KEGG   ORTHOLOGY: K16306Help
Entry
K16306                      KO                                     

Name
K16306
Definition
fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00051  Fructose and mannose metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00030 Pentose phosphate pathway
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00051 Fructose and mannose metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.10  2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
BRITE hierarchy
Other DBs
RN: R01068 R01070 R02568 R08568
COG: COG1830
GO: 0004332
Genes
MRM: A7982_01287
BMET: BMMGA3_07340
SRW: TUE45_01349(lsrF)
PSUB: Pelsub_P0311 Pelsub_P1007
MINF: MESINF_1405
MJA: MJ_0400
MFE: Mefer_1187
MVU: Metvu_1437
MFS: MFS40622_1668
MIF: Metin_0016
MMP: MMP0686
MMD: GYY_02835
MAE: Maeo_0316
MVO: Mvol_0365
MTH: MTH_579
MMG: MTBMA_c09600(fbaB)
METC: MTCT_0503
MWO: MWSIV6_0939(aroA')
METE: tca_00548(griI)
MST: Msp_0091
MSI: Msm_0056
MRU: mru_0997
MEB: Abm4_0656
MMIL: sm9_1016
MEYE: TL18_05340
MOL: YLM1_0540
METH: MBMB1_1070
MFC: BRM9_1272
MCUB: MCBB_0939(aroA')
MFV: Mfer_0600
MKA: MK1409(fbaB)
AFU: AF_0108
FPL: Ferp_0600
GAC: GACE_1261
GAH: GAH_01502
MEAR: Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: AR505_0508
MAC: MA_0439 MA_4591(deoC)
MBG: BN140_2035(fbaA1) BN140_2036(fbaA3)
MEZ: Mtc_1383(aroF) Mtc_1667
RCI: RRC153(aroF)
HAL: VNG_0309C
HSL: OE_1472F(fba2)
HHB: Hhub_1454
HALH: HTSR_1439(fba2)
HHSR: HSR6_1511(fba2)
HSU: HLASF_0623(fba1)
HSF: HLASA_0619(fba1)
HMA: rrnAC1881(deoC2)
HHI: HAH_2396(fbaB2)
NPH: NP_3160A(fba2)
NMO: Nmlp_1197(fba2)
HUT: Huta_1178
HTI: HTIA_1098
HMU: Hmuk_3036
HALL: LC1Hm_2379
HWA: HQ_1156A(fba2)
HWC: Hqrw_1193(fba2)
HVO: HVO_0790(fba2)
HME: HFX_0749(fbaB)
HLA: Hlac_1274
HTU: Htur_0853
NMG: Nmag_2815
NAT: NJ7G_4134
SALI: L593_00075
NMR: Nmar_0553
NID: NPIRD3C_1721(aroA)
NIN: NADRNF5_1625(aroA)
NCT: NMSP_1118(aroA'_2)
NGA: Ngar_c16210(aroGFH)
NVN: NVIE_005850(aroGFH)
NEV: NTE_01960
TAA: NMY3_02544(griI)
NFN: NFRAN_0128(aroA)
NCV: NCAV_0390(aroGFH)
NBV: T478_0480
NDV: NDEV_0554(aroA)
BARB: AOA66_0830(aroA')
LOKI: Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]

KEGG   ENZYME: 2.2.1.10Help
Entry
EC 2.2.1.10                 Enzyme                                 

Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
MRM: A7982_01287
BMET: BMMGA3_07340
SRW: TUE45_01349(lsrF)
PSUB: Pelsub_P0311 Pelsub_P1007
MINF: MESINF_1405
MJA: MJ_0400
MFE: Mefer_1187
MVU: Metvu_1437
MFS: MFS40622_1668
MIF: Metin_0016
MMP: MMP0686
MMD: GYY_02835
MAE: Maeo_0316
MVO: Mvol_0365
MTH: MTH_579
MMG: MTBMA_c09600(fbaB)
METC: MTCT_0503
MWO: MWSIV6_0939(aroA')
METE: tca_00548(griI)
MST: Msp_0091
MSI: Msm_0056
MRU: mru_0997
MEB: Abm4_0656
MMIL: sm9_1016
MEYE: TL18_05340
MOL: YLM1_0540
METH: MBMB1_1070
MFC: BRM9_1272
MCUB: MCBB_0939(aroA')
MFV: Mfer_0600
MKA: MK1409(fbaB)
AFU: AF_0108
FPL: Ferp_0600
GAC: GACE_1261
GAH: GAH_01502
MEAR: Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: AR505_0508
MAC: MA_0439 MA_4591(deoC)
MBG: BN140_2035(fbaA1) BN140_2036(fbaA3)
MEZ: Mtc_1383(aroF) Mtc_1667
RCI: RRC153(aroF)
HAL: VNG_0309C
HSL: OE_1472F(fba2)
HHB: Hhub_1454
HALH: HTSR_1439(fba2)
HHSR: HSR6_1511(fba2)
HSU: HLASF_0623(fba1)
HSF: HLASA_0619(fba1)
HMA: rrnAC1881(deoC2)
HHI: HAH_2396(fbaB2)
NPH: NP_3160A(fba2)
NMO: Nmlp_1197(fba2)
HUT: Huta_1178
HTI: HTIA_1098
HMU: Hmuk_3036
HALL: LC1Hm_2379
HWA: HQ_1156A(fba2)
HWC: Hqrw_1193(fba2)
HVO: HVO_0790(fba2)
HME: HFX_0749(fbaB)
HLA: Hlac_1274
HTU: Htur_0853
NMG: Nmag_2815
NAT: NJ7G_4134
SALI: L593_00075
NMR: Nmar_0553
NID: NPIRD3C_1721(aroA)
NIN: NADRNF5_1625(aroA)
NCT: NMSP_1118(aroA'_2)
NGA: Ngar_c16210(aroGFH)
NVN: NVIE_005850(aroGFH)
NEV: NTE_01960
TAA: NMY3_02544(griI)
NFN: NFRAN_0128(aroA)
NCV: NCAV_0390(aroGFH)
NBV: T478_0480
NDV: NDEV_0554(aroA)
BARB: AOA66_0830(aroA')
LOKI: Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Taxonomy
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.10
IUBMB Enzyme Nomenclature: 2.2.1.10
ExPASy - ENZYME nomenclature database: 2.2.1.10
BRENDA, the Enzyme Database: 2.2.1.10

KEGG   REACTION: R08568Help
Entry
R08568                      Reaction                               

Name
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Definition
L-Aspartate 4-semialdehyde + 6-Deoxy-5-ketofructose 1-phosphate <=> 2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + Hydroxypyruvaldehyde phosphate
Equation
Comment
possibly two-step reaction (aldehyde-lyase x2)
Reaction class
RC00721  C00441_C16850
RC02301  C16848_C16849
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Reference
1  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
Other DBs
RHEA: 25955

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