KEGG   ORTHOLOGY: K16422
Entry
K16422                      KO                                     
Symbol
hmo, nocN
Name
4-hydroxymandelate oxidase [EC:1.1.3.46]
Pathway
map00261  Monobactam biosynthesis
map01055  Biosynthesis of vancomycin group antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06633  (S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.46  4-hydroxymandelate oxidase
     K16422  hmo, nocN; 4-hydroxymandelate oxidase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K16422  hmo, nocN; 4-hydroxymandelate oxidase
Genes
EBI: EbC_45010
EPI: Q3V30_00315
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PPHO: CTZ24_00375
PSUW: WQ53_04950
XBA: C7S18_07265
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PSET: THL1_1034
PALL: UYA_03960
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
AGU: AS4_05470
ABOU: ACBO_26740
SKH: STH12_02859(lldD)
PTU: PTUN_a4088(glcD)
AMAC: MASE_17490
PAT: Patl_2274
LFA: LFA_1216(GLO)
LHA: LHA_0501
CYQ: Q91_0345
GAI: IMCC3135_25780(hmo)
HCH: HCH_01681
TOL: TOL_2765
SALN: SALB1_1045
RME: Rmet_0839
CGD: CR3_3245(glcD)
BGU: KS03_3471
PUT: PT7_3646
AMIM: MIM_c24880
AFQ: AFA_02405
POL: Bpro_3049
PNA: Pnap_2560
AJS: Ajs_0513
ACRA: BSY15_3965
ACIQ: ACDW_28310
VEI: Veis_3083
DAC: Daci_4620
CTES: O987_18710
CTEZ: CT3_17380
RTA: Rta_24240
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
JAG: GJA_207(GLO5)
METR: BSY238_10
DSU: Dsui_1668
OTR: OTERR_15390(lldD)
AZO: azo0609(gox)
AOA: dqs_0678
THAU: C4PIVTH_1905(hmo)
MLO: mll4732
PLA: Plav_0378
NWI: Nwi_0702
TALZ: RPMA_16140
AZC: AZC_1619
SNO: Snov_2512
ASTD: ATDW_11230
KRO: BVG79_01849(glcD)
SINL: DSM14862_02055(hmo)
PDE: Pden_4676
HNE: HNE_2118
NAR: Saro_0774
SWI: Swit_4251
SSY: SLG_34570
HTL: HPTL_0509
ABU: Abu_0725
ABT: ABED_0676
AELL: AELL_0874
ASUI: ASUIS_0518
ACLO: ACLO_0849
DFL: DFE_2112
DMA: DMR_21260
DGG: DGI_1415
DDE: Dde_0750
DAS: Daes_2493
DVL: Dvul_0528
DBA: Dbac_1976
DPS: DP0843
DALK: DSCA_14510
DLI: dnl_38430
SCL: sce7671
HOH: Hoch_0089
LAD: LA14_1588
LAF: SD55_1597
LAM: LA2_08960
LKE: WANG_0215
CPE: CPE1878
CPF: CPF_2132
CPR: CPR_1844
CLS: CXIVA_13840(LldD)
CSQ: CSCA_4771
CACE: CACET_c16820(lldD)
HHW: NCTC503_02011(lldD)
CCE: Ccel_2344
FPR: FP2_21160
FPA: FPR_06650
DRM: Dred_1257
CTHM: CFE_0998
CSCI: HDCHBGLK_02317(hmo)
AOE: Clos_1159
PHX: KGNDJEFE_01524(hmo)
ADG: Adeg_1075
TSH: Tsac_2535
TOC: Toce_0633
KME: H0A61_01190(hmo)
MED: MELS_0352
PUF: UFO1_4337
STED: SPTER_33280(lldD)
AIN: Acin_0831
RHB: NY08_2291
TPR: Tpau_3076
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SMAL: SMALA_0360
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SALU: DC74_564
SALL: SAZ_03315
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
SRJ: SRO_7148
SAUH: SU9_002085
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NCA: Noca_1980
NDK: I601_3731(lldD_2)
NAQU: ENKNEFLB_02043(hmo)
NCX: Nocox_13260(noc1)
FAL: FRAAL3814
NML: Namu_3188
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
KRA: Krad_2981
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
AMYY: YIM_21185
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ASE: ACPL_2186
ACTS: ACWT_2064
SNA: Snas_1502
BTP: D805_1170
RXY: Rxyl_2999
BALA: DSM104299_02682(hmo)
SBAE: DSM104329_02733(hmo_2)
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
NSH: GXM_03321
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
SCYT: SAMD_31110
CTHE: Chro_0042
DGE: Dgeo_2057
DFC: DFI_08470
TRA: Trad_2342
TACI: TDSAC_1603
PBAP: Pla133_04810(mdlB)
BPW: WESB_0467
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
SLI: Slin_1817
AG: AAT09795(nocN) CAA11762(hmo)
 » show all
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3228]
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012
  Sequence

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