KEGG ORTHOLOGY: K16669

ORTHOLOGY: K16669

Entry

K16669                      KO

Symbol

FAT4

Name

protocadherin Fat 4

Pathway

map04391

Hippo signaling pathway - fly

map04392

Hippo signaling pathway - multiple species

Disease

H01393

Van Maldergem syndrome

H02169

Hennekam lymphangiectasia-lymphedema syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04391 Hippo signaling pathway - fly
    K16669  FAT4; protocadherin Fat 4
   04392 Hippo signaling pathway - multiple species
    K16669  FAT4; protocadherin Fat 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules
    K16669  FAT4; protocadherin Fat 4
Cell adhesion molecules [BR:ko04515]
Cadherins
  Cadherin related
   K16669  FAT4; protocadherin Fat 4

Genes

HSA:	79633(FAT4)

PTR:	471300(FAT4)

PPS:	100981077(FAT4)

GGO:	101140356(FAT4)

PON:	100461224(FAT4)

PPYG:

129035469(FAT4)

NLE:	100595864(FAT4)

HMH:	116463664(FAT4)

SSYN:

129480643(FAT4)

MCC:	711867(FAT4)

MCF:	102139504(FAT4)

MTHB:

126955619

MNI:	105486113(FAT4)

CSAB:

103236229(FAT4)

CATY:

105595806(FAT4)

PANU:

101007655(FAT4)

TGE:	112624930(FAT4)

MLEU:

105538393(FAT4)

RRO:	104656717(FAT4)

RBB:	108539274(FAT4)

TFN:	117085886(FAT4)

PTEH:

111546274(FAT4)

CANG:

105516428(FAT4)

CJC:	100398546(FAT4)

SBQ:	101035363(FAT4)

CIMI:

108314041(FAT4)

ANAN:

105731352(FAT4)

CSYR:

103250009(FAT4)

MMUR:

105882088(FAT4)

LCAT:

123638588(FAT4)

PCOQ:

105810231(FAT4)

OGA:	100944222(FAT4)

MMU:	329628(Fat4)

MCAL:

110291362(Fat4)

MPAH:

110319952(Fat4)

RNO:	310341(Fat4)

MCOC:

116095127(Fat4)

ANU:	117707125(Fat4)

MUN:	110545882(Fat4)

CGE:	100769423(Fat4)

MAUA:

101833146(Fat4)

PROB:

127223178(Fat4)

PLEU:

114681872(Fat4) 114689127

MORG:

121452855(Fat4)

MFOT:

126499274

AAMP:

119826626(Fat4)

NGI:	103731944 103734692

HGL:	101696655(Fat4)

CPOC:

100722846(Fat4)

CCAN:

109702764(Fat4)

DORD:

105989862(Fat4)

DSP:

122098180

PLOP:

125341362(Fat4)

NCAR:

124994424

MMMA:

107136577(Fat4)

OCU:

100358710

OPI:	101529375(FAT4)

TUP:	102486195(FAT4)

GVR:

103597192

CFA:	483834(FAT4)

CLUD:

112642767(FAT4)

VVP:	112933624(FAT4)

VLG:	121493056(FAT4)

NPO:	129504359(FAT4)

AML:	100477718(FAT4)

UMR:	103656997(FAT4)

UAH:	113255648(FAT4)

UAR:	123793300(FAT4)

ELK:

111156127

LLV:

125093368

MPUF:

101692124(FAT4)

MNP:	132002902(FAT4)

MLK:	131828068(FAT4)

NVS:	122889128(FAT4)

ORO:	101367799(FAT4)

EJU:	114208252(FAT4)

ZCA:	113924903(FAT4)

MLX:	118022342(FAT4)

NSU:	110573022(FAT4)

LWW:	102738819(FAT4)

FCA:	101085714(FAT4)

PYU:	121029924(FAT4)

PCOO:

112858296(FAT4)

PBG:	122476320(FAT4)

PVIV:

125164204(FAT4)

LRUF:

124521002

PTG:	102953324(FAT4)

PPAD:

109249030(FAT4)

PUC:

125923102

AJU:

106978941

HHV:	120245820(FAT4)

BTA:	781683(FAT4)

BOM:	102286968(FAT4)

BIU:	109571248(FAT4)

BBUB:

102399183(FAT4)

BBIS:

104996381 105003224(FAT4)

CHX:	102179034(FAT4)

OAS:	101123237(FAT4)

BTAX:

128062356(FAT4)

ODA:	120870971(FAT4)

CCAD:

122452967(FAT4)

MBEZ:

129542906(FAT4)

SSC:	100622618(FAT4)

CFR:	102517089(FAT4)

CBAI:

105067150(FAT4)

CDK:	105087054(FAT4)

VPC:	102538524(FAT4)

BACU:

103010363 103013318(FAT4)

BMUS:

118895514(FAT4)

LVE:	103090950(FAT4)

OOR:	101277484(FAT4)

DLE:	111186067(FAT4)

PCAD:

102983297(FAT4)

PSIU:

116754190(FAT4)

NASI:

112399793(FAT4)

ECB:	100063659(FAT4)

EPZ:	103550700 103550704 103558457 103559938(FAT4)

EAI:	106825472(FAT4)

MYB:	102240052(FAT4)

MYD:	102762255(FAT4)

MMYO:

118658370(FAT4)

MLF:	102435565(FAT4)

MDT:	132235548(FAT4)

PKL:	118710942(FAT4)

EFUS:

103287635(FAT4)

MNA:	107529801(FAT4)

DRO:	112312453(FAT4)

SHON:

118995478(FAT4)

AJM:	119037606(FAT4)

PDIC:

114504002(FAT4)

PHAS:

123813692(FAT4)

MMF:	118615728(FAT4)

PPAM:

129062394(FAT4)

HAI:	109374082(FAT4)

RFQ:	117037601(FAT4)

PALE:

102884681(FAT4)

PGIG:

120616238(FAT4)

PVP:	105302714(FAT4)

RAY:	107518502(FAT4)

MJV:	108385864(FAT4)

TOD:	119234787(FAT4)

SARA:

101554561(FAT4)

SETR:

126004452(FAT4)

LAV:	100673183(FAT4)

TMU:

101340661

ETF:	101660710(FAT4)

DNM:	101416826(FAT4)

MDO:	100014833(FAT4)

GAS:	123252961(FAT4)

SHR:	100932038(FAT4)

AFZ:

127541478

PCW:	110222980(FAT4)

TVP:	118853608(FAT4)

OAA:	103169602(FAT4)

GGA:	395166(FAT4)

PCOC:

116231288(FAT4)

MGP:	100549770(FAT4)

CJO:	107313558(FAT4)

TPAI:

128080612(FAT4)

LMUT:

125692003(FAT4)

NMEL:

110398068(FAT4)

APLA:

101798607(FAT4)

ACYG:

106042424(FAT4)

CATA:

118252045(FAT4)

AFUL:

116488837(FAT4)

TGU:	100222872(FAT4)

LSR:	110484366(FAT4)

SCAN:

103821438(FAT4)

PMOA:

120500690 120507565 120508619(FAT4)

OTC:	121339805(FAT4)

PRUF:

121361527(FAT4) 121365470

GFR:	102034981 102038604(PCDHGA12) 102039384

FAB:	101806425(FAT4)

OMA:	130252460(FAT4) 130258913

PHI:	102107078(FAT4)

PMAJ:

107203439(FAT4)

CCAE:

111929083(FAT4)

CCW:	104693716(FAT4) 104696062

CBRC:

103614987 103617458(FAT4)

ETL:	114061107(FAT4) 114063200 114071191

ZAB:	102068982(FAT4)

ZLE:	135446968(FAT4)

ACHL:

103799253(FAT4)

SVG:	106857550(FAT4)

MMEA:

130577731(FAT4) 130585197

HRT:	120752635(FAT4)

SATI:

136360028(FAT4)

FPG:	101924002(FAT4)

FCH:	102058439(FAT4)

CCRI:

104168975(FAT4)

NNT:

104408328

SHAB:

115605524(FAT4)

ACUN:

113479634(FAT4)

TALA:

104357334(FAT4)

ACHC:

115344026(FAT4)

HLE:	104836863(FAT4) 104839138

AGEN:

126044879

GCL:

127015399

CSTI:

104554194(FAT4)

LDI:	104350992(FAT4)

MNB:	103771389(FAT4)

DPUB:

104296223(FAT4) 104299838 104301314 104309060

AVIT:

104280474

BRHI:

104500081(FAT4)

EGZ:	104129314(FAT4) 104129315 104135801(PCDHGC3)

NNI:	104015970(FAT4)

PCAO:

104052986

PADL:

103921967 103926143(FAT4)

AFOR:

103907350(FAT4)

FGA:	104074502(FAT4)

GSTE:

104255345(FAT4)

CLV:	102087034 102093311(FAT4)

MUI:	104541709(FAT4)

PGUU:

104463086(FAT4)

PLET:

104622237(FAT4)

EHS:	104509077(FAT4)

CUCA:

104063926(FAT4)

TEO:	104381053(FAT4)

BREG:

104643900

OHA:	104338342 104339590(FAT4)

ACAR:

104523971(FAT4)

CPEA:

104398820(FAT4)

CVF:	104282627 104283262

RTD:	128910010(FAT4)

AAM:	106491849(FAT4)

AROW:

112973483(FAT4)

NPD:	112958164(FAT4)

DNE:	112996802(FAT4)

SCAM:

104149665(FAT4)

ASN:	102386106(FAT4)

AMJ:	102563417(FAT4)

CPOO:

109309340(FAT4)

GGN:	109300936(FAT4)

PSS:	102463581 102463734

CMY:	102941172(FAT4)

CCAY:

125635519(FAT4)

DCC:	119854571(FAT4)

CPIC:

101938961(FAT4)

TST:	117878339(FAT4)

CABI:

116820234 116821652(FAT4)

MRV:	120406008(FAT4)

ACS:	100558090(fat4)

ASAO:

132776865(FAT4)

PVT:	110072841(FAT4)

SUND:

121931134(FAT4)

PBI:	103057105 103068079(FAT4)

PMUR:

107283624 107289846(FAT4) 107299354

CTIG:

120300278 120300282 120300283 120313475(FAT4)

TSR:	106540532(FAT4) 106552518

PGUT:

117680243(FAT4)

APRI:

131194992 131194996 131203056(FAT4)

PTEX:

113434705(FAT4) 113436464 113448142(PCDHGC5)

NSS:	113411794(FAT4) 113422329(PCDHGC5)

VKO:	123022604(FAT4)

PMUA:

114604466(FAT4)

PRAF:

128421129(FAT4)

ZVI:	118079395 118083358(FAT4)

HCG:	128326974(FAT4)

GJA:	107108907(FAT4)

STOW:

125439697(FAT4)

EMC:	129336619(FAT4)

XLA:	108706693(fat4.S) 108710139(fat4.L)

XTR:	100145590(fat4)

NPR:	108786384(FAT4)

RTEM:

120918818(FAT4)

BBUF:

120989957(FAT4)

BGAR:

122944043(FAT4)

MUO:	115461719(FAT4) 115476829 115476840

GSH:	117351846 117357739(FAT4)

DRE:	101882648(fat4) 101883589 108191529

SRX:	107712913(fat4) 107717300 107746699 107757384

SANH:

107683444 107694441 107704460 107704705

SGH:	107557620 107557622 107559001 107568664(fat4) 107587941

CCAR:

109053720 109071426 109101772 109101775

CAUA:

113058634 113076232 113114357

CGIB:

127971415 128027404 128028822

PTET:

122333608 122359585

LROH:

127176253 127176932

OMC:	131553260(fat4) 131554036

PPRM:

120465292 120478764

RKG:	130082725 130082762 130105806

MAMB:

125261514

CIDE:

127494195

CERY:

137004193 137026643(fat4) 137034717

MASI:

127412743 127418062

TROS:

130565286

TDW:	130428172 130438026(fat4)

MANU:

129421888(fat4) 129438227

IPU:	108256470 108277553

IFU:

128623049

PHYP:

113528637(fat4) 113539399

SMEO:

124393520 124396608

TFD:	113649404 113650345 113659152

TVC:	132860599(fat4)

TRN:	134332489 134332889 134332894 134336040(fat4)

AMEX:

103022204 103037566

CMAO:

118804675 118820919

EEE:	113568421 113575575 113589027

CHAR:

105906534

TRU:	101072715(fat4) 101077501 101080210 105417098

TFS:	130531432(fat4)

TNG:	GSTEN00010794G001 GSTEN00010876G001 GSTEN00011903G001 GSTEN00011904G001 GSTEN00024499G001 GSTEN00024503G001

LCO:	104927630(fat4) 109138414 109139183

NCC:	104953884 104967208 104967626

TBEN:

117485263

CGOB:

115014520(fat4)

PGEO:

117453395 117454003

GACU:

117540257 117540449

EMAC:

134860057(fat4)

ELY:	117259597 117260612

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116671135 116676336 116697258(fat4)

PFLV:

114562357(fat4) 114562389

GAT:	120817011 120826415

PPUG:

119210599

AFB:	129089778 129090480 129090483

CLUM:

117737241

PSWI:

130209465(fat4)

MSAM:

119882482 119888689

SCHU:

122879166 122880138

CUD:

121516541

ALAT:

119007587 119008035 119008931

MZE:	101465158(fat4) 101465395

ONL:	100712359(fat4) 102080140

OAU:

116311470

OLA:	101165038(fat4) 111948066

OML:	112138525 112149360

CSAI:

133442566 133447729 133447762(fat4)

XMA:	102227967(fat4)

XCO:	114138984(fat4)

XHE:	116714190(fat4)

PRET:

103471885(fat4) 103475191

PFOR:

103140720 103152174(fat4)

PLAI:

106939803 106955248(fat4)

PMEI:

106921046 106927235(fat4) 106930592

GAF:

122837066

PPRL:

129358867 129360770 129360800

CVG:	107092107 107096337(fat4)

CTUL:

119798822

GMU:	124860326 124860717

NFU:	107380352(fat4) 107380558

KMR:	108235947 108249952

ALIM:

106514163 106521519 106528349(fat4)

NWH:

119408633

AOCE:

111566364 111576748 111584523(fat4)

MCEP:

125007781 125013032

CSEM:

103390662(fat4) 103390856

POV:

109640004

SSEN:

122773527 122778181

HHIP:

117769114 117772740

HSP:	118106130 118112127

PPLT:

128445644

SMAU:

118319371

LCF:	108876018 108901513

SDU:	111232543 111232595(fat4)

SLAL:

111644647(fat4) 111653089

XGL:	120785677 120785678

HCQ:	109518697 109528947 109529055(fat4)

SSCV:

125986514

SBIA:

133508459(fat4) 133509016

PEE:	133407489(fat4)

PTAO:

133484492(fat4)

BPEC:

110153689(fat4) 110160718

MALB:

109951818 109951821 109955471 109955508 109956714(fat4) 109967494

BSPL:

114864202(fat4) 114868072

SJO:	128362608 128363439

SASA:

106604622 106611628 106612434

STRU:

115171327 115205155(fat4) 115205851

OTW:	112216704 112221014 112256294

OMY:	110488886 110490083 110505081

OGO:	123993469 123993809 124010395

ONE:	115106794 115129515 115130030 115130762(fat4)

OKI:	109864675 109905240 109910162

OKE:	118363553 118366032 118378919

SALP:

111965793 111967547(fat4) 112068224

SNH:	120046971 120061886

CCLU:

121534178 121541796 121567295

ELS:	105028103(fat4) 105030468

SFM:	108938712(fat4)

PKI:	111835488(fat4) 111851363 111855394

AANG:

118209153 118231953

LOC:	102690718 102691473(fat4)

PSPA:

121302554 121323621 121328870

ARUT:

117406173 117409425 117421253

PSEX:

120523965 120527614

LCM:	102345629 102349174(FAT4)

CMK:	103182160 103183281 103184154 103184156 103184157 103184166

RTP:	109910651 109929705

CPLA:

122539345 122556970 122556974

HOC:	132823105 132823108 132823111 132823117 132833282(fat4)

LERI:

129701362 129701366 129701367 129701368 129701369 129704395(fat4)

PMRN:

116942765(FAT4) 116955726

LRJ:	133342996 133357736

BFO:	118415558 118416151 118416153 118419233

BBEL:

109466722 109469253 109480513 109486451 109486454 109487846

CIN:

100179785

SCLV:

120345474

SPU:	115922231 580453

LPIC:

129260658

APLC:

110979822 110983249

ARUN:

117305588

SKO:	100329017 100367103 100369355 100371900 100372350 100372841 100373359 100375711 100377212 102807550 102809566

DME:	Dmel_CG3352(ft)

DER:

6541979

DSE:

6613320

DSI:	Dsimw501_GD22718(Dsim_GD22718)

DYA:	Dyak_GE14764

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16125

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110675253 5568083

AALB:

109411674 115262175

ASUA:

134204214 134210508

CQU:	CpipJ_CPIJ002422

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105679387(ft)

PGC:	109859014 109859650

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	659713(FAT)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208459 KGM_208460

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119834705 119834734

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106677106(ft)

NLU:

111064644

HVI:

124356560

MQU:	128983945 128987233

PHU:	Phum_PHUM348500

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_329129

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:	119436986 119449586

RSAN:

119382530 119397454

RMP:	119161333 119163282

VDE:	111243433 111255326

VJA:	111262520 111266981

TUT:	107366361 107368187

DPTE:

113790021 113797098

DFR:	124494064 124496627

CSCU:

111612416 111620538 111627930 111630627

CVS:	136980358 136982254(ft) 136985097

PTEP:

107436315 107443710

ABRU:

129958215 129971459

UDV:	129220625 129231044

SDM:	118181495 118184145

LPOL:

106461886 106465589 106470467 106471517

PMEO:

129580754

NAI:	NECAME_07565

LOA:	LOAG_03168 LOAG_03530

TSP:

Tsp_12274

LGI:	LOTGIDRAFT_105163 LOTGIDRAFT_229554

PVUL:

126831181

PCAN:

112559617 112566268 112572342 112576226

BGT:	106057322 106069582 106074806 106074824 106079389

GAE:	121368788 121370037 121376522 121378667 121378881 121379466

HRF:	124110627 124112238 124112239 124115459 124133517 124136618 124136628 124136636 124139630 124141185 124144573 124144897 124147332 124150742 124152265 125371610

HRJ:	124255331 124258547 124259851 124262111 124264951 124270629 124272929 124273602 124273623 124279598 124286671 124286672 124286674 124288892

CRG:	105322148 105330502 105330795 105334403 105341032 105344514 105346939 105347723

CANU:

128156267

CVN:	111118235 111122406 111122407 111125357

OED:	125667248 125670462

MYI:	110449684 110451854 110453939 110462255 110463554

PMAX:

117328852 117331162 117333914 117337743

MMER:

123524194 123530447 123560115 123562369 128557148

RPHI:

132730948 132755309

DPOL:

127876532

MAEA:

128217885 128217886 128226950

OBI:	106874390 106875431 106882952

OSN:	115211772 115218254 115218781 115218938 115219113 115219374 115219393 115221607 115223206 118766121

LJP:	135467065 135468106 135468107 135472525 135472768 135473333 135473347 135482397

LAK:	106155966 106157571 106159275 106165535 106167362 106172188 106173124 106174464 106177594

LLON:

135487504 135487830 135493193

NVE:	116612238 5506165 5506831 5511118 5511600 5512766 5512789 5518243

EPA:	110232040 110242326 110247867 110250075 110251916

ATEN:

116287419 116294657 116297198 116298385 116301316 116303075

ADF:	107340005 107345827 107351191 107351194

AMIL:

114953789 114960913 114963645 114964584 114976095

PDAM:

113665764 113667006 113680072 113682966 113683425 113685866 113686719

SPIS:

111323512 111324842 111328931 111334412 111335349 111338214

DGT:	114521424 114521773 114521936 114522728 114522731 114523142 114523269

XEN:	124433315 124433318 124434139 124445598 124453689

HMG:	100204612 100210072

HSY:	130625146 130626170 130655582

RES:

135685964

TAD:	TRIADDRAFT_10055

AQU:	100636493 100637245 100639195 105312062 105314805 105316484 105316885 105316886 109581300

MBR:	MONBRDRAFT_11672(MBCDH16) MONBRDRAFT_12200(MBCDH18) MONBRDRAFT_29591(MBCDH19) MONBRDRAFT_31013(MBCDH9) MONBRDRAFT_37884(MBCDH5)

SRE:	PTSG_06458 PTSG_08442

PIF:	PITG_09983

PSOJ:

PHYSODRAFT_490482

VKA:	BTD91_14280

GAI:	IMCC3135_13125

CBX:	Cenrod_0683

FAQ:	G5B39_01855

DAL:

Dalk_0547

CCUR:

IAR63_08455

PIR:	VN12_08270

MFF:	MFFC18_22730

FSU:	Fisuc_2378

FSC:

FSU_2932

» show all

Reference

PMID:15003449

Authors

Hong JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y

Title

Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.

Journal

J Mol Biol 337:307-17 (2004)
DOI:10.1016/j.jmb.2004.01.026

Sequence

[hsa:79633]

Reference

PMID:18604206

Authors

Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, McNeill H

Title

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

Journal

Nat Genet 40:1010-5 (2008)
DOI:10.1038/ng.179

Sequence

[mmu:329628]

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