KEGG   ORTHOLOGY: K16422Help
Entry
K16422                      KO                                     

Name
hmo, nocN
Definition
4-hydroxymandelate oxidase [EC:1.1.3.46]
Pathway
ko00261  Monobactam biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16422  hmo, nocN; 4-hydroxymandelate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.46  4-hydroxymandelate oxidase
     K16422  hmo, nocN; 4-hydroxymandelate oxidase
BRITE hierarchy
Other DBs
RN: R06633
Genes
EBI: EbC_45010
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PSUW: WQ53_04950
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PSET: THL1_1034
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
PTU: PTUN_a4088(glcD)
LHA: LHA_0501
GAI: IMCC3135_25780(hmo)
SALN: SALB1_1045
CGD: CR3_3245(glcD)
BGU: KS03_3471
AFQ: AFA_02405
ACRA: BSY15_3965
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
OTR: OTERR_15390(lldD)
AOA: dqs_0678
SCL: sce7671
HOH: Hoch_0089
PLA: Plav_0378
NWI: Nwi_0702
AZC: AZC_1619
PDE: Pden_4676
KVL: KVU_2484
HTL: HPTL_0509
RHB: NY08_2291
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SALU: DC74_564
SALL: SAZ_03315
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SMAL: SMALA_0360
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NDK: I601_3731(lldD_2)
KFL: Kfla_6052
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ACTS: ACWT_2064
BTP: D805_1170
RXY: Rxyl_2999
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
CTHE: Chro_0042
HAU: Haur_1871
DGE: Dgeo_2057
DFC: DFI_08470
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
AG: CAA11762(hmo)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3228]

KEGG   ENZYME: 1.1.3.46Help
Entry
EC 1.1.3.46                 Enzyme                                 

Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:R06633]
Reaction(KEGG)
Substrate
(S)-4-hydroxymandelate [CPD:C03198];
O2 [CPD:C00007]
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:C03590];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K16422  4-hydroxymandelate oxidase
Genes
EBI: EbC_45010
PAO: Pat9b_0059
KLN: LH22_02000
PANS: FCN45_00295
PSUW: WQ53_04950
PMY: Pmen_0804
PRE: PCA10_09820(lldD)
PPSE: BN5_0696(glcD3)
PSET: THL1_1034
AVN: Avin_12350(lldD)
AVL: AvCA_12350(lldD)
AVD: AvCA6_12350(lldD)
ACX: Achr_30250(lldD)
PTU: PTUN_a4088(glcD)
LHA: LHA_0501
GAI: IMCC3135_25780(hmo)
SALN: SALB1_1045
CGD: CR3_3245(glcD)
BGU: KS03_3471
AFQ: AFA_02405
ACRA: BSY15_3965
LIH: L63ED372_01067(lldD_1)
HYB: Q5W_00125
HPSE: HPF_09820
RGE: RGE_43910
OTR: OTERR_15390(lldD)
AOA: dqs_0678
SCL: sce7671
HOH: Hoch_0089
PLA: Plav_0378
NWI: Nwi_0702
AZC: AZC_1619
PDE: Pden_4676
KVL: KVU_2484
HTL: HPTL_0509
RHB: NY08_2291
SCO: SCO3228(SCE63.05)
SGB: WQO_12235
SHY: SHJG_8441
SALU: DC74_564
SALL: SAZ_03315
STRE: GZL_08686
SRW: TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SMAL: SMALA_0360
SLAU: SLA_6885
SALF: SMD44_00061(glcD)
LMOI: VV02_16505
CFL: Cfla_2130
SERJ: SGUI_0332
NDK: I601_3731(lldD_2)
KFL: Kfla_6052
BSD: BLASA_0395(Hao) BLASA_2148(hao2)
MMAR: MODMU_3504(Hao)
AMD: AMED_0893
AMN: RAM_04555
AMM: AMES_0890
AMZ: B737_0891
AOI: AORI_1496(glcD)
KAL: KALB_6131
ACTI: UA75_15340
ACAD: UA74_14770
MIL: ML5_4923
ACTS: ACWT_2064
BTP: D805_1170
RXY: Rxyl_2999
HHG: XM38_038450(hmo)
CYT: cce_1717
TER: Tery_2398
ANA: all0170
AVA: Ava_1430
CALH: IJ00_16930
DOU: BMF77_03099(hmo)
CTHE: Chro_0042
HAU: Haur_1871
DGE: Dgeo_2057
DFC: DFI_08470
ABAS: ACPOL_6814
ABAC: LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: GAU_0248
 » show all
Taxonomy
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2  [PMID:12240298]
  Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
  Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
  Journal
Chem Commun (Camb) 1752-3 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.46
IUBMB Enzyme Nomenclature: 1.1.3.46
ExPASy - ENZYME nomenclature database: 1.1.3.46
BRENDA, the Enzyme Database: 1.1.3.46

KEGG   REACTION: R06633Help
Entry
R06633                      Reaction                               

Name
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Definition
(S)-4-Hydroxymandelate + Oxygen <=> 4-Hydroxyphenylglyoxylate + Hydrogen peroxide
Equation
Reaction class
RC00240  C03198_C03590
RC02755  C00007_C00027
Enzyme
Pathway
rn00261  Monobactam biosynthesis
rn01055  Biosynthesis of vancomycin group antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Orthology
K16422  4-hydroxymandelate oxidase [EC:1.1.3.46]
Other DBs
RHEA: 41230

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