KEGG   ORTHOLOGY: K16438
Entry
K16438                      KO                                     

Name
evaD, eryBVII, aveBV, megDIV, staE
Definition
5-epimerase [EC:5.1.3.-]
Pathway
ko00404  Staurosporine biosynthesis
ko00523  Polyketide sugar unit biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00798  dTDP-L-mycarose biosynthesis
M00799  dTDP-L-oleandrose biosynthesis
M00800  dTDP-L-megosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
   01055 Biosynthesis of vancomycin group antibiotics
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.-  
     K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
Other DBs
RN: R06433 R06628 R08934 R11046 R11138
Genes
NBR: O3I_007430
NTP: CRH09_07945
SALB: XNR_0573
SMA: SAVERM_949(aveBV)
SGR: SGR_629
SVE: SVEN_5999
SALU: DC74_6613
SALL: SAZ_34380
SLD: T261_6856
SXI: SXIM_35750
SLE: sle_09270(sle_09270)
SRN: A4G23_02283(rmlC) A4G23_02292(gerF)
SNR: SNOUR_10130(eryBVII)
SALF: SMD44_08279(rfbC)
STRR: EKD16_15530(novW)
TCU: Tcur_2791
SEN: SACE_0714(eryBVII)
SACC: EYD13_17005(rmlC)
AMD: AMED_7962(rfbC)
AMN: RAM_40920
AMM: AMES_7844(rfbC)
AMZ: B737_7844(rfbC)
AOI: AORI_1501(rfbC)
AJA: AJAP_32015(staE)
AMQ: AMETH_5764(rfbC)
AMYY: YIM_05675(novW) YIM_08365(rmlC1)
AMI: Amir_6280
SESP: BN6_75510(rfbC3)
KAL: KALB_6583(acuS3)
ACAD: UA74_05665
AHG: AHOG_05430(novW1)
ALO: CRK59671
MIL: ML5_4416
MCAB: HXZ27_04133(evdS13)
AG: AAG13911(megDIV) BAC55217(staE)
 » show all
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1501]
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0714]
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
DOI:10.1016/S1074-5521(01)00043-6
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
Reference
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
  Sequence

KEGG   REACTION: R11046
Entry
R11046                      Reaction                               

Name
dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose 5-epimerase
Definition
dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose
Equation
Reaction class
RC01518  C21073_C21074
Enzyme
5.1.3.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00800  dTDP-L-megosamine biosynthesis
Orthology
K16438  5-epimerase [EC:5.1.3.-]

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