KEGG ORTHOLOGY: K16050

ORTHOLOGY: K16050

Entry

K16050                      KO

Symbol

hsaD

Name

4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17]

Pathway

map00984

Steroid degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Reaction

R09883

4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.17  4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
     K16050  hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

Other DBs

COG:

COG0596

Genes

RGL:	CS053_01755

VAF:	D1115_22495

PRE:	PCA10_13810

PFUW:

KF707C_12160

PPUT:

L483_14175

PPUN:

PP4_27040(mhpC)

PVR:	PverR02_11710

PPUU:

PputUW4_01659(mhpC)

PKC:

PKB_4240

PFZ:	AV641_10660

PLQ:	AA042_19905

PPSY:

AOC04_07965

PSET:

THL1_1432

PSIL:

PMA3_11770

PKE:	DLD99_14450 DLD99_14755

PUM:	HGP31_20725

PPSH:

PLAL:

PSEP:

PMUY:

PAZE:

PTAE:

NCTC10697_02081(mhpC)

PCAV:

D3880_08220 D3880_17375

PPHN:

HU825_14570

PIZ:	LAB08_R40980

PFIT:

KJY40_13695

PKM:	PZ739_11655

PTRL:

PSHS:

PLAU:

PFOU:

PBEJ:

SDEG:

HARR:

PPHA:

KAK:	Kalk_07850

ASEI:

I8T81_09205

ACUM:

C9E88_011925

ADS:	FPL17_05420

ATN:	FM020_06325

SPL:

SHL:

COLW:

CBER:

PHA:	PSHAa0893(tesD)

PTN:	PTRA_a1026(hsaD)

PNG:	PNIG_a1077(hsaD)

SNAN:

I6N98_01455 I6N98_10805

ZAL:	AZF00_11435

HJA:	BST95_09500

HALC:

AFUS:

PAQM:

MSEC:

MRZ:	KDW95_01070

EMP:	EZMO1_1316(tesD)

SOK:	D0B54_04210 D0B54_06205

SINI:

GT972_14675

FCE:	JN531_005825

GBI:	PG2T_02180

GPB:	HDN1F_27100(tesD)

RIN:	ACS15_4349

REH:	H16_B0600(bphD)

CNC:	CNE_2c05450(fabG2)

CUH:	BJN34_30955

REU:	Reut_A1513

CTI:	RALTA_B0404(mhpC)

CBW:	RR42_s2308

COX:	E0W60_08040

CUK:	KB879_20440

BHG:	I6G56_07560

BUD:	AQ610_12660

BUR:	Bcep18194_B1463

BCJ:

BCEN:

BCEO:

BCT:

BCED:

BCEP:

BPYR:

BCON:

BDF:	WI26_21125

BTEI:

WS51_05675

BPSL:

WS57_06065

BMEC:

WJ16_19990 WJ16_26770

BSTL:

BBJ41_21320 BBJ41_34095

BANN:

JFN94_25630

BARI:

NLX30_30205 NLX30_35010

BAEN:

L3V59_21720

BUL:	BW21_2676(hsaD)

BPLA:

BURK:

BPH:

BFN:

PBRY:

PPAI:

PVE:	UC34_07060

PFIB:

PI93_021410

CABA:

SBC2_49060(mhpC)

BGV:	CAL12_23370

CTT:	CtCNB1_1354

CTES:

O987_07745

CRJ:	QMY55_07025

DIH:	G7047_09710

SMIO:

CATMQ487_29910(mhpC)

AZD:	CDA09_09460

THU:	AC731_008590

THAU:

C4PIVTH_4256

THAG:

CKCBHOJB_02331(mhpC)

CAUL:

KCG34_11045

CON:	TQ29_16150

PALX:

GQA70_21455

NAR:

Saro_3690

NPP:	PP1Y_Mpl3096

NOV:	TQ38_027285

NOT:	C7W88_20930

SWI:	Swit_1754 Swit_1827 Swit_3338 Swit_4183

SPHD:

HY78_08860 HY78_16445 HY78_16815

RDI:	CMV14_03930 CMV14_16820

SSAN:

SPAN:

SPKC:

SPHA:

SLAN:

SBIN:

SNAP:

SPHB:

EP837_03392(hsaD)

PHAO:

HF685_05525

PHZ:	CHX26_05310

NTD:	EGO55_04995 EGO55_13685

CAEN:

K5X80_14730

SEDD:

ERJ70_09520

AACO:

K1I37_05675

MTU:	Rv3569c(hsaD)

MTV:	RVBD_3569c

MTC:	MT3674(bphD)

MRA:	MRA_3608(bphD)

MTF:	TBFG_13602

MTB:	TBMG_03608

MTK:	TBSG_03635

MTZ:	TBXG_003583

MTG:	MRGA327_22035

MTI:	MRGA423_22555

MTE:	CCDC5079_3310

MTUR:

CFBS_3786(bphD)

MTL:	CCDC5180_3262

MTO:	MTCTRI2_3634(bphD)

MTD:	UDA_3569c(bphD)

MTN:	ERDMAN_3916(bphD)

MTJ:	J112_19220

MTUB:

MT7199_3632

MTUC:

J113_24995

MTUE:

J114_19090

MTX:	M943_18355

MTUH:

I917_25075

MTUL:

TBHG_03510

MTUT:

HKBT1_3771(bphD)

MTUU:

HKBT2_3780(bphD)

MTQ:	HKBS1_3783(bphD)

MBO:	BQ2027_MB3600C(hsad)

MBB:	BCG_3634c(bphD)

MBT:	JTY_3635(bphD)

MBM:	BCGMEX_3632c(bphD)

MBK:	K60_037070

MBX:

BCGT_3436

MAF:	MAF_35820(bphD)

MMIC:

RN08_3946

MCE:	MCAN_35821(bphD)

MCQ:	BN44_110064(bphD)

MCV:	BN43_90070(bphD)

MCX:	BN42_90067(bphD)

MCZ:	BN45_100083(bphD)

MORY:

MPA:

MAO:

MAVI:

MAVU:

MAV:	MAV_0592 MAV_2517

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MMAN_47950(bphD)

MSER:

MTY59_24290(bphD)

MSA:	Mycsm_01915 Mycsm_01992 Mycsm_05839

MUL:	MUL_4140(bphD)

MMI:	MMAR_1502 MMAR_5064(bphD)

MMAE:

MMARE11_14020 MMARE11_48790(bphD)

MLI:	MULP_01620 MULP_05322(bphD)

MPSE:

MPSD_43530 MPSD_52650(hsaD)

MSHO:

MSHO_05480(bphD) MSHO_21750

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_12125 MKAN_22320

MYV:	G155_26480

MYE:	AB431_09620

MHAD:

B586_04450

MDX:	BTO20_04380 BTO20_24345

MSHG:

MSG_03543 MSG_04562(hsaD)

MFJ:	MFLOJ_40660(hsaD)

MSTO:

MSTO_44610(hsaD) MSTO_55690

MSIM:

MSIM_29100(hsaD)

MSAK:

MSAS_13430 MSAS_29160(hsaD)

MKU:	I2456_25680

MLW:	MJO58_19440 MJO58_25095

MXE:	MYXE_05070(bphD)

MNV:	MNVI_12520(bphD)

MPAG:

C0J29_01145 C0J29_27830

MGOR:

H0P51_01140 H0P51_25870

MCOO:

MCOO_27320(bphD) MCOO_46610(mhpC_3)

MBAI:

MB901379_04453(hsaD_3)

MSEO:

MSEO_27510 MSEO_34560(bphD)

MHEK:

JMUB5695_00468(bphD)

MGAU:

MGALJ_07320 MGALJ_38570

MLJ:	MLAC_47230(bphD)

MBRD:

MBRA_01310 MBRA_20000(hsaD)

MSHJ:

MSHI_38530(hsaD)

MMAM:

K3U93_22690

MSPG:

F6B93_20490

MOT:	LTS72_27915

MPAA:

MKK62_02390 MKK62_17500

MKY:	IWGMT90018_57500(bphD)

MADI:

A7U43_06660 A7U43_08590

MWU:	PT015_00105 PT015_15565

MYW:	BVC93_09280

MSM:	MSMEG_6037

MSG:	MSMEI_5876(bphD)

MSB:	LJ00_29845

MSN:	LI99_29850

MSH:	LI98_29855

MVA:	Mvan_0592 Mvan_5307

MGI:

Mflv_1464

MSP:	Mspyr1_47030

MCB:	Mycch_4674

MNE:	D174_24705

MYN:	MyAD_24240

MFT:	XA26_21680 XA26_53620

MPHL:

MPHLCCUG_00492(hsaD_1)

MVQ:

MYVA_5217

MLL:	B1R94_19690 B1R94_25465

MRH:	MycrhN_2244

MTHN:

4412656_04093(hsaD_3)

MHAS:

MHAS_03778(hsaD_5)

MDU:	MDUV_49000

MCHT:

MCHIJ_19300

MAUU:

NCTC10437_05068(hsaD_3)

MMAG:

MMAD_48580

MMOR:

MMOR_11750

MFX:	MFAL_03550(mhpC) MFAL_32590

MAIC:

MAIC_16360

MIJ:	MINS_00700

MALV:

MALV_42130

MTY:	MTOK_21990

MPSC:

MPSYJ_15760

MARZ:

MARA_47430

MGAD:

MGAD_37690

MHEV:

MHEL_27640 MHEL_40900

MSAR:

MSAR_10980

MANY:

MANY_02510(mhpC)

MAUB:

MAUB_47460(hsaD)

MPOF:

MPOR_54000

MPHU:

MPHO_21610 MPHO_43370

MMUC:

C1S78_007415 C1S78_025615

MMAT:

MMAGJ_33770

MBOK:

MBOE_04970 MBOE_53390

MFG:	K6L26_05340

MSEI:

MSEDJ_02520

MFLV:

NCTC10271_00466(hsaD_1)

MCEE:

MCEL_37730

MMON:

EWR22_25465

MGO:	AFA91_10585

MHOL:

K3U96_03075

MSEN:

K3U95_25515

MPAE:

K0O64_09000

MRF:	MJO55_02070 MJO55_24180

MDF:	K0O62_25970

MCRO:

MI149_09950

MGRO:

FZ046_02945

MAUS:

JN090_01850 JN090_26585

MIZ:	BAB75_13835

MJD:	JDM601_1132

MMIN:

MMIN_05410(mhpC_1)

MHER:

K3U94_06260

MVM:	MJO54_06430

ASD:	AS9A_0925(mhpC)

COK:	COCCU_00295(hsaD1)

NFA:

NFA_4730

NFR:	ERS450000_03763(hsaD_1)

NCY:	NOCYR_0502

NBR:	O3I_002670

NNO:	NONO_c05020(hsaD) NONO_c29060 NONO_c37010

NSL:	BOX37_02180

NSR:	NS506_01261(hsaD) NS506_06808

NTP:	CRH09_03310

NOZ:	DMB37_23595

NOD:	FOH10_28740

NAH:	F5544_02635

NAD:	NCTC11293_01246(hsaD_2) NCTC11293_04256(hsaD_4)

NWL:	NWFMUON74_04940

NIE:	KV110_03030

NTC:	KHQ06_35200

NHU:	H0264_03855

NYA:	LTV02_28885 LTV02_38600

NGP:	LTT66_00665 LTT66_14745 LTT66_15425

NSPU:

IFM12276_01690 IFM12276_39830

NYU:	D7D52_04500 D7D52_09565

RHA:	RHA1_ro04540(hsaD)

RER:

RER_07560

REY:

O5Y_03675

REB:	XU06_03915

RQI:	C1M55_04155

ROP:

ROP_44550

ROA:	Pd630_LPD00992

RPY:	Y013_19030

RBY:	CEJ39_05395

RAV:	AAT18_03970 AAT18_26195

RHW:	BFN03_15195

RRZ:	CS378_19610

RHQ:	IM25_08880

RHOD:

AOT96_14550

RRT:	4535765_00583(hsaD_1) 4535765_04568(hsaD_4)

RCR:	NCTC10994_02137(hsaD_2)

RTM:	G4H71_07390

RKO:	JWS14_24490

RGO:	KYT97_23240

ROZ:	CBI38_04175

RPSK:

JWS13_20435

RGOR:

NMQ04_02520 NMQ04_22045 NMQ04_22210

RHOP:

D8W71_26910

RHOO:

RA302_04025

RHOU:

KZJ41_03965 KZJ41_22865 KZJ41_27645

RHOW:

A4U64_20805 A4U64_25020

REQ:	REQ_01450 REQ_06810 REQ_35100

PDEF:

P9209_02565 P9209_05880 P9209_29070

GOJ:	GR168_23130

GAM:	GII34_11030 GII34_18525

GPD:	GII33_04205 GII33_08475 GII33_16055

GMG:	NWF22_15540

SPIN:

KV203_17345 KV203_17540

TPR:

Tpau_3844

TSM:	ASU32_13590 ASU32_21900

TPUL:

TPB0596_41850 TPB0596_45490

TSD:	MTP03_43290

DTM:	BJL86_2839 BJL86_3316

DIT:	C3V38_06170

DIZ:	CT688_16945

DPC:	A6048_17575

DLU:	A6035_16880

DKN:	NHB83_17160

TOY:	FO059_01795

SCYE:

R2B67_01940

SMAL:

SMALA_0968 SMALA_1212

SSOI:

I1A49_08330 I1A49_09545

SDV:	BN159_8214

SVT:	SVTN_35910

SLC:	SL103_24910

STSI:

A4E84_36410

SGM:	GCM10017557_80450(mhpC)

SALU:

DC74_7446

SALL:

SAZ_38435

SAUO:

BV401_08635 BV401_09835

SALF:

SMD44_02218(hsaD)

SLX:	SLAV_27435(hsaD)

SAQU:

EJC51_46900

SPHV:

F9278_45575

SCHA:

CP983_10625

SGX:	H4W23_38545

SSPB:

CP982_11900

SNF:	JYK04_02662(hsaD)

SVD:	CP969_28370

SPRA:

CP972_28850

SXN:	IAG42_26650

SLF:	JEQ17_44910

SDEC:

L3078_04210 L3078_31100

SAOV:

G3H79_28030

STAA:

LDH80_36405

SNIG:

HEK616_31470(mhpC)

SCIR:

STRCI_000454

SLON:

LGI35_13840

SKG:	KJK29_37290

SFP:	QUY26_30060

YIA:	LO772_04905

MIO:	AOA12_18570

SALD:

FVA74_01355

ASUF:

MNQ99_15000

JTE:	ASJ30_14570

NCA:

Noca_2775

NDK:	I601_3469(hsaD_2)

NBE:	Back2_27210(mhpC_1)

NANO:

G5V58_09765

NARO:

CFH99_13525

NPI:	G7071_04055 G7071_15940

NPC:	KUV85_04285

NMAR:

HPC71_01600 HPC71_09520

NFC:	KG111_01290 KG111_05690 KG111_08320

NBI:	SHK19_12520

PSIM:

KR76_14475

AEB:	C6I20_03265

AWN:	NQV15_16590

AMAZ:

LUW76_09950 LUW76_09965 LUW76_45470

ACIR:

OG979_00780

ACTQ:

OG417_51275

NFS:	OIE67_46760

FRI:	FraEuI1c_4100

AMD:	AMED_2523(mhpC) AMED_7185

AMN:	RAM_12825 RAM_36905

AMM:	AMES_2495(mhpC) AMES_7076

AMZ:	B737_2496(mhpC) B737_7076

AOI:	AORI_2485(mhpC)

AJA:	AJAP_26400(hsaD)

AMQ:	AMETH_4837(mhpC)

AMYC:

CU254_10465

AMYB:

BKN51_05025

AAB:	A4R43_16040

AMYY:

YIM_14455(hsaD1)

AORI:

SD37_13490

AACD:

LWP59_08655 LWP59_29195

APRT:

MUY14_23825

AROO:

NQK81_09925

ATHM:

L1857_26960

ARHD:

VSH64_01785 VSH64_09275

AMOG:

QRX60_26345

ACYN:

ORV05_07255 ORV05_08280

ACOR:

LCL61_01250(hsaD)

PBRO:

HOP40_22535

PPEL:

H6H00_19080

KAL:

KALB_5123

KUT:	JJ691_08340(mhpC_1) JJ691_37190(mhpC_2)

KPHY:

AOZ06_42785

LED:	BBK82_38920

ALO:

PMAD:

SACE:

CROS:

STP:	Strop_2670

SAQ:

Sare_2878

MCRA:

ID554_07075

VER:	HUT12_12175

AMS:	AMIS_19190

AIH:	Aiant_18880(mhpC)

ACTL:

L3i22_084460(mhpC)

ASIC:

Q0Z83_065580

AOU:	ACTOB_004120

ACTE:

ACTI_41220(mhpC)

AFS:

AFR_13045

DFU:	Dfulv_33635

LMAJ:

GKN94_12655

» show all

Reference

PMID:19875455

Authors

Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD

Title

Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.

Journal

J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081

Sequence

[mtu:Rv3569c]

Reference

PMID:21924910

Authors

Ouellet H, Johnston JB, de Montellano PR

Title

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Journal

Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

All links

Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1671)   
   KEGG GENES (545)   
   KEGG MGENES (973)   
   RefGene (147)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (1688)   

Download RDF

DBGET integrated database retrieval system