KEGG ORTHOLOGY: K16184

ORTHOLOGY: K16184

Entry

K16184                      KO

Symbol

AKT1S1, PRAS40

Name

proline-rich AKT1 substrate 1

Pathway

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04714

Thermogenesis

map05131

Shigellosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
   04150 mTOR signaling pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
   04213 Longevity regulating pathway - multiple species
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
Membrane trafficking [BR:ko04131]
Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1

Genes

HSA:	84335(AKT1S1)

PTR:	456218(AKT1S1)

PPS:	100981524(AKT1S1)

GGO:	101151809(AKT1S1)

PON:	100449244(AKT1S1)

PPYG:

129020477(AKT1S1)

NLE:	100606336(AKT1S1)

HMH:	116478173(AKT1S1)

SSYN:

129460520(AKT1S1)

MCC:	719101(AKT1S1)

MCF:	102139860(AKT1S1)

MTHB:

126943131

MNI:	105497176(AKT1S1)

CSAB:

103235060(AKT1S1)

CATY:

105595312(AKT1S1)

PANU:

101022446(AKT1S1)

TGE:	112612631(AKT1S1)

MLEU:

105528967(AKT1S1)

RRO:	104667216(AKT1S1)

RBB:	108535813(AKT1S1)

TFN:	117091606(AKT1S1)

PTEH:

111519922(AKT1S1)

CANG:

105514750(AKT1S1)

CJC:	100385926(AKT1S1)

SBQ:	101035426(AKT1S1)

CIMI:

108292019(AKT1S1)

ANAN:

105723240(AKT1S1)

CSYR:

103258093(AKT1S1)

MMUR:

105865626(AKT1S1)

LCAT:

123623799(AKT1S1)

PCOQ:

105809369(AKT1S1)

OGA:	100944265(AKT1S1)

MMU:	67605(Akt1s1)

MCAL:

110299208(Akt1s1)

MPAH:

110324411(Akt1s1)

RNO:	292887(Akt1s1)

MCOC:

116102150(Akt1s1)

ANU:	117703636(Akt1s1)

MUN:	110546783(Akt1s1)

CGE:	100768286(Akt1s1)

MAUA:

101831090(Akt1s1)

PROB:

127213931(Akt1s1)

PLEU:

114684368(Akt1s1)

MORG:

121452091(Akt1s1)

MFOT:

126488194

AAMP:

119802583(Akt1s1)

NGI:	103743684(Akt1s1)

HGL:	101712955(Akt1s1)

CPOC:

100722328(Akt1s1)

CCAN:

109683918(Akt1s1)

DORD:

105994280(Akt1s1)

DSP:	122125705(Akt1s1)

PLOP:

125338594(Akt1s1)

NCAR:

124967127

MMMA:

107151227(Akt1s1)

OCU:

127489858

OPI:	101519220(AKT1S1)

TUP:	102485528(AKT1S1)

GVR:	103606300 103607895

CFA:	610130(AKT1S1)

CLUD:

112645125(AKT1S1)

VVP:	112931404(AKT1S1)

VLG:	121484108(AKT1S1)

NPO:	129499961(AKT1S1)

AML:	109489401(AKT1S1)

UMR:	103657265(AKT1S1)

UAH:	113243278(AKT1S1)

UAR:	123776313(AKT1S1)

ELK:

111160809

LLV:

125089749

MPUF:

101683323(AKT1S1)

MNP:	132006125(AKT1S1)

MLK:	131818026(AKT1S1)

NVS:	122911802(AKT1S1)

ORO:	101366130(AKT1S1)

EJU:	114199635(AKT1S1)

ZCA:	113935934(AKT1S1)

MLX:	117998320(AKT1S1)

NSU:	110577702(AKT1S1)

LWW:	102751206(AKT1S1)

FCA:	101100932(AKT1S1)

PYU:	121018803(AKT1S1)

PCOO:

112850817(AKT1S1)

PBG:	122493845(AKT1S1)

PVIV:

125153672(AKT1S1)

LRUF:

124510892

PPAD:

109253038(AKT1S1)

PUC:

125915937

AJU:

106983118

HHV:	120240444(AKT1S1)

BTA:	514859(AKT1S1)

BOM:	102264796(AKT1S1)

BIU:	109572134(AKT1S1)

BBUB:

102395301(AKT1S1)

BBIS:

104995737(AKT1S1)

CHX:	102186333(AKT1S1)

OAS:	101109114(AKT1S1)

BTAX:

128063236(AKT1S1)

ODA:	120872112(AKT1S1)

CCAD:

122420257(AKT1S1)

MBEZ:

129546527(AKT1S1)

SSC:	100519715(AKT1S1)

CFR:	102515969(AKT1S1)

CBAI:

105062650(AKT1S1)

CDK:	105100186(AKT1S1)

VPC:	102525299(AKT1S1)

BACU:

103005941(AKT1S1)

BMUS:

118885041(AKT1S1)

LVE:	103075856(AKT1S1)

OOR:	101289949(AKT1S1)

DLE:	111180592(AKT1S1)

PCAD:

102990917(AKT1S1)

PSIU:

116744320(AKT1S1)

NASI:

112415646(AKT1S1)

ECB:	100052282(AKT1S1)

EPZ:	103558294(AKT1S1)

EAI:	106824154(AKT1S1)

MYB:	102243802(AKT1S1)

MYD:	102758931(AKT1S1)

MMYO:

118655365(AKT1S1)

MLF:	102424796(AKT1S1)

MDT:	132216220(AKT1S1)

PKL:	118712213(AKT1S1)

EFUS:

103297615(AKT1S1)

MNA:	107531871(AKT1S1)

DRO:	112310069(AKT1S1)

AJM:	119050615(AKT1S1) 119059915

PDIC:

114511038(AKT1S1)

PHAS:

123830191(AKT1S1)

MMF:	118638271(AKT1S1)

PPAM:

129082947(AKT1S1)

HAI:	109391032(AKT1S1)

RFQ:	117034482(AKT1S1)

PALE:

102897877(AKT1S1)

PGIG:

120615527(AKT1S1)

PVP:	105301726(AKT1S1)

RAY:	107498836(AKT1S1)

MJV:	108383352(AKT1S1)

TOD:	119249606(AKT1S1)

SARA:

101549680(AKT1S1)

SETR:

126027823(AKT1S1)

LAV:	100671446(AKT1S1)

TMU:

101345300

ETF:	101659227(AKT1S1)

MDO:	100030158(AKT1S1)

GAS:	123239820(AKT1S1)

SHR:	100928550(AKT1S1)

AFZ:

127556600

PCW:	110219791(AKT1S1)

TVP:	118838883(AKT1S1)

OAA:	114814792(AKT1S1)

ASN:	102367984(AKT1S1)

AMJ:	102558199(AKT1S1)

CCAY:

125628024(AKT1S1)

CPIC:

101938133(AKT1S1)

MRV:

120388482

ACS:	100557925(akt1s1)

ASAO:

132777947(AKT1S1)

PVT:	110078574(AKT1S1)

SUND:

121934262(AKT1S1)

PBI:	103049186(AKT1S1)

PMUR:

107282550 107298507

CTIG:

120304547(AKT1S1)

TSR:	106549271(AKT1S1) 106556088

PGUT:

117669131(AKT1S1)

APRI:

131197295(AKT1S1)

PTEX:

113443697(AKT1S1) 113450730

NSS:	113418557(AKT1S1)

VKO:	123032322(AKT1S1)

PMUA:

114608013(AKT1S1)

PRAF:

128399253(AKT1S1)

ZVI:	118094468(AKT1S1)

HCG:	128331712(AKT1S1)

GJA:	107116605(AKT1S1)

STOW:

125445341(AKT1S1)

EMC:	129338179(AKT1S1)

XLA:	431814(akt1s1.S) 495075(akt1s1.L)

XTR:	496515(akt1s1)

NPR:	108792627(AKT1S1)

RTEM:

120916512(AKT1S1)

BBUF:

121002400(AKT1S1)

BGAR:

122926678(AKT1S1)

MUO:	115466625(AKT1S1)

GSH:	117367815(AKT1S1)

DRE:	566559(akt1s1)

SRX:	107729505 107732888

SANH:

107680841 107687628

SGH:	107551160 107564011 107577586

CCAR:

109109154

CAUA:

113046632 113047030

CGIB:

127949116 127953665

PTET:

122339317(akt1s1)

LROH:

127163174(akt1s1)

OMC:	131537026(akt1s1)

PPRM:

120489305(akt1s1)

RKG:	130078619(akt1s1)

MAMB:

125276446(akt1s1)

CIDE:

127509144

CERY:

137017558(akt1s1)

MASI:

127449935 127451387

TROS:

130562161(akt1s1)

TDW:	130426981(akt1s1)

MANU:

129436134(akt1s1)

IPU:

108280807

IFU:	128603782(akt1s1)

PHYP:

113528230(akt1s1)

SMEO:

124397309(akt1s1)

TFD:	113663912(akt1s1)

TVC:	132860640(akt1s1)

TRN:	134300256(akt1s1)

AMEX:

111193360(akt1s1)

CMAO:

118820924(akt1s1)

EEE:	113587138(akt1s1)

CHAR:

105897692(akt1s1)

TRU:	101067319 115248108

TFS:	130515104(akt1s1)

TNG:	GSTEN00000150G001 GSTEN00011661G001

LCO:	104939070(akt1s1)

NCC:	104954396(akt1s1)

TBEN:

117492409(akt1s1)

CGOB:

115012654(akt1s1)

PGEO:

117451212(akt1s1)

GACU:

117548771(akt1s1)

EMAC:

134878007(akt1s1)

ELY:	117268340(akt1s1)

EFO:	125880066(akt1s1)

PLEP:

121957065(akt1s1)

SLUC:

116063717(akt1s1)

ECRA:

117957591(akt1s1)

ESP:	116703126(akt1s1)

PFLV:

114570346(akt1s1)

GAT:	120827382(akt1s1)

PPUG:

119220047(akt1s1)

AFB:	129098640(akt1s1)

CLUM:

117735505(akt1s1)

PSWI:

130188581(akt1s1)

MSAM:

119894016(akt1s1)

SCHU:

122868740(akt1s1)

CUD:	121529436(akt1s1)

ALAT:

119014234(akt1s1)

MZE:	101481934(akt1s1)

ONL:	100689736(akt1s1)

OAU:	116328999(akt1s1)

OLA:	101169289(akt1s1)

OML:	112146580(akt1s1)

CSAI:

133421507(akt1s1)

XMA:	102221079(akt1s1)

XCO:	114159983(akt1s1)

XHE:	116735590(akt1s1)

PRET:

103468981(akt1s1)

PFOR:

103144946(akt1s1)

PLAI:

106965250(akt1s1)

PMEI:

106921176(akt1s1)

GAF:	122822606(akt1s1)

PPRL:

129373933(akt1s1)

CVG:	107097127(akt1s1)

CTUL:

119791295(akt1s1)

GMU:	124863471 124864830

NFU:	107378483(akt1s1)

KMR:	108237767(akt1s1)

ALIM:

106524812 106536245

NWH:	119421847(akt1s1)

AOCE:

111572742(akt1s1)

MCEP:

124997632(akt1s1)

CSEM:

103392853(akt1s1)

POV:	109634335(akt1s1)

SSEN:

122785717(akt1s1)

HHIP:

117766445(akt1s1)

HSP:	118123203(akt1s1)

PPLT:

128458038(akt1s1)

SMAU:

118288635(akt1s1)

LCF:

108880633

SDU:	111217583(akt1s1)

SLAL:

111660518(akt1s1)

XGL:	120787846(akt1s1)

HCQ:	109527791(akt1s1)

SSCV:

125983784

SBIA:

133514039(akt1s1)

PEE:	133415320(akt1s1)

PTAO:

133465513(akt1s1)

BPEC:

110161314(akt1s1)

MALB:

109963177(akt1s1)

BSPL:

114860564(akt1s1)

SJO:	128378941(akt1s1)

SASA:

100380484(akts1) 106597455 106601514 106601546 106606916(akt1s1)

STRU:

115171487 115203079

OTW:	112258995(akt1s1)

OMY:	110486650 110538608

OGO:	123998982 124015293

ONE:	115110742 115118542

OKI:	109883675 109898717

OKE:	118377081 118384726

SALP:

112073326 112077631

SNH:	120034221 120040292

CCLU:

121568930 121568968

ELS:	105012938(akt1s1)

SFM:	108941800(akt1s1)

PKI:	111836870(akt1s1)

AANG:

118216957(akt1s1)

LOC:	102683567(akt1s1)

PSPA:

121306008(akt1s1)

ARUT:

117421660 117966751

PSEX:

120542348(akt1s1)

LCM:	102354837(AKT1S1)

CMK:	103173667(akt1s1)

RTP:	109923030(akt1s1)

CPLA:

122542135(akt1s1)

HOC:	132831358(akt1s1)

LERI:

129713905(akt1s1)

PMRN:

116939856(AKT1S1)

LRJ:	133350364(AKT1S1)

BFO:

118412296

BBEL:

109468757

CIN:

100176540

SPU:	100891962 105436529

APLC:

ARUN:

SKO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

ACEP:

PBAR:

HST:

DQU:

CFO:

LHU:	105673603(PRAS40)

PGC:

109853289

VVE:

124947108

NVI:	100217361(Lobe)

CSOL:

CCIN:

NVL:

CLEC:

NLU:

PHU:	Phum_PHUM138270

BROR:

PCHN:

PCLA:

PTRU:

MNZ:

PPOI:

DSV:

RSAN:

VDE:

VJA:

TUT:

CSCU:

CVS:	136976506 136977988

PTEP:

107444734

ABRU:

129961096

SDM:

118200099

LGI:	LOTGIDRAFT_231573

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

MAEA:

OBI:

OSN:

LJP:

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_63504

» show all

Reference

PMID:17386266

Authors

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM

Title

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Journal

Mol Cell 25:903-15 (2007)
DOI:10.1016/j.molcel.2007.03.003

Reference

PMID:12524439

Authors

Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA

Title

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.

Journal

J Biol Chem 278:10189-94 (2003)
DOI:10.1074/jbc.M210837200

Sequence

[hsa:84335]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Gene (504)   
   KEGG GENES (428)   
   KEGG MGENES (27)   
   RefGene (47)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (522)   

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