KEGG ORTHOLOGY: K16431

ORTHOLOGY: K16431

Entry

K16431                      KO

Symbol

cepH, sgcC3, mdpC3, kedY3

Name

FAD-dependent halogenase [EC:1.14.19.-]

Pathway

map01055

Biosynthesis of vancomycin group antibiotics

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00827

C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP

M00832

Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP

Reaction

R11368

(S)-beta-tyrosyl-[pcp]:FADH2 oxidoreductase

R11393

(R)-2-aza-beta-tyrosyl-[pcp]:FADH2 oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
   01055 Biosynthesis of vancomycin group antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Halogenase
   K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase

Other DBs

COG:

COG0644

Genes

PPII:

QL104_15920(cmlS)

SCU:	SCE1572_25035

CCRO:

CMC5_053240 CMC5_053840

PAUU:

E8A73_042155

NANN:

O0S08_10660

MBAI:

MB901379_01065

NTP:	CRH09_30915

NOZ:	DMB37_37155

GPO:	GPOL_c23630

GOM:	D7316_00962(lodB)

GOI:	LK459_21680

SGB:

WQO_33760

SGRF:

SGFS_011860

SRC:	M271_00350 M271_09130

SMAL:

SSOI:

SBH:

STRE:

SPAV:

STRT:

SALW:

CP975_22835 CP975_34455

SLS:	SLINC_7264

SPLU:

LK06_002690

SFK:

KY5_1050c

SCYA:

EJ357_01705 EJ357_41000

SVR:	CP971_08125

SAQU:

EJC51_07485

SRIM:

CP984_06525

SFUG:

CNQ36_25600

SCHA:

CP983_01470 CP983_41755

SCOE:

CP976_03650

SCYG:

S1361_05250(lodB2_1)

SDUR:

SAKB:

SSPN:

SYUN:

SJN:	RI060_39175

SKG:	KJK29_36055

SCOA:

QU709_04175

KBU:	Q4V64_49195

SLUO:

PS467_34870

KCH:	O1G21_34350 O1G21_34360

STRR:

EKD16_14345(lodB)

AMAZ:

LUW76_44530 LUW76_44640

NOA:	BKM31_54195

NCX:	Nocox_13395(noc24)

NGN:	LCN96_07830

FRA:	Francci3_2465

AOI:	AORI_1485 AORI_5364

AJA:	AJAP_16200 AJAP_22795

AMYY:

YIM_16050(lodB)

AORI:

SD37_16625 SD37_23460 SD37_33695

AROO:

NQK81_11520

KUT:	JJ691_30220

ACTI:

ACAD:

ACTA:

SAQ:

MICF:

AMS:	AMIS_32430

ACTR:

Asp14428_14200

ACTL:

L3i22_035490

AOU:	ACTOB_006402 ACTOB_006470 ACTOB_006472

PLK:	CIK06_16755

DVC:	Dvina_18580

DFU:	Dfulv_14710

AG:	ABY66006(mdpC3) AFV52210(kedY3)

» show all

Reference

PMID:24884615

Authors

Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W

Title

Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

Journal

BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363

Sequence

[aoi:AORI_1485]

Reference

PMID:17887753

Authors

Lin S, Van Lanen SG, Shen B

Title

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

J Am Chem Soc 129:12432-8 (2007)
DOI:10.1021/ja072311g

Reference

PMID:12183628 (sgcC3)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33760]

All links

Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (10)   
   KEGG PATHWAY (8)   
   KEGG MODULE (2)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (259)   
   KEGG GENES (81)   
   KEGG MGENES (177)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (279)   

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