KEGG   ORTHOLOGY: K16423Help
Entry
K16423                      KO                                     

Name
hpgT, nocG
Definition
(S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
Pathway
ko00261  Monobactam biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16423  hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16423  hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.103  (S)-3,5-dihydroxyphenylglycine transaminase
     K16423  hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase
BRITE hierarchy
Other DBs
RN: R06626 R06634
Genes
SMAF: D781_2332
SERM: CLM71_12105
DDA: Dd703_3064
PLU: plu1105
PLUM: A4R40_05450
XAL: XALC_1062
XTN: FD63_09735 FD63_09805
PFE: PSF113_4198
PBA: PSEBR_a4101
PBC: CD58_21635
HCH: HCH_01676
BGU: KS03_3097
BGO: BM43_2883
SCO: SCO3227(SCE63.06)
SBH: SBI_01124
SHY: SHJG_1205
SALS: SLNWT_0925
SALU: DC74_566
SALL: SAZ_03325
STRE: GZL_08684
SMAL: SMALA_7754
SLAU: SLA_6886
SFK: KY5_6710c
KFL: Kfla_6051
NDA: Ndas_1742
NAL: B005_2520
AMI: Amir_4591
ACTI: UA75_15375
ACAD: UA74_14805
SAQ: Sare_2660
MIL: ML5_4924
CAI: Caci_3266
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3227]

KEGG   ENZYME: 2.6.1.103Help
Entry
EC 2.6.1.103                Enzyme                                 

Name
(S)-3,5-dihydroxyphenylglycine transaminase;
HpgT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate [RN:R06634]
Reaction(KEGG)
R06634;
(other) R06626
Show
Substrate
(S)-3,5-dihydroxyphenylglycine [CPD:C12026];
2-oxoglutarate [CPD:C00026]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.6.1.103 created 2013
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K16423  (S)-3,5-dihydroxyphenylglycine transaminase
Genes
SMAF: D781_2332
SERM: CLM71_12105
DDA: Dd703_3064
PLU: plu1105
PLUM: A4R40_05450
XAL: XALC_1062
XTN: FD63_09735 FD63_09805
PFE: PSF113_4198
PBA: PSEBR_a4101
PBC: CD58_21635
HCH: HCH_01676
BGU: KS03_3097
BGO: BM43_2883
SCO: SCO3227(SCE63.06)
SBH: SBI_01124
SHY: SHJG_1205
SALS: SLNWT_0925
SALU: DC74_566
SALL: SAZ_03325
STRE: GZL_08684
SMAL: SMALA_7754
SLAU: SLA_6886
SFK: KY5_6710c
KFL: Kfla_6051
NDA: Ndas_1742
NAL: B005_2520
AMI: Amir_4591
ACTI: UA75_15375
ACAD: UA74_14805
SAQ: Sare_2660
MIL: ML5_4924
CAI: Caci_3266
 » show all
Taxonomy
Reference
1
  Authors
Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.
  Title
Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.
  Journal
Chem Comm:1252-1253 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.103
IUBMB Enzyme Nomenclature: 2.6.1.103
ExPASy - ENZYME nomenclature database: 2.6.1.103
BRENDA, the Enzyme Database: 2.6.1.103

KEGG   REACTION: R06634Help
Entry
R06634                      Reaction                               

Name
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Definition
3,5-Dihydroxy-phenylglycine + 2-Oxoglutarate <=> 3,5-Dihydroxyphenylglyoxylate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026
RC01104  C12026_C12325
Enzyme
Pathway
rn01055  Biosynthesis of vancomycin group antibiotics
rn01130  Biosynthesis of antibiotics
Orthology
K16423  (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
Other DBs
RHEA: 38350

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