KEGG   ORTHOLOGY: K16438
Entry
K16438                      KO                                     

Name
evaD, eryBVII, aveBV, megDIV, staE
Definition
5-epimerase [EC:5.1.3.-]
Pathway
ko00404  Staurosporine biosynthesis
ko00523  Polyketide sugar unit biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00798  dTDP-L-mycarose biosynthesis
M00799  dTDP-L-oleandrose biosynthesis
M00800  dTDP-L-megosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
   01055 Biosynthesis of vancomycin group antibiotics
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.-  
     K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
Other DBs
RN: R06433 R06628 R08934 R11046 R11138
Genes
NBR: O3I_007430
NTP: CRH09_07945
SALB: XNR_0573
SMA: SAVERM_949(aveBV)
SGR: SGR_629
SVE: SVEN_5999
SALU: DC74_6613
SALL: SAZ_34380
SLD: T261_6856
SXI: SXIM_35750
SPRI: SPRI_0240 SPRI_7113
SLE: sle_09270(sle_09270)
SRN: A4G23_02283(rmlC) A4G23_02292(gerF)
SCLF: BB341_29645
SNR: SNOUR_10130(eryBVII)
SPUN: BFF78_11210
SALF: SMD44_08279(rfbC)
SGD: ELQ87_08070
STIR: DDW44_27805
SKA: CP970_39805
SFIC: EIZ62_04030 EIZ62_09595
SGAL: CP966_29045
SSPO: DDQ41_30665
SPAD: DVK44_01720
SGF: HEP81_07923
AER: AERYTH_15830
NGV: CDO52_02805
STRR: EKD16_15530(novW)
TCU: Tcur_2791
NOW: GBF35_40095
SEN: SACE_0714(eryBVII)
SACE: GIY23_18560
SACG: FDZ84_06960
SVI: Svir_30640
SACC: EYD13_17005(rmlC)
AMD: AMED_7962(rfbC)
AMN: RAM_40920
AMM: AMES_7844(rfbC)
AMZ: B737_7844(rfbC)
AOI: AORI_1501(rfbC)
AJA: AJAP_32015(staE)
AMQ: AMETH_5764(rfbC)
AMYC: CU254_32330
AMYB: BKN51_41545
AAB: A4R43_01820 A4R43_23095
AMYY: YIM_05675(novW) YIM_08365(rmlC1)
AORI: SD37_06785 SD37_33615
PSEQ: AD006_30045
PECQ: AD017_31205
APRE: CNX65_30930
AMI: Amir_6280
SESP: BN6_75510(rfbC3)
SSYI: EKG83_32245 EKG83_42105
KAL: KALB_6583(acuS3)
KPHY: AOZ06_22540 AOZ06_23380
LED: BBK82_19555 BBK82_43755
AHM: TL08_05630
ACTI: UA75_05670 UA75_16855
ACAD: UA74_05665
AHG: AHOG_05430(novW1)
ACTA: C1701_01565 C1701_14905
ALO: CRK59671
PMAD: BAY61_07765
STP: Strop_2217
SAQ: Sare_2018 Sare_2338
MAU: Micau_4005
MIL: ML5_4416
MCAB: HXZ27_04133(evdS13)
AMS: AMIS_50610
AEY: CDG81_13220
EKE: EK0264_16180
AG: AAG13911(megDIV) BAC55217(staE)
 » show all
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1501]
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0714]
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
DOI:10.1016/S1074-5521(01)00043-6
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
Reference
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
  Sequence

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical reaction (6)   
   KEGG REACTION (5)   
   KEGG RCLASS (1)   
Gene (92)   
   KEGG GENES (84)   
   RefGene (7)   
   OC (1)   
Literature (5)   
   PubMed (5)   
All databases (118)   

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KEGG   REACTION: R11138
Entry
R11138                      Reaction                               

Definition
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose
Equation
Comment
unclear reaction
Reaction class
RC01518  C12318_C21137
Pathway
rn00404  Staurosporine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K16438  5-epimerase [EC:5.1.3.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (1)   
   KEGG RCLASS (1)   
Gene (85)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (84)   
All databases (93)   

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