KEGG   ORTHOLOGY: K16421Help
Entry
K16421                      KO                                     

Name
hmaS, nocF
Definition
4-hydroxymandelate synthase [EC:1.13.11.46]
Pathway
ko00261  Monobactam biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.46  4-hydroxymandelate synthase
     K16421  hmaS, nocF; 4-hydroxymandelate synthase
BRITE hierarchy
Other DBs
RN: R06632
GO: 0050585
Genes
MSD: MYSTI_03600
AGE: AA314_04078
THAA: CFI11_12525
NTP: CRH09_30890(hppD)
SCO: SCO3229(SCE63.04)
SVL: Strvi_8789
SBH: SBI_01126
SRC: M271_09160 M271_27680
SALU: DC74_563
SALL: SAZ_03310
STRE: GZL_08687
SLAU: SLA_6884
KFL: Kfla_6066
SRO: Sros_6970
AOI: AORI_1495(hppD)
AMI: Amir_4590
KAL: KALB_6132
ACTI: UA75_15380
ACAD: UA74_14810
ACTA: C1701_23410(hppD)
SAQ: Sare_2673
MIL: ML5_4909
MTUA: CSH63_07635(hppD)
MICH: FJK98_16440(hppD)
CAI: Caci_3256
HAU: Haur_1888
AG: CAA11761(hmaS)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3229]

KEGG   ENZYME: 1.13.11.46Help
Entry
EC 1.13.11.46               Enzyme                                 

Name
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]
Reaction(KEGG)
R06632;
(other) R05778
Show
Substrate
4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]
Product
(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]
Comment
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
History
EC 1.13.11.46 created 2001
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K16421  4-hydroxymandelate synthase
Genes
MSD: MYSTI_03600
AGE: AA314_04078
THAA: CFI11_12525
NTP: CRH09_30890(hppD)
SCO: SCO3229(SCE63.04)
SVL: Strvi_8789
SBH: SBI_01126
SRC: M271_09160 M271_27680
SALU: DC74_563
SALL: SAZ_03310
STRE: GZL_08687
SLAU: SLA_6884
KFL: Kfla_6066
SRO: Sros_6970
AOI: AORI_1495(hppD)
AMI: Amir_4590
KAL: KALB_6132
ACTI: UA75_15380
ACAD: UA74_14810
ACTA: C1701_23410(hppD)
SAQ: Sare_2673
MIL: ML5_4909
MTUA: CSH63_07635(hppD)
MICH: FJK98_16440(hppD)
CAI: Caci_3256
HAU: Haur_1888
 » show all
Taxonomy
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2
  Authors
Choroba, O.W., Williams, D.H. and Spencer, J.B.
  Title
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.
  Journal
J Am Chem Soc 122:5389-5390 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.46
IUBMB Enzyme Nomenclature: 1.13.11.46
ExPASy - ENZYME nomenclature database: 1.13.11.46
BRENDA, the Enzyme Database: 1.13.11.46
CAS: 280566-04-3

KEGG   REACTION: R06632Help
Entry
R06632                      Reaction                               

Name
4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Definition
3-(4-Hydroxyphenyl)pyruvate + Oxygen <=> (S)-4-Hydroxymandelate + CO2
Equation
Reaction class
RC01471  C01179_C03198
Enzyme
Pathway
rn00261  Monobactam biosynthesis
rn01055  Biosynthesis of vancomycin group antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Orthology
K16421  4-hydroxymandelate synthase [EC:1.13.11.46]

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