KEGG   ORTHOLOGY: K16305Help
Entry
K16305                      KO                                     

Name
K16305
Definition
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00051  Fructose and mannose metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00030 Pentose phosphate pathway
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00051 Fructose and mannose metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.11  6-deoxy-5-ketofructose 1-phosphate synthase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
BRITE hierarchy
Other DBs
RN: R01068 R01070 R02568 R10049 R10050
COG: COG1830
GO: 0004332
Genes
MKC: kam1_189
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MFS: MFS40622_0194
MIF: Metin_0355
MJH: JH146_0289
MIG: Metig_0068
MMP: MMP0293
MMQ: MmarC5_1380
MMD: GYY_01500
MAE: Maeo_0690
MVO: Mvol_1341
MBAK: MSBR3_2683
MMA: MM_0714
MMAC: MSMAC_0605
METM: MSMTP_0658
MTHE: MSTHC_0965
MTHR: MSTHT_2315
MHOR: MSHOH_0711
MPY: Mpsy_1203
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MLA: Mlab_1135
MEMA: MMAB1_2969
MPI: Mpet_1339
MPL: Mpal_0799
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]

KEGG   ENZYME: 2.2.1.11Help
Entry
EC 2.2.1.11                 Enzyme                                 

Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
MKC: kam1_189
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MFS: MFS40622_0194
MIF: Metin_0355
MJH: JH146_0289
MIG: Metig_0068
MMP: MMP0293
MMQ: MmarC5_1380
MMD: GYY_01500
MAE: Maeo_0690
MVO: Mvol_1341
MBAK: MSBR3_2683
MMA: MM_0714
MMAC: MSMAC_0605
METM: MSMTP_0658
MTHE: MSTHC_0965
MTHR: MSTHT_2315
MHOR: MSHOH_0711
MPY: Mpsy_1203
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MLA: Mlab_1135
MEMA: MMAB1_2969
MPI: Mpet_1339
MPL: Mpal_0799
 » show all
Taxonomy
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.11
IUBMB Enzyme Nomenclature: 2.2.1.11
ExPASy - ENZYME nomenclature database: 2.2.1.11
BRENDA, the Enzyme Database: 2.2.1.11

KEGG   REACTION: R10049Help
Entry
R10049                      Reaction                               

Name
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Definition
Methylglyoxal + D-Fructose 1,6-bisphosphate <=> D-Glyceraldehyde 3-phosphate + 6-Deoxy-5-ketofructose 1-phosphate
Equation
Reaction class
RC00439  C00118_C00354
RC02301  C00546_C16848
RC03034  C00354_C16848
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Other DBs
RHEA: 31914

DBGET integrated database retrieval system