KEGG   ORTHOLOGY: K16173
Entry
K16173                      KO                                     

Name
acd
Definition
glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
Pathway
ko00362  Benzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16173  acd; glutaryl-CoA dehydrogenase (non-decarboxylating)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.32  glutaryl-CoA dehydrogenase (acceptor)
     K16173  acd; glutaryl-CoA dehydrogenase (non-decarboxylating)
Other DBs
RN: R05579
Genes
TIG: THII_2206
GBI: PG2T_13310
BFN: OI25_7305
GBM: Gbem_1452
GEO: Geob_0237
GEM: GM21_2801
DML: Dmul_25030(acdA5) Dmul_34900(acdA13)
DAL: Dalk_0058
DAT: HRM2_38550(acd11) HRM2_38670(acd12)
DTO: TOL2_C38270(acdA5)
DOV: DSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)
DWD: DSCW_66360(acdB)
DALK: DSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830
HOH: Hoch_1175
SAT: SYN_00480
DBR: Deba_2447
BMYC: DJ92_4005
BAG: Bcoa_0791
OIH: OB0864
GKA: GK0445
GTN: GTNG_0452
GEA: GARCT_00480(acdA_1)
AFL: Aflv_1240(acdA)
LSP: Bsph_0858
HLI: HLI_20160
VPN: A21D_02347(acdA_3)
PSYO: PB01_02630
ASOC: CB4_03627(acdA_4)
AAC: Aaci_1850
AAD: TC41_1948(acd)
BTS: Btus_0350
SIV: SSIL_3577
CHY: CHY_1737
LPIL: LIP_0806
HHG: XM38_019870(anaB_1)
RCA: Rcas_3165
CAG: Cagg_0741
HAU: Haur_1248
TRO: trd_0039
PBF: CFX0092_A0325(acdA)
TTR: Tter_0362
ABAC: LuPra_03850(acdA_2)
MOX: DAMO_3029(acdA)
AG: ACP50614(acd)
 » show all
Reference
  Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
  Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.
  Journal
J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09
  Sequence

KEGG   ENZYME: 1.3.99.32
Entry
EC 1.3.99.32                Enzyme                                 

Name
glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
Reaction(IUBMB)
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN:R05579]
Reaction(KEGG)
R05579
Substrate
glutaryl-CoA [CPD:C00527];
acceptor [CPD:C00028]
Product
(E)-glutaconyl-CoA [CPD:C02411];
reduced acceptor [CPD:C00030]
Comment
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
History
EC 1.3.99.32 created 2012, modified 2013
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating)
Genes
TIG: THII_2206
GBI: PG2T_13310
BFN: OI25_7305
GBM: Gbem_1452
GEO: Geob_0237
GEM: GM21_2801
DML: Dmul_25030(acdA5) Dmul_34900(acdA13)
DAL: Dalk_0058
DAT: HRM2_38550(acd11) HRM2_38670(acd12)
DTO: TOL2_C38270(acdA5)
DOV: DSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)
DWD: DSCW_66360(acdB)
DALK: DSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830
HOH: Hoch_1175
SAT: SYN_00480
DBR: Deba_2447
BMYC: DJ92_4005
BAG: Bcoa_0791
OIH: OB0864
GKA: GK0445
GTN: GTNG_0452
GEA: GARCT_00480(acdA_1)
AFL: Aflv_1240(acdA)
LSP: Bsph_0858
HLI: HLI_20160
VPN: A21D_02347(acdA_3)
PSYO: PB01_02630
ASOC: CB4_03627(acdA_4)
AAC: Aaci_1850
AAD: TC41_1948(acd)
BTS: Btus_0350
SIV: SSIL_3577
CHY: CHY_1737
LPIL: LIP_0806
HHG: XM38_019870(anaB_1)
RCA: Rcas_3165
CAG: Cagg_0741
HAU: Haur_1248
TRO: trd_0039
PBF: CFX0092_A0325(acdA)
TTR: Tter_0362
ABAC: LuPra_03850(acdA_2)
MOX: DAMO_3029(acdA)
 » show all
Reference
1  [PMID:19395484]
  Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
  Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the  aromatic metabolism of obligately anaerobic bacteria.
  Journal
J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09
  Sequence
Reference
2  [PMID:20486657]
  Authors
Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U
  Title
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
  Journal
Biochemistry 49:5350-7 (2010)
DOI:10.1021/bi100317m
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.32
IUBMB Enzyme Nomenclature: 1.3.99.32
ExPASy - ENZYME nomenclature database: 1.3.99.32
BRENDA, the Enzyme Database: 1.3.99.32

KEGG   REACTION: R05579
Entry
R05579                      Reaction                               

Name
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (non-decarboxylating)
Definition
Glutaryl-CoA + Acceptor <=> Glutaconyl-1-CoA + Reduced acceptor
Equation
Reaction class
RC00052  C00527_C02411
Enzyme
Pathway
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
Other DBs
RHEA: 47423

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