2) MB901379_04454(hsaA_4)
MSHJ: MSHI_38520
MPHL: MPHLCCUG_00491(hsaA_1) MPHLCCUG_01764(hsaA_2) MPHLCCUG_02628(hsaA_4) MPHLCCUG_03656(hsaA_5) MPHLCCUG_03657(hsaA_6)
MTHN: 4412656_00960(hsaA_1) 4412656_01361(hsaA_3) 4412656_04094(hsaA_5)
MHAS: MHAS_00635(hsaA_1) MHAS_02456(hsaA_2) MHAS_03779(hsaA_3)
MMAG: MMAD_48590
MFLV: NCTC10271_00465(hsaA_1) NCTC10271_02188(hsaA_2) NCTC10271_03729(hsaA_4)
MSAL: DSM43276_00265(hsaA_1) DSM43276_00502(hsaA_2)
MTER: 4434518_02237(hsaA_2) 4434518_03729(hsaA_3) 4434518_04155(hsaA_4)
ASD: AS9A_0924
CCOE: CETAM_13240(hsaA4)
COK: COCCU_04915(hsaA2) COCCU_11660(hsaA3)
NFR: ERS450000_00305(hsaA_1) ERS450000_00680(hsaA_2) ERS450000_00694(hsaA_3) ERS450000_01850(hsaA_6) ERS450000_03762(hsaA_8)
NAD: NCTC11293_01247(hsaA_2) NCTC11293_04393(hsaA_4)
NWL: NWFMUON74_04950(hsaA)
RHB: NY08_3127
RHU: A3Q40_00865(hsaA)
RRT: 4535765_00582(hsaA_1) 4535765_00630(hsaA_2) 4535765_00632(hsaA_3) 4535765_01483(hsaA_4) 4535765_04054(hsaA_6) 4535765_04572(hsaA_7) 4535765_04586(hsaA_8)
RCR: NCTC10994_02088(hsaA_1) NCTC10994_02090(hsaA_2) NCTC10994_02138(hsaA_3) NCTC10994_03240(hsaA_4) NCTC10994_03313(hsaA_5)
GBR: Gbro_0920
GOR: KTR9_0820(hsaA)
GRU: GCWB2_04175(hsaA1) GCWB2_08185(hsaA2)
GOM: D7316_02455(hsaA_1) D7316_02566(hsaA_2)
TPR: Tpau_3845
SRT: Srot_0299
SFI: SFUL_4664
SHY: SHJG_0396
SMAL: SMALA_8231
SALS: SLNWT_2215
STRE: GZL_08548
STRM: M444_37895
SALU: DC74_7445
SALL: SAZ_38430
SALJ: SMD11_0294
SLX: SLAV_27430(hsaA1)
SGE: DWG14_00038(hsaA_1) DWG14_00204(hsaA_2) DWG14_08423(hsaA_3)
SMIB: SMIR_35805
NDK: I601_0579(hsaA_1) I601_3470(hsaA_2)
SRO: Sros_6977
TBI: Tbis_1633
AJA: AJAP_26405(hsaA)
AMYY: YIM_14450(hsaA1) YIM_23025(hsaA2) YIM_36670(hsaA6) YIM_40880(hsaA8)
AORI: SD37_13485
PAUT: Pdca_45790
KAL: KALB_5124
AHG: AHOG_16455(hsaA1)
SAQ: Sare_2879
ACTE: ACTI_41210
BALA: DSM104299_04017(hsaA_2)
TRO: trd_A0928
 » show all
Reference
  Authors
Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD
  Title
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
  Journal
J Biol Chem 285:22264-75 (2010)
DOI:10.1074/jbc.M109.099028
  Sequence
[mtu:Rv3570c]
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

KEGG   ORTHOLOGY: K16048
Entry
K16048                      KO                                     
Symbol
hsaB
Name
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-]
Pathway
map00984  Steroid degradation
map01100  Metabolic pathways
Reaction
R09819  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16048  hsaB; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component
Other DBs
COG: COG1853
Genes
THEH: G7079_10275
RGL: CS053_01750
VAF: D1115_22455
PGH: FH974_24225
PMY: Pmen_3451
PRE: PCA10_14530
PFUW: KF707C_41950
PCQ: PcP3B5_03810(hsaB_1)
PPF: Pput_2088 Pput_3055
PPG: PputGB1_2266 PputGB1_3091
PPT: PPS_3137
PPX: T1E_1781 T1E_2701(nmoB)
PPUH: B479_15580
PPUD: DW66_3407
PMON: X969_15075
PMOT: X970_14720
PSYR: N018_03235
PAST: N015_15635
PFL: PFL_3512
PPRC: PFLCHA0_c35530(hsaB)
PPRO: PPC_3666
PFS: PFLU_2313
PMUD: NCTC8068_02158(hsaB_1)
PKC: PKB_0275
PSES: PSCI_4782
PDW: BV82_3209
PTAE: NCTC10697_02059(C1-hpah) NCTC10697_02518(hsaB_2)
SPL: Spea_2119
SHL: Shal_2091
PHA: PSHAa2140(tesA)
PTN: PTRA_a2593(hsaB)
PNG: PNIG_a2787(hsaB)
PLG: NCTC10937_03417(hsaB_2)
BAV: BAV1593
AMIM: MIM_c33700
CTES: O987_07750
CFU: CFU_2819(tesA)
APET: ToN1_05180
THAG: CKCBHOJB_02377(C1-hpah_1)
AVI: Avi_5077
MDI: METDI5651
MEX: Mext_4599
MCH: Mchl_5060
CID: P73_2005
HNE: HNE_1255
SGI: SGRAN_3245(hsaB)
SPHU: SPPYR_0643
STAX: MC45_16625
SSY: SLG_03810
SPMI: K663_16395
SPHB: EP837_01489(hsaB)
SPHR: BSY17_1464
MTU: Rv3567c(hsaB)
MTC: MT3672
MRA: MRA_3606
MTUR: CFBS_3784
MTD: UDA_3567c
MTUB: MT7199_3630(hsaB)
MTUC: J113_24985
MTUE: J114_19080
MTUL: TBHG_03508
MTUT: HKBT1_3769
MTUU: HKBT2_3778
MBO: BQ2027_MB3598C(hsab)
MBB: BCG_3632c
MBT: JTY_3633
MBX: BCGT_3434
MAF: MAF_35800
MMIC: RN08_3944
MORY: MO_003726(hsaB)
MPA: MAP_0500
MAO: MAP4_3367
MAVI: RC58_16700
MAVU: RE97_16735
MAV: MAV_0594
MIT: OCO_05030
MIA: OCU_05070
MID: MIP_00945
MYO: OEM_05090
MIR: OCQ_05180
MLP: MLM_0738
MMAN: MMAN_47970
MUL: MUL_4138
MMI: MMAR_5062
MPSE: MPSD_52630
MSHO: MSHO_05460
MMC: Mmcs_4706
MKM: Mkms_4792
MJL: Mjls_5091
MMM: W7S_02455
MHAD: B586_04460
MSHG: MSG_04560(hsaB)
MSTO: MSTO_44630
MSIM: MSIM_29120
MSAK: MSAS_29140
MCOO: MCOO_27300
MBAI: MB901379_04451(hsaB_3)
MSEO: MSEO_34540
MBRD: MBRA_20020
MSHJ: MSHI_38550
MPHL: MPHLCCUG_00494(hsaB_1)
MVQ: MYVA_5215
MTHN: 4412656_04091(hsaB_2)
MHAS: MHAS_03776(hsaB_1)
MAUU: NCTC10437_02716(hsaB_3) NCTC10437_05066(hsaB_4)
MMAG: MMAD_48560
MMOR: MMOR_11770
MAIC: MAIC_05190
MARZ: MARA_47450
MGAD: MGAD_37670
MHEV: MHEL_27660
MSAR: MSAR_10960
MANY: MANY_33040
MAUB: MAUB_27080
MPOF: MPOR_53980
MPHU: MPHO_43390
MFLV: NCTC10271_00468(hsaB_1)
MCEE: MCEL_37750
MAB: MAB_0586
MABB: MASS_0555
MCHE: BB28_02795
MSTE: MSTE_00543
MSAL: DSM43276_00504(hsaB_1)
MTER: 4434518_03727(hsaB_2)
ASD: AS9A_0927
COA: DR71_752(hsaB)
CHAN: CHAN_12115(hsaB3)
NFR: ERS450000_03765(hsaB_2) ERS450000_05818(hsaB_3)
NAD: NCTC11293_01244(hsaB_2) NCTC11293_04400(hsaB_4)
RRT: 4535765_00585(hsaB_1) 4535765_00634(hsaB_2) 4535765_04041(hsaB_5)
RCR: NCTC10994_02086(hsaB_1) NCTC10994_02135(hsaB_2) NCTC10994_03280(hsaB_3)
GBR: Gbro_0922
GOR: KTR9_0822(hsaB) KTR9_4330
GRU: GCWB2_04185(hsaB1)
GOM: D7316_02453(hsaB_1) D7316_02571(hsaB_2)
SGR: SGR_3042
SGB: WQO_20525
SHY: SHJG_3986
SBH: SBI_06291
SVE: SVEN_4243
SALS: SLNWT_0921
STRE: GZL_05149
SLD: T261_4762
STRM: M444_15715
SPRI: SPRI_4256
SRW: TUE45_00680(hsaB_2) TUE45_04284(hsaB_4)
SLE: sle_01310(sle_01310) sle_62720(sle_62720)
STRD: NI25_18930
SLAU: SLA_4342
SALJ: SMD11_3928
SLX: SLAV_16820(hsaB1) SLAV_27190(hsaB2) SLAV_27445(hsaB3)
SGE: DWG14_00207(hsaB_1) DWG14_04767(hsaB_4)
SRJ: SRO_4177
SNF: JYK04_03901(hsaB)
SHUN: DWB77_04384(hsaB_1)
SCYG: S1361_17690(hsaB1)
SAUH: SU9_014410
SXT: KPP03845_102821(hsaB_2) KPP03845_103416(hsaB_3)
STPB: QR97_15115
SCT: SCAT_2368
ACH: Achl_1781
CCYC: SCMU_02120
MPH: MLP_43280
NCA: Noca_2773
NDK: I601_0582(hsaB_1) I601_3467(hsaB_2)
NAQU: ENKNEFLB_02531(hsaB)
NAL: B005_2517
TCU: Tcur_3523
SRO: Sros_2092
NCX: Nocox_09830(hsaB1)
TBI: Tbis_1628
FAL: FRAAL1664
GOB: Gobs_5034
MMAR: MODMU_5531
AMD: AMED_2525
AOI: AORI_2487
AJA: AJAP_26390(hsaB)
AMYY: YIM_14465(hsaB1)
AORI: SD37_13500
ACOR: LCL61_01260(hsaB)
PSEA: WY02_09245
PSEH: XF36_14940
AMI: Amir_4448
KAL: KALB_5121
MIL: ML5_6168
ACTN: L083_3831
ACTE: ACTI_41240
ATL: Athai_06800(mmyF)
CAI: Caci_8752
BALA: DSM104299_02798(hsaB)
CWO: Cwoe_2144
MTP: Mthe_0466
HASV: SVXHr_2401
 » show all
Reference
  Authors
Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD
  Title
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
  Journal
J Biol Chem 285:22264-75 (2010)
DOI:10.1074/jbc.M109.099028
  Sequence
[mtu:Rv3567c]
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

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