KEGG   ORTHOLOGY: K16689
Entry
K16689                      KO                                     
Symbol
UPD
Name
unpaired
Pathway
map04391  Hippo signaling pathway - fly
map04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04391 Hippo signaling pathway - fly
    K16689  UPD; unpaired
   04630 JAK-STAT signaling pathway
    K16689  UPD; unpaired
Genes
DME: Dmel_CG33542(upd3) Dmel_CG5988(upd2) Dmel_CG5993(upd1)
DER: 6550112 6550276 6550280
DSE: 6614839 6614846
DSI: Dsimw501_GD15648(Dsim_GD15648) Dsimw501_GD15650(Dsim_GD15650) Dsimw501_GD26961(Dsim_GD26961)
DYA: Dyak_GE15539 Dyak_GE15548 Dyak_GE17718
DSR: 110175975 110176074 110176081
DPO: 4814412 4814413 6901017
DPE: 6601759 6601760 6601785
DMN: 108151612 108164749 108165097
DWI: 6641111 6641122 6641257
ECOE: 129946331
CNS: 116344086
 » show all
Reference
PMID:9784499
  Authors
Harrison DA, McCoon PE, Binari R, Gilman M, Perrimon N
  Title
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.
  Journal
Genes Dev 12:3252-63 (1998)
DOI:10.1101/gad.12.20.3252
  Sequence
Reference
  Authors
Wright VM, Vogt KL, Smythe E, Zeidler MP
  Title
Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3.
  Journal
Cell Signal 23:920-7 (2011)
DOI:10.1016/j.cellsig.2011.01.020
  Sequence
Reference
  Authors
Osman D, Buchon N, Chakrabarti S, Huang YT, Su WC, Poidevin M, Tsai YC, Lemaitre B
  Title
Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division.
  Journal
J Cell Sci 125:5944-9 (2012)
DOI:10.1242/jcs.113100
  Sequence

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