KEGG   ORTHOLOGY: K16339
Entry
K16339                      KO                                     
Symbol
THEM4, CTMP
Name
acyl-coenzyme A thioesterase THEM4 [EC:3.1.2.2]
Pathway
map00062  Fatty acid elongation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04151  PI3K-Akt signaling pathway
Reaction
R09450  long-chain fatty-acyl-CoA hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K16339  THEM4, CTMP; acyl-coenzyme A thioesterase THEM4
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K16339  THEM4, CTMP; acyl-coenzyme A thioesterase THEM4
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K16339  THEM4, CTMP; acyl-coenzyme A thioesterase THEM4
Other DBs
GO: 0016290
Genes
HSA: 117145(THEM4)
PTR: 457305(THEM4)
PPS: 100969253 100981869(THEM4)
GGO: 101140561(THEM4)
PON: 100440874(THEM4)
NLE: 100600341(THEM4)
HMH: 116469427(THEM4) 116481672
MCC: 711796(THEM4)
MCF: 102145205(THEM4)
MTHB: 126934473
MNI: 105497868(THEM4)
CSAB: 103224017
CATY: 105590243(THEM4)
PANU: 101012893(THEM4)
TGE: 112631666(THEM4)
MLEU: 105534708(THEM4)
RRO: 104681026(THEM4)
RBB: 108533212(THEM4)
TFN: 117074346 117074518(THEM4)
PTEH: 111543666(THEM4)
CANG: 105508937(THEM4)
CJC: 100400243(THEM4)
SBQ: 101034294(THEM4)
CIMI: 108316400(THEM4)
CSYR: 103263778(THEM4)
MMUR: 105873055(THEM4)
LCAT: 123635133(THEM4)
PCOQ: 105821748(THEM4)
OGA: 100964729(THEM4)
MMU: 75778(Them4)
MCAL: 110291876(Them4)
MPAH: 110320649(Them4)
RNO: 361992(Them4)
MCOC: 116093361(Them4)
ANU: 117707011(Them4)
MUN: 110565679(Them4)
CGE: 100769809(Them4)
MAUA: 106022699(Them4) 121138567
PROB: 127232747(Them4)
PLEU: 114683214(Them4)
MFOT: 126489951
AAMP: 119801433(Them4)
NGI: 103730047(Them4)
HGL: 101703857(Them4)
CPOC: 100721204(Them4)
CCAN: 109696693(Them4)
DORD: 105984736(Them4)
DSP: 122109437(Them4)
NCAR: 124959162
MMMA: 107156619(Them4)
OPI: 101535621(THEM4)
TUP: 102482524(THEM4)
GVR: 103607425
CFA: 609163(THEM4)
CLUD: 112663941(THEM4)
VVP: 112907787(THEM4)
VLG: 121491214(THEM4)
NPO: 129501433(THEM4)
AML: 100471932(THEM4)
UMR: 103667498(THEM4)
UAH: 113246173(THEM4)
UAR: 123787693(THEM4)
ELK: 111162045
LLV: 125098334
MPUF: 101677035(THEM4)
MNP: 132001490(THEM4)
MLK: 131809060(THEM4)
NVS: 122890259 122900522(THEM4)
ORO: 101365923(THEM4)
EJU: 114197336(THEM4)
ZCA: 113927968(THEM4)
MLX: 118000360(THEM4)
NSU: 110578501(THEM4)
FCA: 101084812(THEM4)
PYU: 121021085(THEM4)
PCOO: 112865363(THEM4)
PBG: 122481187(THEM4)
PVIV: 125159504(THEM4)
LRUF: 124515260
PTG: 102968396(THEM4)
PPAD: 109257030(THEM4)
PUC: 125912075
AJU: 106979970
HHV: 120241207(THEM4)
BTA: 787270(THEM4)
BOM: 102279271(THEM4)
BIU: 109554812(THEM4)
BBUB: 102392814(THEM4)
BBIS: 105001287(THEM4)
CHX: 102190188(THEM4)
OAS: 101119606(THEM4)
BTAX: 128045409(THEM4)
ODA: 120855860(THEM4)
CCAD: 122434847(THEM4)
MBEZ: 129541793(THEM4)
CFR: 102507666(THEM4)
CBAI: 105071701(THEM4)
CDK: 105103232(THEM4)
VPC: 102536142(THEM4)
BACU: 103002195(THEM4)
BMUS: 118892590(THEM4)
LVE: 103091662(THEM4)
OOR: 101285149(THEM4)
DLE: 111169719(THEM4)
PCAD: 102987336(THEM4)
PSIU: 116739888(THEM4)
NASI: 112411659(THEM4)
ECB: 100055681(THEM4)
EPZ: 103547926(THEM4)
EAI: 106848358(THEM4)
MYD: 102762592(THEM4)
MMYO: 118673388(THEM4)
MLF: 102417517(THEM4) 102427328
PKL: 118727290(THEM4)
EFUS: 103291375(THEM4)
MNA: 107540780(THEM4)
DRO: 112316018(THEM4)
SHON: 118996801(THEM4)
AJM: 119048123(THEM4)
PDIC: 114489007(THEM4)
PHAS: 123804296(THEM4)
MMF: 118637684(THEM4)
PPAM: 129062334(THEM4)
HAI: 109374393(THEM4)
RFQ: 117015148(THEM4) 117019794
PALE: 102897248(THEM4)
PGIG: 120616858
PVP: 105303852(THEM4)
RAY: 107500640(THEM4)
TOD: 119236868(THEM4)
SARA: 101548074(THEM4)
LAV: 100671841(THEM4)
TMU: 101360029
ETF: 101651134(THEM4)
DNM: 101414191
OAA: 100081588
GGA: 100858223(THEM4)
PCOC: 116238432
MGP: 104915960
CJO: 107324587
TPAI: 128071884
LMUT: 125685670
NMEL: 110387810
ACYG: 125181688
CATA: 118260476(THEM4)
AFUL: 116499717
OTC: 121338556
PRUF: 121360148
GFR: 106632128
OMA: 130263454
PHI: 102106344(THEM4)
CCAE: 111943895
SVG: 106863862(THEM4)
CLV: 102096765(THEM4)
ACHC: 115345946
HLE: 104831371(THEM4)
AGEN: 126041123
DPUB: 104296796(THEM4)
AAM: 106492217(THEM4)
AROW: 112974558
DNE: 112981972(THEM4)
SCAM: 104139779
AMJ: 102559435(THEM4) 109281033
CPOO: 109324823(THEM4)
PSS: 102461711(THEM4)
CMY: 102930379
CCAY: 125625840
DCC: 119847978
CPIC: 101935735
TST: 117869640
CABI: 116817640
MRV: 120390654
ACS: 100564032(them4)
ASAO: 132764213
SUND: 121916218
PBI: 103051027(THEM4) 103053373
PMUA: 114586840(THEM4)
PRAF: 128403769
ZVI: 118076540
HCG: 128337529
XLA: 443715(them4.L)
XTR: 101735170
NPR: 108797700(THEM4)
BGAR: 122921918
GSH: 117350581(THEM4)
DRE: 791152(them4)
SRX: 107749198
SANH: 107684185
SGH: 107596683
PTET: 122357986 122361099(them4)
LROH: 127179061(them4)
OMC: 131522359(them4)
PPRM: 120495045(them4)
RKG: 130070499(them4)
MAMB: 125243411(them4)
CIDE: 127497475
MASI: 127453393
TROS: 130557419(them4)
TDW: 130433367(them4)
MANU: 129448171(them4)
IFU: 128610937(them4)
PHYP: 113533692
SMEO: 124385248(them4)
TFD: 113644170(them4)
TVC: 132845850(them4)
AMEX: 103035109
CMAO: 118817925(them4)
EEE: 113575243
CHAR: 105901670(them4)
TRU: 101064761
TFS: 130532576(them4)
LCO: 104923063
NCC: 104959154
TBEN: 117480579(them4)
CGOB: 115021369
PGEO: 117461085(them4)
GACU: 117554035(them4)
EMAC: 134861036(them4)
ELY: 117266078(them4)
EFO: 125892680(them4)
PLEP: 121945200(them4)
SLUC: 116049522(them4)
ECRA: 117946378(them4)
ESP: 116691712
PFLV: 114557733
GAT: 120810648(them4)
PPUG: 119197839(them4)
AFB: 129109797(them4)
CLUM: 117745336(them4)
PSWI: 130212898(them4)
MSAM: 119897620(them4)
SCHU: 122882205(them4)
CUD: 121513201(them4)
ALAT: 119005335(them4)
MZE: 101466288
ONL: 100702377
OAU: 116315660(them4)
OLA: 101172604
OML: 112143157(them4)
CSAI: 133441012(them4)
XMA: 102232383
XCO: 114142257
XHE: 116717066
PRET: 103478140
PFOR: 103140893
PLAI: 106937890
PMEI: 106916281
GAF: 122831227(them4)
PPRL: 129371267(them4)
CVG: 107096308
CTUL: 119786686(them4)
GMU: 124864046(them4)
NFU: 107379750
KMR: 108241061(them4)
ALIM: 106533283
NWH: 119410049(them4)
AOCE: 111582981
MCEP: 125016854(them4)
POV: 109633040(them4)
SSEN: 122774205(them4)
HHIP: 117776660(them4)
HSP: 118114312(them4)
SMAU: 118292469(them4)
LCF: 108889573(them4)
SDU: 111237209
SLAL: 111650907
XGL: 120783706(them4)
HCQ: 109529029
SSCV: 125975429
SBIA: 133500877(them4)
PEE: 133402036(them4)
PTAO: 133479716(them4)
BPEC: 110163137
MALB: 109964143
BSPL: 114843489(them4)
SJO: 128366344(them4)
OTW: 121841044
OMY: 110508333(them4)
OGO: 124017014
OKI: 109901399
OKE: 118383136
SALP: 111964813
SNH: 120048794(them4)
CCLU: 121542412(them4)
ELS: 105029233
SFM: 108924938
PKI: 111838445
AANG: 118219718(them4)
LOC: 102691049
PSPA: 121309833(them4)
PSEX: 120537609(them4)
PMRN: 116943050
BBEL: 109486495
SPU: 753049
LPIC: 129276151
SKO: 102808799
EPA: 110243139
ATEN: 116299934
AMIL: 114959498
PDAM: 113681596
SPIS: 111321718
MPP: MICPUCDRAFT_58619(JGI:MicpuC2_58619)
MGR: MGG_10034
PTE: PTT_15054
SPAR: SPRG_04086
 » show all
Reference
  Authors
Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA
  Title
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
  Journal
Science 294:374-80 (2001)
DOI:10.1126/science.1062030
  Sequence
[hsa:117145]

KEGG   ORTHOLOGY: K17360
Entry
K17360                      KO                                     
Symbol
ACOT7
Name
acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]
Pathway
map00062  Fatty acid elongation
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R01274  palmitoyl-CoA hydrolase
R08174  stearoyl-CoA hydrolase
R08176  oleoyl-CoA hydrolase
R08177  linoleoyl-CoA hydrolase
R08178  
R08181  
R09450  long-chain fatty-acyl-CoA hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K17360  ACOT7; acyl-coenzyme A thioesterase 7
   01040 Biosynthesis of unsaturated fatty acids
    K17360  ACOT7; acyl-coenzyme A thioesterase 7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K17360  ACOT7; acyl-coenzyme A thioesterase 7
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K17360  ACOT7; acyl-coenzyme A thioesterase 7
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K17360  ACOT7; acyl-coenzyme A thioesterase 7
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K17360  ACOT7; acyl-coenzyme A thioesterase 7
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K17360  ACOT7; acyl-coenzyme A thioesterase 7
Other DBs
GO: 0016290
Genes
HSA: 11332(ACOT7)
PTR: 100609278 745616(ACOT7)
PPS: 100977829(ACOT7) 100978366
GGO: 101126562(ACOT7) 101140727
PON: 100173009(ACOT7)
NLE: 100581694(ACOT7) 100591490
HMH: 116456657 116812845(ACOT7)
MCC: 703288(ACOT7) 705407
MCF: 101866731(ACOT7) 102120236
MTHB: 126952575
MNI: 105479612(ACOT7) 105487726
CSAB: 103225695(ACOT7) 103246191
CATY: 105580943(ACOT7)
PANU: 101008252 101009689(ACOT7)
TGE: 112636333(ACOT7)
MLEU: 105540534(ACOT7) 105542154
RRO: 104657575(ACOT7) 104679127
RBB: 108517951(ACOT7)
TFN: 117093402(ACOT7)
PTEH: 111534758 111544611(ACOT7)
CANG: 105509161(ACOT7) 105516771
CJC: 100390157(ACOT7) 100409427
SBQ: 101032149(ACOT7)
CIMI: 108282372(ACOT7) 108315899
CSYR: 103258638(ACOT7)
MMUR: 105886115
LCAT: 123634551(ACOT7)
PCOQ: 105824975(ACOT7)
OGA: 100945377(ACOT7)
MMU: 70025(Acot7)
MCAL: 110292926(Acot7)
MPAH: 110322920(Acot7)
RNO: 26759(Acot7)
MCOC: 116097092(Acot7)
ANU: 117709257(Acot7)
MUN: 110552721(Acot7)
CGE: 100755154(Acot7)
MAUA: 101826987(Acot7)
PROB: 127213501(Acot7)
PLEU: 114702615(Acot7)
MORG: 121448036(Acot7)
MFOT: 126508177
AAMP: 119816492(Acot7)
NGI: 103725124(Acot7)
HGL: 101705865(Acot7)
CPOC: 100725212(Acot7)
CCAN: 109688362(Acot7)
DORD: 106000306(Acot7)
DSP: 122102215(Acot7)
PLOP: 125354511(Acot7)
NCAR: 124978275
MMMA: 107155554(Acot7) 107159506
OCU: 100354701
OPI: 101517685(ACOT7)
TUP: 102478970(ACOT7)
GVR: 103585899(ACOT7)
CFA: 479589(ACOT7)
CLUD: 112646927(ACOT7)
VVP: 112924697(ACOT7)
VLG: 121500761(ACOT7)
NPO: 129497472(ACOT7)
AML: 100469263(ACOT7)
UMR: 103666697(ACOT7)
UAH: 113270572(ACOT7)
UAR: 123796156(ACOT7)
ELK: 111154684
MPUF: 101671178(ACOT7)
MNP: 132002288(ACOT7) 132013166
MLK: 131808899(ACOT7) 131826664
NVS: 122899383(ACOT7)
ORO: 101376949(ACOT7)
EJU: 114213162(ACOT7)
ZCA: 113909339(ACOT7)
MLX: 118020066(ACOT7)
NSU: 110574631(ACOT7)
LWW: 102741618
FCA: 101090371(ACOT7)
PYU: 121019917(ACOT7)
PCOO: 112868019(ACOT7)
PBG: 122479862(ACOT7)
PVIV: 125173551(ACOT7)
LRUF: 124516387
PTG: 102956825(ACOT7)
PPAD: 109274019(ACOT7)
PUC: 125913170
AJU: 106982203
HHV: 120244056 120245990(ACOT7)
BTA: 514788(ACOT7)
BOM: 102279443(ACOT7)
BIU: 109570593(ACOT7)
BBUB: 102391823(ACOT7)
BBIS: 104996068(ACOT7)
CHX: 102180523(ACOT7)
OAS: 101121789(ACOT7)
BTAX: 128061367(ACOT7)
ODA: 120880143(ACOT7)
CCAD: 122452080(ACOT7)
MBEZ: 129551468(ACOT7)
SSC: 100514773(ACOT7)
CFR: 102517012(ACOT7)
CBAI: 105071017(ACOT7)
CDK: 105104722(ACOT7)
VPC: 102541330(ACOT7)
BACU: 102998002(ACOT7)
BMUS: 118900741(ACOT7)
LVE: 103076361(ACOT7)
OOR: 101269957(ACOT7)
DLE: 111187100(ACOT7)
PCAD: 102977545(ACOT7)
PSIU: 116756150(ACOT7)
NASI: 112406999(ACOT7)
ECB: 100059575(ACOT7)
EPZ: 103558985(ACOT7)
EAI: 106844539(ACOT7)
MYB: 102260728(ACOT7)
MYD: 102752282(ACOT7)
MMYO: 118675910(ACOT7)
MLF: 102421351(ACOT7)
PKL: 118705207 118731990(ACOT7)
EFUS: 103295292(ACOT7)
MNA: 107538453(ACOT7)
DRO: 112299443(ACOT7)
SHON: 118998139(ACOT7)
AJM: 119055949(ACOT7)
PDIC: 114496265(ACOT7)
PHAS: 123831685(ACOT7)
MMF: 118626629(ACOT7)
PPAM: 129078494(ACOT7)
HAI: 109392168(ACOT7)
RFQ: 117027445(ACOT7)
PALE: 102887428(ACOT7)
PGIG: 120585709(ACOT7)
PVP: 105297688(ACOT7)
RAY: 107521002(ACOT7)
MJV: 108406613(ACOT7)
TOD: 119235762(ACOT7)
SARA: 101545213(ACOT7)
LAV: 100667124(ACOT7)
TMU: 101344810
ETF: 101652199(ACOT7)
DNM: 101417393(ACOT7)
MDO: 100026645(ACOT7)
GAS: 123240949(ACOT7) 123254827
SHR: 100918199(ACOT7)
AFZ: 127555938
PCW: 110199988(ACOT7)
OAA: 100084547(ACOT7)
GGA: 419371(ACOT7)
PCOC: 116242561(ACOT7)
MGP: 100547443(ACOT7)
CJO: 107323462(ACOT7)
TPAI: 128084939(ACOT7)
LMUT: 125703423(ACOT7)
NMEL: 110408754(ACOT7)
APLA: 101789631(ACOT7)
ACYG: 106047220(ACOT7)
CATA: 118253279(ACOT7)
AFUL: 116497671(ACOT7)
TGU: 100232141(ACOT7)
LSR: 110472517(ACOT7)
SCAN: 103820821(ACOT7)
PMOA: 120511057(ACOT7)
OTC: 121344084(ACOT7)
PRUF: 121358475(ACOT7)
GFR: 102035195(ACOT7)
FAB: 101807279(ACOT7)
OMA: 130261817(ACOT7)
PHI: 102114502(ACOT7)
PMAJ: 107213584(ACOT7)
CCAE: 111938605(ACOT7)
CCW: 104693276(ACOT7)
CBRC: 103616145(ACOT7)
ETL: 114060107(ACOT7)
ZAB: 102069647(ACOT7)
ACHL: 103799648(ACOT7)
SVG: 106857684(ACOT7)
MMEA: 130579080(ACOT7)
HRT: 120762352(ACOT7)
FPG: 101917751(ACOT7)
FCH: 102046133(ACOT7)
CLV: 102086257(ACOT7)
EGZ: 104132040(ACOT7)
NNI: 104008928(ACOT7)
PCRI: 104032839(ACOT7)
PLET: 104617575(ACOT7)
EHS: 104516796(ACOT7)
ACUN: 113487926(ACOT7)
TALA: 104361258(ACOT7)
PADL: 103916262(ACOT7)
AFOR: 103894689(ACOT7)
ACHC: 115342663(ACOT7)
HLE: 104830455(ACOT7)
AGEN: 126039955
GCL: 127024661
CCRI: 104169531(ACOT7)
CSTI: 104562707(ACOT7)
CMAC: 104480029(ACOT7)
MUI: 104545849(ACOT7)
BREG: 104644016(ACOT7)
FGA: 104073993(ACOT7)
GSTE: 104261368(ACOT7)
MNB: 103775747(ACOT7)
OHA: 104333814(ACOT7)
NNT: 104408015(ACOT7)
SHAB: 115617406(ACOT7)
DPUB: 104309894(ACOT7)
PGUU: 104471978(ACOT7)
CPEA: 104395501(ACOT7)
AVIT: 104270985(ACOT7)
CVF: 104290520(ACOT7)
RTD: 128918443(ACOT7)
CUCA: 104059868(ACOT7)
TEO: 104380826(ACOT7)
AAM: 106492668(ACOT7)
AROW: 112975499(ACOT7)
NPD: 112957481(ACOT7)
TGT: 104570538(ACOT7)
DNE: 112995694(ACOT7)
SCAM: 104141971(ACOT7)
ASN: 102371135(ACOT7)
AMJ: 102558083(ACOT7)
CPOO: 109314184(ACOT7)
GGN: 109293592(ACOT7)
PSS: 102461234(ACOT7)
CMY: 102930522(ACOT7)
CCAY: 125624359(ACOT7)
DCC: 119845026(ACOT7)
CPIC: 101937143(ACOT7)
TST: 117867834(ACOT7)
CABI: 116815425(ACOT7)
MRV: 120387821(ACOT7)
ACS: 100551908(acot7)
ASAO: 132764971(ACOT7)
PVT: 110082432(ACOT7)
SUND: 121937104(ACOT7)
PBI: 103057456(ACOT7)
PMUR: 107284665(ACOT7)
CTIG: 120318977(ACOT7)
TSR: 106549354(ACOT7)
APRI: 131187165(ACOT7)
PTEX: 113449780(ACOT7)
NSS: 113423996(ACOT7)
VKO: 123017964(ACOT7)
PMUA: 114602351(ACOT7)
PRAF: 128419571(ACOT7)
ZVI: 118087070(ACOT7)
HCG: 128338600(ACOT7)
GJA: 107110578(ACOT7)
STOW: 125445942(ACOT7)
EMC: 129344670(ACOT7)
XLA: 108696607(acot7.L) 108697249
XTR: 779821(acot7)
NPR: 108804694(ACOT7)
RTEM: 120915897(ACOT7)
BBUF: 120998804(ACOT7)
BGAR: 122928861(ACOT7)
MUO: 115456674(ACOT7)
GSH: 117349266(ACOT7)
DRE: 447878(acot7)
SGH: 107595775(acot7) 107602443
CCAR: 109079283 109090561(acot7)
PTET: 122350041(acot7)
LROH: 127169211(acot7)
OMC: 131545587(acot7)
PPRM: 120473773(acot7)
RKG: 130082017(acot7)
MAMB: 125280321(acot7)
CIDE: 127517611
TROS: 130549590(acot7)
TDW: 130440061(acot7)
MANU: 129414057(acot7)
IPU: 108265054
IFU: 128607580(acot7)
PHYP: 113533403(acot7)
SMEO: 124400036(acot7)
TFD: 113656156(acot7)
TVC: 132854013(acot7)
AMEX: 103037715(acot7)
CMAO: 118813585(acot7)
EEE: 113578178(acot7)
CHAR: 105899067(acot7)
TRU: 101075291(acot7)
TFS: 130529701(acot7)
LCO: 104926410(acot7)
NCC: 104945179(acot7)
TBEN: 117494154(acot7)
CGOB: 115011378(acot7)
PGEO: 117450171(acot7)
GACU: 117541805(acot7)
EMAC: 134869875(acot7)
ELY: 117265632(acot7)
EFO: 125892163(acot7)
PLEP: 121947039(acot7)
SLUC: 116040723(acot7)
ECRA: 117947331(acot7)
ESP: 116692623(acot7)
PFLV: 114558725(acot7)
GAT: 120829582(acot7)
PPUG: 119199154 119221875(acot7)
AFB: 129100045(acot7)
CLUM: 117734155(acot7)
PSWI: 130199859(acot7)
MSAM: 119906222(acot7)
SCHU: 122882766(acot7)
CUD: 121517683(acot7)
ALAT: 119023283(acot7)
MZE: 101466734(acot7)
ONL: 100693869(acot7)
OAU: 116319009(acot7)
OLA: 101167535(acot7)
OML: 112158850(acot7)
CSAI: 133456521(acot7)
XMA: 102237860(acot7)
XCO: 114143995(acot7)
XHE: 116725419(acot7)
PRET: 103467275(acot7)
PFOR: 103138987(acot7)
PLAI: 106944882(acot7)
PMEI: 106915561(acot7)
GAF: 122832358(acot7)
PPRL: 129372477(acot7)
CVG: 107086633(acot7)
CTUL: 119795506(acot7)
GMU: 124871268(acot7)
NFU: 107390695(acot7)
KMR: 108236744(acot7)
ALIM: 106513033(acot7)
AOCE: 111568959(acot7)
MCEP: 125000571(acot7)
CSEM: 103384470(acot7)
POV: 109630639(acot7)
SSEN: 122776596(acot7) 122785260
HHIP: 117764841(acot7)
HSP: 118110356(acot7)
SMAU: 118316548(acot7)
LCF: 108891665
SDU: 111219165(acot7)
SLAL: 111670592(acot7)
XGL: 120803407(acot7)
HCQ: 109514761(acot7)
SSCV: 125988390
SBIA: 133508827(acot7)
PEE: 133405335(acot7)
PTAO: 133483007(acot7)
MALB: 109971641(acot7)
BSPL: 114858821(acot7)
SJO: 128356842(acot7)
SASA: 106572204(acot7)
STRU: 115166104(acot7)
OTW: 112233041(acot7)
OMY: 110532161(acot7)
OGO: 124031835(acot7)
ONE: 115132045(acot7)
OKI: 109907895(acot7)
OKE: 118361244(acot7)
SALP: 111966348(acot7)
SNH: 120059409(acot7)
CCLU: 121538227(acot7)
ELS: 105013849(acot7)
SFM: 108924916(acot7)
PKI: 111859134(acot7)
AANG: 118208287(acot7)
LOC: 102684375(acot7)
PSEX: 120531078(acot7)
LCM: 102366520(ACOT7)
CMK: 103184198(acot7)
CPLA: 122540397(acot7)
HOC: 132833625(acot7)
LERI: 129711754(acot7)
PMRN: 116950453(ACOT7)
LRJ: 133352513(ACOT7)
BFO: 118423242
BBEL: 109473649
CIN: 100182032
SCLV: 120328556
APLC: 110976520
AJC: 117121393
GAE: 121392620
LAK: 106174341
NVE: 5509371
EPA: 110249056
ATEN: 116298702
ADF: 107327053
AMIL: 114969955
PDAM: 113679915
SPIS: 111344207
DGT: 114518382
XEN: 124444608
HSY: 130640905
AQU: 100635222
 » show all
Reference
  Authors
Ellis JM, Wong GW, Wolfgang MJ
  Title
Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity.
  Journal
Mol Cell Biol 33:1869-82 (2013)
DOI:10.1128/MCB.01548-12
  Sequence
[mmu:70025]
Reference
  Authors
Kuramochi Y, Takagi-Sakuma M, Kitahara M, Emori R, Asaba Y, Sakaguchi R, Watanabe T, Kuroda J, Hiratsuka K, Nagae Y, Suga T, Yamada J
  Title
Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization.
  Journal
Brain Res Mol Brain Res 98:81-92 (2002)
DOI:10.1016/S0169-328X(01)00323-0
  Sequence
[mmu:70025]

KEGG   ORTHOLOGY: K01068
Entry
K01068                      KO                                     
Symbol
ACOT1_2_4
Name
acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
Pathway
map00062  Fatty acid elongation
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04913  Ovarian steroidogenesis
Reaction
R01274  palmitoyl-CoA hydrolase
R08174  stearoyl-CoA hydrolase
R08175  icosanoyl-CoA hydrolase
R08176  oleoyl-CoA hydrolase
R08177  linoleoyl-CoA hydrolase
R08178  
R08179  (5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA hydrolase
R08180  
R08181  
R08182  
R08183  
R09450  long-chain fatty-acyl-CoA hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
   01040 Biosynthesis of unsaturated fatty acids
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Other DBs
COG: COG1946
GO: 0016290
Genes
HSA: 10965(ACOT2) 122970(ACOT4) 641371(ACOT1)
PTR: 453017(ACOT2) 453018(ACOT4)
PPS: 100971608(ACOT2) 100973111(ACOT4)
GGO: 101139031(ACOT2) 101139653(ACOT4)
PON: 100442699 100443692(ACOT4) 100444412(ACOT2)
NLE: 100591629 100600674 100601709(ACOT4)
HMH: 116484626 116484653 116484793(ACOT4)
MCC: 697011(ACOT2) 697131(ACOT4)
MCF: 101925489(ACOT2) 102144834(ACOT4)
MTHB: 126959533 126959538
MNI: 105494284
CSAB: 103229305(ACOT4) 103229306
PANU: 101003993 101004347(ACOT4)
MLEU: 105541855(ACOT4) 105541879(ACOT2) 105541881
RRO: 104662094 104677548(ACOT2) 104677549(ACOT4)
PTEH: 111520549 111520556(ACOT4)
CANG: 105517184(ACOT2) 105517185(ACOT4)
CJC: 100404918(ACOT4)
SBQ: 101029645(ACOT4)
CSYR: 103273240
MMU: 171210(Acot2) 171281(Acot3) 171282(Acot4) 217698(Acot5) 26897(Acot1)
RNO: 192272(Acot2) 314304(Acot3) 503049(Acot5) 50559(Acot1) 681337(Acot4)
HGL: 101722826
TUP: 102487858 102502559(ACOT4) 102502991(ACOT2)
GVR: 103599833(ACOT4) 103599897
CFA: 490770 490771(ACOT4)
CLUD: 112657831 112657832(ACOT4)
VVP: 112927252(ACOT4)
VLG: 121493578
NPO: 129496023 129496025(ACOT4)
ELK: 111140503
ORO: 101365289 101378920(ACOT4)
EJU: 114199379 114207764(ACOT4)
NSU: 110571431(ACOT4) 110580062
LWW: 102736135(ACOT4) 102740458
PUC: 125917563
BTA: 511033(ACOT2) 511431(ACOT4) 512541 785383
CFR: 102507701 116664344(ACOT4)
CBAI: 105075438 105075447(ACOT4)
CDK: 105086124 105086252(ACOT4)
VPC: 102545132
BACU: 102997243(ACOT4) 103004901(ACOT2)
BMUS: 118890285 118890287(ACOT4)
LVE: 103071761(ACOT4) 103072862(ACOT2) 103079978
OOR: 101276207 101276466(ACOT4)
DLE: 111176277 111176280(ACOT4)
PCAD: 102980644(ACOT4) 102981477
PSIU: 116749076(ACOT4) 116749791
EPZ: 103543883(ACOT4) 103545366
MYB: 102254770 102258610(ACOT1) 102258906(ACOT4)
MYD: 102759368(ACOT2) 102759648(ACOT4)
MMYO: 118657803 118657821(ACOT4)
MLF: 102440418 102441032(ACOT4)
EFUS: 103283892 129147054(ACOT4)
DRO: 112311477
SHON: 118976680
AJM: 119035528(ACOT4)
HAI: 109381542 109381571(ACOT4)
RFQ: 117022754 117022756(ACOT4)
PGIG: 120619479(ACOT4)
PVP: 105299271
MJV: 108397199(ACOT4)
SARA: 101546815
LAV: 100670605 100670886(ACOT4)
DNM: 101439958 101440394(ACOT4)
MDO: 100024487(ACOT2)
SHR: 100913369
PCW: 110208487
GGA: 423222(ACOT1L) 423247(ACOT2L) 428872(ACOT4)
CCAE: 111930084
AVIT: 104275260
AMJ: 102560956 102561188(ACOT1)
TSR: 106541789
XLA: 108699174 108699179(acot2.L) 414573(acot2.S)
XTR: 100144968(acot2) 100498625
DRE: 492778(acot19) 553440(acot20) 562047(acot21)
SGH: 107595264
PTET: 122324598(acot20) 122330984(acot19)
LROH: 127157115(acot19) 127183339(acot20)
OMC: 131527457(acot20) 131533937(acot19)
PPRM: 120459102(acot19) 120493728(acot20) 120493729
RKG: 130075494(acot20) 130099281(acot19)
TROS: 130565597(acot20)
TDW: 130414688(acot19) 130434762(acot20)
IPU: 108257587(acot20) 108275292(acot19) 108279984
IFU: 128600928(acot20) 128618552(acot19)
SMEO: 124377008(acot20) 124391878(acot19) 124392265
TFD: 113658040(acot20)
APLC: 110978425
CLON: 129617032
PMOO: 119592226
EAF: 111697602
TCF: 131887779
BGT: 106080254
CANU: 128175586
OED: 125652745
NVE: 5506196
ATEN: 116306587
PDAM: 113665009
SPIS: 111329196
DGT: 114517224
THJ: 104814102
CPAP: 110819430
PVY: 116142639
TCC: 18614145
GRA: 105802688
GHI: 107923939
GAB: 108474131
LJA: Lj0g3v0161459.1(Lj0g3v0161459.1) Lj1g3v2658230.1(Lj1g3v2658230.1) Lj1g3v2658230.2(Lj1g3v2658230.2) Lj1g3v2658230.3(Lj1g3v2658230.3) Lj1g3v2658230.4(Lj1g3v2658230.4) Lj1g3v2658230.5(Lj1g3v2658230.5) Lj1g3v2658230.6(Lj1g3v2658230.6)
PCIN: 129291271
FVE: 101302104
RCN: 112182258
PPER: 18784798
PMUM: 103331993
PAVI: 110744916
PDUL: 117619726
ZJU: 107404880
MNT: 21400292
CSAV: 115706516
CSV: 101222848
CMO: 103483275
BHJ: 120092474
MCHA: 111016341
RCU: 8261870
JCU: 105642991
POP: 7464929
PEU: 105133760
PALZ: 118041654
CAVE: 132186252
QSU: 112035681
VVI: 100256759
VRI: 117932638
CANN: 107839179
LBB: 132645586
NSY: 104243361
NTO: 104100056
NAU: 109207941
INI: 109184689
ITR: 116014946
SIND: 105173170
EGT: 105960549
SMIL: 131020677
APAN: 127252528
CSIN: 114294903
RVL: 131315109
SOE: 110789465
ATRI: 130811305
MOF: 131166183
NNU: 104586388
MING: 122086263
TSS: 122666177
OSA: 4336637
DOSA: Os04t0558400-01(Os04g0558400)
OBR: 102718259
OGL: 127771214
BDI: 100842302
ATS: 109761356
TUA: 125539372
LPER: 127335979
ZMA: 100273486
SITA: 101781418
SVS: 117863992
PHAI: 112899284
PDA: 103722362
EGU: 105034433
DCT: 110094120
PEQ: 110032560
NCOL: 116252603
ATR: 18423021
SCE: YJR019C(TES1)
SEUB: DI49_3034
ERC: Ecym_7379
KMX: KLMA_60086(TES1)
NCS: NCAS_0D01710(NCAS0D01710)
NDI: NDAI_0C02900(NDAI0C02900)
TPF: TPHA_0A04850(TPHA0A04850)
TBL: TBLA_0H02360(TBLA0H02360)
TDL: TDEL_0E04960(TDEL0E04960)
KAF: KAFR_0E01960(KAFR0E01960)
KNG: KNAG_0M01300(KNAG0M01300)
 » show all
Reference
  Authors
Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE
  Title
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
  Journal
FASEB J 20:1855-64 (2006)
DOI:10.1096/fj.06-6042com
  Sequence

KEGG   ORTHOLOGY: K22554
Entry
K22554                      KO                                     
Symbol
THEM5
Name
acyl-coenzyme A thioesterase THEM5 [EC:3.1.2.2]
Pathway
map00062  Fatty acid elongation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R09450  long-chain fatty-acyl-CoA hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K22554  THEM5; acyl-coenzyme A thioesterase THEM5
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K22554  THEM5; acyl-coenzyme A thioesterase THEM5
Other DBs
GO: 0047617
Genes
HSA: 284486(THEM5)
PTR: 457304(THEM5)
PPS: 100983203(THEM5)
GGO: 101139248(THEM5)
PON: 100441238(THEM5)
NLE: 100600007(THEM5)
HMH: 116469426(THEM5)
MCC: 100430689(THEM5)
MCF: 102116302(THEM5)
MTHB: 126952598
MNI: 105497865(THEM5)
CATY: 105590305(THEM5)
PANU: 101012541(THEM5)
TGE: 112618686(THEM5)
MLEU: 105534709(THEM5)
RRO: 104681027(THEM5)
RBB: 108533222(THEM5)
TFN: 117076104(THEM5)
PTEH: 111543664(THEM5)
CANG: 105508886(THEM5)
CJC: 100393740(THEM5)
CIMI: 108316407(THEM5)
CSYR: 103263773(THEM5)
MMUR: 105873053(THEM5) 105874499
LCAT: 123635132(THEM5)
PCOQ: 105821750(THEM5)
OGA: 100964833(THEM5)
MMU: 66198(Them5)
MCAL: 110291753(Them5)
MPAH: 110320928(Them5)
RNO: 361993(Them5)
MCOC: 116094174(Them5)
ANU: 117707107(Them5)
MUN: 110565676(Them5)
CGE: 100769525(Them5)
MAUA: 101838724(Them5)
PROB: 127232772(Them5)
PLEU: 114683232(Them5)
MFOT: 126489950
AAMP: 119801491(Them5)
NGI: 103730048(Them5)
HGL: 101702565(Them5) 101705063
CPOC: 100720929(Them5)
CCAN: 109696697(Them5)
DORD: 105984936(Them5)
DSP: 122109650(Them5)
PLOP: 125359961(Them5)
NCAR: 124959151
MMMA: 107156791(Them5)
OCU: 100353032
OPI: 101535120(THEM5)
TUP: 102482962(THEM5) 102497766
GVR: 103592422(THEM5)
CFA: 608399(THEM5)
CLUD: 112663943(THEM5)
VVP: 112907785(THEM5)
VLG: 121492017(THEM5)
NPO: 129501432(THEM5)
AML: 100481250(THEM5)
UMR: 103667500(THEM5)
UAH: 113246103(THEM5)
UAR: 123787697(THEM5)
ELK: 111161966
LLV: 125098337
MPUF: 101683063(THEM5)
MNP: 132000778(THEM5)
MLK: 131809879(THEM5)
NVS: 122900523(THEM5)
ORO: 101362338(THEM5)
EJU: 114197232(THEM5)
ZCA: 113927953(THEM5)
MLX: 118000362(THEM5)
NSU: 110578584(THEM5)
LWW: 102744892(THEM5)
FCA: 101082506(THEM5)
PYU: 121021086(THEM5)
PCOO: 112848608(THEM5)
PBG: 122481186(THEM5)
PVIV: 125159510(THEM5)
LRUF: 124516412
PTG: 102961219(THEM5)
PPAD: 109257091(THEM5)
PUC: 125912080
AJU: 106980050
BTA: 525765(THEM5)
BOM: 102278986(THEM5)
BIU: 109557012(THEM5)
BBUB: 102392491(THEM5)
BBIS: 105001288(THEM5)
CHX: 102187994 102190478(THEM5)
OAS: 101113538 101119950(THEM5)
BTAX: 128045730(THEM5)
ODA: 120855859(THEM5) 120867798
CCAD: 122427282(THEM5)
MBEZ: 129541416(THEM5)
SSC: 100622268(THEM5)
CFR: 102508662(THEM5)
CBAI: 105071702(THEM5)
CDK: 105103231(THEM5)
VPC: 102535879(THEM5)
BACU: 103012688(THEM5)
BMUS: 118902310(THEM5)
LVE: 103069390(THEM5)
OOR: 101287201(THEM5)
DLE: 111169788(THEM5)
PCAD: 102987051(THEM5)
PSIU: 116763283(THEM5)
NASI: 112411640(THEM5)
ECB: 100060159(THEM5) 102147639
EPZ: 103547109 103547925(THEM5)
EAI: 106848360(THEM5)
MYB: 102245585(THEM5)
MYD: 102762307(THEM5)
MMYO: 118673637(THEM5)
MLF: 102416889(THEM5)
PKL: 118727292(THEM5)
EFUS: 103291260(THEM5)
MNA: 107540779(THEM5)
DRO: 112318347(THEM5)
SHON: 118996800(THEM5)
AJM: 119048125(THEM5)
PDIC: 114489034(THEM5)
PHAS: 123804297(THEM5)
MMF: 118637774(THEM5)
PPAM: 129062126(THEM5)
HAI: 109374382(THEM5)
RFQ: 117015089(THEM5)
PALE: 102894686(THEM5)
PGIG: 120585261(THEM5)
PVP: 105303853(THEM5)
RAY: 107500607(THEM5)
MJV: 108396773(THEM5)
TOD: 119235913(THEM5)
SARA: 101547807(THEM5)
LAV: 100672138(THEM5)
ETF: 101642946(THEM5)
DNM: 101440219(THEM5)
MDO: 100019143(THEM5)
GAS: 123247316
SHR: 100923968(THEM5)
AFZ: 127559054
PCW: 110216966(THEM5)
OAA: 100091409(THEM5)
 » show all
Reference
  Authors
Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA
  Title
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
  Journal
Mol Cell Biol 32:2685-97 (2012)
DOI:10.1128/MCB.00312-12
  Sequence
[hsa:284486]

DBGET integrated database retrieval system