KEGG   ORTHOLOGY: K16427Help
Entry
K16427                      KO                                     

Name
dpgC
Definition
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
Pathway
ko01055  Biosynthesis of vancomycin group antibiotics
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16427  dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.80  (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
     K16427  dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
BRITE hierarchy
Other DBs
RN: R06624
COG: COG1024
Genes
SMAF: D781_2329
XAL: XALC_1061
XTN: FD63_09800
NBR: O3I_032810
NTP: CRH09_30860
SVE: SVEN_0495
SRC: M271_00275 M271_09135
SCW: TU94_04895
STRC: AA958_31875
SPRI: SPRI_0192 SPRI_7161
SFK: KY5_7442
KFL: Kfla_4130
NDA: Ndas_1737
SESP: BN6_47880
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1504]

KEGG   ENZYME: 1.13.11.80Help
Entry
EC 1.13.11.80               Enzyme                                 

Name
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase;
DpgC
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
(3,5-dihydroxyphenyl)acetyl-CoA:oxygen oxidoreductase
Reaction(IUBMB)
(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA [RN:R06624]
Reaction(KEGG)
Substrate
3,5-dihydroxyphenylacetyl-CoA [CPD:C12324];
O2 [CPD:C00007]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
CoA [CPD:C00010]
Comment
The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin.
History
EC 1.13.11.80 created 2015
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
ec01130  Biosynthesis of antibiotics
Orthology
K16427  (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
Genes
SMAF: D781_2329
XAL: XALC_1061
XTN: FD63_09800
NBR: O3I_032810
NTP: CRH09_30860
SVE: SVEN_0495
SRC: M271_00275 M271_09135
SCW: TU94_04895
STRC: AA958_31875
SPRI: SPRI_0192 SPRI_7161
SFK: KY5_7442
KFL: Kfla_4130
NDA: Ndas_1737
SESP: BN6_47880
 » show all
Taxonomy
Reference
1  [PMID:11752437]
  Authors
Chen H, Tseng CC, Hubbard BK, Walsh CT
  Title
Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.
  Journal
Proc Natl Acad Sci U S A 98:14901-6 (2001)
DOI:10.1073/pnas.221582098
Reference
2  [PMID:17507985]
  Authors
Widboom PF, Fielding EN, Liu Y, Bruner SD.
  Title
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.
  Journal
Nature 447:342-5 (2007)
DOI:10.1038/nature05702
Reference
3  [PMID:18004875]
  Authors
Fielding EN, Widboom PF, Bruner SD
  Title
Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC.
  Journal
Biochemistry 46:13994-4000 (2007)
DOI:10.1021/bi701148b
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.80
IUBMB Enzyme Nomenclature: 1.13.11.80
ExPASy - ENZYME nomenclature database: 1.13.11.80
BRENDA, the Enzyme Database: 1.13.11.80

KEGG   REACTION: R06624Help
Entry
R06624                      Reaction                               

Name
3,5-dihydroxyphenylacetyl-CoA:oxygen oxidoreductase (3,5-dihydroxyphenylglyoxylate-forming)
Definition
3,5-Dihydroxyphenylacetyl-CoA + Oxygen <=> 3,5-Dihydroxyphenylglyoxylate + CoA
Equation
Comment
cofactor-independent dioxygenase,DpgC
Reaction class
RC00004  C00010_C12324
RC01655  C12324_C12325
Enzyme
Pathway
rn01055  Biosynthesis of vancomycin group antibiotics
rn01130  Biosynthesis of antibiotics
Orthology
K16427  (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
Other DBs
RHEA: 44635

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