KEGG   ORTHOLOGY: K16422
Entry
K16422                      KO                                     

Name
hmo, nocN
Definition
4-hydroxymandelate oxidase [EC:1.1.3.46]
Pathway
ko00261  Monobactam biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.46  4-hydroxymandelate oxidase
     K16422  hmo, nocN; 4-hydroxymandelate oxidase
Other DBs
RN: R06633
Genes
EBI: EbC_45010
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PSUW: WQ53_04950
XBA: C7S18_07265
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PSET: THL1_1034
PALL: UYA_03960
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
AGU: AS4_05470
SKH: STH12_02859(lldD)
PTU: PTUN_a4088(glcD)
LFA: LFA_1216(GLO)
LHA: LHA_0501
GAI: IMCC3135_25780(hmo)
HCH: HCH_01681
SALN: SALB1_1045
CGD: CR3_3245(glcD)
BGU: KS03_3471
AFQ: AFA_02405
ACRA: BSY15_3965
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
METR: BSY238_10
OTR: OTERR_15390(lldD)
AOA: dqs_0678
AELL: AELL_0874
ASUI: ASUIS_0518
DVL: Dvul_0528
DDE: Dde_0750
DMA: DMR_21260
DGG: DGI_1415
DFL: DFE_2112
DAS: Daes_2493
DBA: Dbac_1976
DPS: DP0843
DALK: DSCA_14510
SCL: sce7671
HOH: Hoch_0089
PLA: Plav_0378
NWI: Nwi_0702
AZC: AZC_1619
PDE: Pden_4676
KRO: BVG79_01849(glcD)
NAR: Saro_0774
SWI: Swit_4251
HTL: HPTL_0509
LAD: LA14_1588
LAF: SD55_1597
LAM: LA2_08960
LKE: WANG_0215
CPE: CPE1878
CPF: CPF_2132
CPR: CPR_1844
CLS: CXIVA_13840(LldD)
CSQ: CSCA_4771
CACE: CACET_c16820(lldD)
AOE: Clos_1159
HHW: NCTC503_02011(lldD)
CCE: Ccel_2344
FPR: FP2_21160
FPA: FPR_06650
CSCI: HDCHBGLK_02317(hmo)
EHL: EHLA_0737
PHX: KGNDJEFE_01524(hmo)
DRM: Dred_1257
CTHM: CFE_0998
ADG: Adeg_1075
TSH: Tsac_2535
TACI: TDSAC_1603
TOC: Toce_0633
MED: MELS_0352
PUF: UFO1_4337
STED: SPTER_33280(lldD)
AIN: Acin_0831
RHB: NY08_2291
TPR: Tpau_3076
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SALU: DC74_564
SALL: SAZ_03315
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SMAL: SMALA_0360
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
SRJ: SRO_7148
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NCA: Noca_1980
NDK: I601_3731(lldD_2)
FAL: FRAAL3814
NML: Namu_3188
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
KRA: Krad_2981
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
AMYY: YIM_21185
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ACTS: ACWT_2064
SNA: Snas_1502
BTP: D805_1170
RXY: Rxyl_2999
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
NSH: GXM_03321
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
CTHE: Chro_0042
DGE: Dgeo_2057
DFC: DFI_08470
TRA: Trad_2342
BPW: WESB_0467
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
METH: MBMB1_1308
AG: AAT09795(nocN) CAA11762(hmo)
 » show all
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3228]
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012
  Sequence

KEGG   ENZYME: 1.1.3.46
Entry
EC 1.1.3.46                 Enzyme                                 

Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:R06633]
Reaction(KEGG)
R06633
Substrate
(S)-4-hydroxymandelate [CPD:C03198];
O2 [CPD:C00007]
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:C03590];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16422  4-hydroxymandelate oxidase
Genes
EBI: EbC_45010
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PSUW: WQ53_04950
XBA: C7S18_07265
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PSET: THL1_1034
PALL: UYA_03960
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
AGU: AS4_05470
SKH: STH12_02859(lldD)
PTU: PTUN_a4088(glcD)
LFA: LFA_1216(GLO)
LHA: LHA_0501
GAI: IMCC3135_25780(hmo)
HCH: HCH_01681
SALN: SALB1_1045
CGD: CR3_3245(glcD)
BGU: KS03_3471
AFQ: AFA_02405
ACRA: BSY15_3965
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
METR: BSY238_10
OTR: OTERR_15390(lldD)
AOA: dqs_0678
AELL: AELL_0874
ASUI: ASUIS_0518
DVL: Dvul_0528
DDE: Dde_0750
DMA: DMR_21260
DGG: DGI_1415
DFL: DFE_2112
DAS: Daes_2493
DBA: Dbac_1976
DPS: DP0843
DALK: DSCA_14510
SCL: sce7671
HOH: Hoch_0089
PLA: Plav_0378
NWI: Nwi_0702
AZC: AZC_1619
PDE: Pden_4676
KRO: BVG79_01849(glcD)
NAR: Saro_0774
SWI: Swit_4251
HTL: HPTL_0509
LAD: LA14_1588
LAF: SD55_1597
LAM: LA2_08960
LKE: WANG_0215
CPE: CPE1878
CPF: CPF_2132
CPR: CPR_1844
CLS: CXIVA_13840(LldD)
CSQ: CSCA_4771
CACE: CACET_c16820(lldD)
AOE: Clos_1159
HHW: NCTC503_02011(lldD)
CCE: Ccel_2344
FPR: FP2_21160
FPA: FPR_06650
CSCI: HDCHBGLK_02317(hmo)
EHL: EHLA_0737
PHX: KGNDJEFE_01524(hmo)
DRM: Dred_1257
CTHM: CFE_0998
ADG: Adeg_1075
TSH: Tsac_2535
TACI: TDSAC_1603
TOC: Toce_0633
MED: MELS_0352
PUF: UFO1_4337
STED: SPTER_33280(lldD)
AIN: Acin_0831
RHB: NY08_2291
TPR: Tpau_3076
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SALU: DC74_564
SALL: SAZ_03315
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SMAL: SMALA_0360
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
SRJ: SRO_7148
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NCA: Noca_1980
NDK: I601_3731(lldD_2)
FAL: FRAAL3814
NML: Namu_3188
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
KRA: Krad_2981
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
AMYY: YIM_21185
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ACTS: ACWT_2064
SNA: Snas_1502
BTP: D805_1170
RXY: Rxyl_2999
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
NSH: GXM_03321
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
CTHE: Chro_0042
DGE: Dgeo_2057
DFC: DFI_08470
TRA: Trad_2342
BPW: WESB_0467
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
METH: MBMB1_1308
 » show all
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2  [PMID:12240298]
  Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
  Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
  Journal
Chem Commun (Camb) 1752-3 (2001)
DOI:10.1039/b103548g
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.46
IUBMB Enzyme Nomenclature: 1.1.3.46
ExPASy - ENZYME nomenclature database: 1.1.3.46
BRENDA, the Enzyme Database: 1.1.3.46

KEGG   REACTION: R06633
Entry
R06633                      Reaction                               

Name
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Definition
(S)-4-Hydroxymandelate + Oxygen <=> 4-Hydroxyphenylglyoxylate + Hydrogen peroxide
Equation
Reaction class
RC00240  C03198_C03590
RC02755  C00007_C00027
Enzyme
Pathway
rn00261  Monobactam biosynthesis
rn01055  Biosynthesis of vancomycin group antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16422  4-hydroxymandelate oxidase [EC:1.1.3.46]
Other DBs
RHEA: 41230

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