KEGG   ORTHOLOGY: K16269
Entry
K16269            Tight     KO                                     

Name
todD, tcbB
Definition
cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]
Pathway
ko00361  Chlorocyclohexane and chlorobenzene degradation
ko00362  Benzoate degradation
ko00623  Toluene degradation
ko00624  Polycyclic aromatic hydrocarbon degradation
ko00643  Styrene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00623 Toluene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00643 Styrene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00624 Polycyclic aromatic hydrocarbon degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.19  cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
    1.3.1.119  chlorobenzene dihydrodiol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Other DBs
RN: R00812 R04088 R05354 R05397 R06832 R06857 R07703
COG: COG1028
GO: 0018504 0018501
Genes
PPF: Pput_2877
PPX: T1E_4270(tobD)
PMON: X969_10950
PMOT: X970_10605
BPT: Bpet3742(hcaB)
AG: AAC43636(tcbB)
Reference
PMID:2670929
  Authors
Zylstra GJ, Gibson DT
  Title
Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli.
  Journal
J Biol Chem 264:14940-6 (1989)
  Sequence
[ppf:Pput_2877]
Reference
PMID:8626733
  Authors
Werlen C, Kohler HP, van der Meer JR
  Title
The broad substrate chlorobenzene dioxygenase and cis-chlorobenzene dihydrodiol dehydrogenase of Pseudomonas sp. strain P51 are linked evolutionarily to the enzymes for benzene and toluene degradation.
  Journal
J Biol Chem 271:4009-16 (1996)
DOI:10.1074/jbc.271.8.4009
  Sequence

KEGG   ENZYME: 1.3.1.19
Entry
EC 1.3.1.19                 Enzyme                                 

Name
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase;
cis-benzene glycol dehydrogenase;
cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+ [RN:R00812]
Reaction(KEGG)
R00812;
(other) R04088 R05354 R07703
Substrate
cis-1,2-dihydrobenzene-1,2-diol [CPD:C04091];
NAD+ [CPD:C00003]
Product
catechol [CPD:C00090];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.3.1.19 created 1972
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00362  Benzoate degradation
ec00623  Toluene degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16269  cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Genes
PPF: Pput_2877
PPX: T1E_4270(tobD)
PMON: X969_10950
PMOT: X970_10605
BPT: Bpet3742(hcaB)
Reference
1  [PMID:4362337]
  Authors
Axcell BC, Geary PJ.
  Title
The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase).
  Journal
Biochem J 136:927-34 (1973)
DOI:10.1042/bj1360927
Reference
2  [PMID:4298226]
  Authors
Gibson DT, Koch JR, Kallio RE.
  Title
Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene.
  Journal
Biochemistry 7:2653-62 (1968)
DOI:10.1021/bi00847a031
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.19
IUBMB Enzyme Nomenclature: 1.3.1.19
ExPASy - ENZYME nomenclature database: 1.3.1.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.19
BRENDA, the Enzyme Database: 1.3.1.19
CAS: 51923-03-6

KEGG   REACTION: R00812
Entry
R00812                      Reaction                               

Name
cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase
Definition
cis-1,2-Dihydrobenzene-1,2-diol + NAD+ <=> Catechol + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00386  C00090_C04091
Enzyme
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Orthology
K16269  cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]
Other DBs
RHEA: 15460

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