KEGG   ORTHOLOGY: K16431
Entry
K16431                      KO                                     
Symbol
cepH, sgcC3, mdpC3, kedY3
Name
FAD-dependent halogenase [EC:1.14.19.-]
Pathway
map01055  Biosynthesis of vancomycin group antibiotics
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00832  Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
   01055 Biosynthesis of vancomycin group antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.-
     K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Halogenase
   K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Other DBs
RN: R11368 R11393
COG: COG0644
Genes
SCU: SCE1572_25035
CCRO: CMC5_053240 CMC5_053840
PAUU: E8A73_042155
NANN: O0S08_10660
MBAI: MB901379_01065
NTP: CRH09_30915
NOZ: DMB37_37155
GPO: GPOL_c23630
GOM: D7316_00962(lodB)
GOI: LK459_21680
SGB: WQO_33760
SMAL: SMALA_7763
SBH: SBI_00676
STRE: GZL_07290
SFK: KY5_1050c
SCYG: S1361_05250(lodB2_1)
STRR: EKD16_14345(lodB)
NCX: Nocox_13395(noc24)
AMYY: YIM_16050(lodB)
ACTI: UA75_18105
ACAD: UA74_17580
SAQ: Sare_2119
AG: ABY66006(mdpC3) AFV52210(kedY3)
 » show all
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1485]
Reference
  Authors
Lin S, Van Lanen SG, Shen B
  Title
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Am Chem Soc 129:12432-8 (2007)
DOI:10.1021/ja072311g
Reference
PMID:12183628 (sgcC3)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33760]

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