KEGG   ORTHOLOGY: K16792
Entry
K16792                      KO                                     

Name
aksD
Definition
methanogen homoaconitase large subunit [EC:4.2.1.114]
Pathway
ko00300  Lysine biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
ko01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16792  aksD; methanogen homoaconitase large subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16792  aksD; methanogen homoaconitase large subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16792  aksD; methanogen homoaconitase large subunit
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0065
Genes
OBJ: EIO64_04565
RRS: RoseRS_1053
RCA: Rcas_3474
CAU: Caur_0329
CHL: Chy400_0354
CAG: Cagg_3602
HAU: Haur_3302
DRA: DR_1610
DGE: Dgeo_1156
DDR: Deide_13470
DMR: Deima_1355
DGO: DGo_CA1306
DPD: Deipe_2764
DSW: QR90_09055
DCH: SY84_02060
DPU: SU48_08715
DEZ: DKM44_08505
DWU: DVJ83_05635
DFC: DFI_07080
DEIN: DAAJ005_11930
DGA: DEGR_14160(leuC1)
TRA: Trad_1389
TTH: TT_C1547
TTJ: TTHA1911
TTS: Ththe16_1911
TTL: TtJL18_1993
TSC: TSC_c01880(hacA)
THC: TCCBUS3UF1_21070
TOS: Theos_1937
TAQ: TO73_0094
TPAR: AV541_01240
TBC: A0O31_00874
MRB: Mrub_2728
MRE: K649_08895
MSV: Mesil_0442
MTAI: Mtai_v1c23270
OPR: Ocepr_1780
MHD: Marky_0672
MJA: MJ_1003
MFE: Mefer_1231
MVU: Metvu_1303
MFS: MFS40622_1618
MIF: Metin_0516
MJH: JH146_0954
MIG: Metig_0807
MMP: MMP1480
MMQ: MmarC5_0098
MMX: MmarC6_1194
MMZ: MmarC7_0724
MMD: GYY_08235
MMAK: MMKA1_17030(leuD)
MMAO: MMOS7_15860(leuD)
MMAD: MMJJ_13590(dmdA_1)
MAE: Maeo_0311
MVN: Mevan_0789
MVO: Mvol_1623
MOK: Metok_0062
METF: CFE53_05095
MTH: MTH_1631
MMG: MTBMA_c02160(leuC1)
METC: MTCT_1490
MWO: MWSIV6_0177(hacA)
METE: tca_01581(dmdA_2)
METZ: METMT2_1470
METK: FVF72_03470
MTHM: FZP57_00775
MST: Msp_1100(leuC2)
METB: AW729_10315
MRU: mru_0384(aksD)
MSI: Msm_0723
MEB: Abm4_0180(aksD)
MMIL: sm9_2161(aksD)
MEYE: TL18_01065
MOL: YLM1_0055
MEL: Metbo_2070
MEW: MSWAN_0570
METH: MBMB1_0289(leuC2)
MFC: BRM9_1986(aksD)
MFI: DSM1535_0178(leuC2)
MCUB: MCBB_0567(hacA)
MSUB: BK009_11610
METN: BK008_07185
METT: CIT01_06840
METO: CIT02_05440
MFV: Mfer_0965
MKA: MK1208(leuC_2)
MBA: Mbar_A1961
MBY: MSBRM_0704
MBW: MSBRW_2776
MBAR: MSBR2_1672
MBAK: MSBR3_1673
MAC: MA_3085(leuC)
MMA: MM_0409
MMAZ: MmTuc01_0417
MMJ: MSMAS_0894
MMAC: MSMAC_0883
MVC: MSVAZ_1170
MEK: MSKOL_1122
MLS: MSLAZ_2100
METM: MSMTP_2281
MEF: MSWH1_0957
MEQ: MSWHS_1027
MSJ: MSSAC_2956
MSZ: MSSIH_2594
MSW: MSSIT_2634
MTHR: MSTHT_2523
MTHE: MSTHC_0762
MHOR: MSHOH_1131
MFZ: AOB57_002735
MBU: Mbur_2263(hacA)
MMET: MCMEM_0412
MMH: Mmah_0418
MHAZ: BHR79_01390
MEV: Metev_1371
MZH: Mzhil_0725
MPY: Mpsy_2821
MZI: HWN40_08640
MHZ: Metho_0694
MTP: Mthe_0788
MCJ: MCON_0444(leuC1)
MHI: Mhar_1525
MHU: Mhun_1800
MLA: Mlab_0233
MEM: Memar_0634
MBG: BN140_1717(leuC3)
MEMA: MMAB1_2209(leuC)
MPI: Mpet_2489
MBN: Mboo_0599
MFO: Metfor_2592
MPL: Mpal_2143
MPD: MCP_1961
MEZ: Mtc_1559(leuC-2)
RCI: RCIX2646(leuC-2)
 » show all
Reference
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1003]

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (18)   
   KEGG PATHWAY (16)   
   KEGG MODULE (2)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (3)   
Gene (164)   
   KEGG GENES (133)   
   KEGG MGENES (16)   
   RefGene (10)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (200)   

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KEGG   ORTHOLOGY: K16793
Entry
K16793                      KO                                     

Name
aksE
Definition
methanogen homoaconitase small subunit [EC:4.2.1.114]
Pathway
ko00300  Lysine biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
ko01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16793  aksE; methanogen homoaconitase small subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16793  aksE; methanogen homoaconitase small subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16793  aksE; methanogen homoaconitase small subunit
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0066
Genes
BOH: AKI39_19115
RRS: RoseRS_1056
RCA: Rcas_3472
CAU: Caur_0330
CHL: Chy400_0355
CAG: Cagg_3601
HAU: Haur_3303
DRA: DR_1614(leuD)
DGE: Dgeo_1154
DDR: Deide_13460
DMR: Deima_1353
DGO: DGo_CA1308
DPD: Deipe_2762
DSW: QR90_07810
DCH: SY84_02050
DAB: AUC44_07725
DPU: SU48_08705
DEZ: DKM44_08520
DWU: DVJ83_05640
DFC: DFI_07070
DEIN: DAAJ005_09955
DGA: DEGR_14180(leuD1)
TRA: Trad_1390
TTH: TT_C1546
TTJ: TTHA1910
TTS: Ththe16_1910
TTL: TtJL18_1992
TSC: TSC_c01890(hacB)
THC: TCCBUS3UF1_21060
TOS: Theos_1936
TAQ: TO73_0095
TPAR: AV541_01245
TBC: A0O31_00873
MRB: Mrub_2727
MRE: K649_08900
MSV: Mesil_0441
MTAI: Mtai_v1c23260
OPR: Ocepr_1781
MHD: Marky_0671
MJA: MJ_1271
MFE: Mefer_0048
MVU: Metvu_0677 Metvu_0864
MFS: MFS40622_0030 MFS40622_0660
MIF: Metin_1437
MJH: JH146_0454
MIG: Metig_0050 Metig_1570
MMP: MMP0381
MMQ: MmarC5_1257
MMX: MmarC6_0529
MMZ: MmarC7_1379
MMAK: MMKA1_04000(leuD)
MMAO: MMOS7_03940(leuD)
MMAD: MMJJ_06580(dmdB_1)
MAE: Maeo_0652
MVN: Mevan_1368
MVO: Mvol_1671
MOK: Metok_0567
METF: CFE53_04745
MTH: MTH_829
MMG: MTBMA_c12270(leuD1)
METC: MTCT_0743
MWO: MWSIV6_1206(hacB)
METE: tca_00796(DmdB_1)
METZ: METMT2_0903
METK: FVF72_07395
MTHM: FZP57_05725
MST: Msp_0374(leuD2)
METB: AW729_05200
MRU: mru_1689(aksE)
MSI: Msm_0847
MEB: Abm4_0514(aksE)
MMIL: sm9_1773(aksE)
MEYE: TL18_07930
MOL: YLM1_1157
MEL: Metbo_1944
MEW: MSWAN_0676
METH: MBMB1_0696(leuD1)
MFC: BRM9_1499(aksE)
MFI: DSM1535_2193(leuD1)
MCUB: MCBB_0707(hacB)
MSUB: BK009_01700
METN: BK008_09225
METT: CIT01_01955
METO: CIT02_03290
MFV: Mfer_0205
MKA: MK1206(leuD_2)
MBA: Mbar_A0244 Mbar_A2270
MBY: MSBRM_1355 MSBRM_2710
MBW: MSBRW_0751 MSBRW_2476
MBAR: MSBR2_1054 MSBR2_2666
MBAK: MSBR3_1018 MSBR3_2760
MAC: MA_1223(leuC) MA_3751(leuD)
MMA: MM_0645
MMAZ: MmTuc01_0660
MMJ: MSMAS_0664
MMAC: MSMAC_0666
MVC: MSVAZ_0690 MSVAZ_2221
MEK: MSKOL_0668 MSKOL_2220
MLS: MSLAZ_2434
METM: MSMTP_0731
MEF: MSWH1_0826
MEQ: MSWHS_0885
MSJ: MSSAC_3368 MSSAC_3559
MSZ: MSSIH_2894 MSSIH_3101
MSW: MSSIT_2938 MSSIT_3158
MTHR: MSTHT_2374
MTHE: MSTHC_0906
MHOR: MSHOH_0786
MFZ: AOB57_003550
MBU: Mbur_1578
MMET: MCMEM_2089
MMH: Mmah_0127
MHAZ: BHR79_02815
MEV: Metev_1312
MZH: Mzhil_1660
MPY: Mpsy_2354
MZI: HWN40_10575
MHZ: Metho_0481
MTP: Mthe_0853
MCJ: MCON_1922(leuD1)
MHI: Mhar_2395
MHU: Mhun_1799
MLA: Mlab_0234
MEM: Memar_0635
MBG: BN140_1716(leuD3)
MPI: Mpet_2490
MBN: Mboo_0600
MFO: Metfor_2591
MPL: Mpal_2144
MPD: MCP_1962
MEZ: Mtc_1558(leuD-2)
RCI: RCIX2645(leuD-2)
CDIV: CPM_1676
 » show all
Reference
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1271]

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (18)   
   KEGG PATHWAY (16)   
   KEGG MODULE (2)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (3)   
Gene (163)   
   KEGG GENES (147)   
   KEGG MGENES (3)   
   RefGene (5)   
   OC (8)   
Literature (1)   
   PubMed (1)   
All databases (199)   

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KEGG   ENZYME: 4.2.1.114
Entry
EC 4.2.1.114                Enzyme                                 

Name
methanogen homoaconitase;
methanogen HACN
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
Reaction(IUBMB)
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction) [RN:R09720];
(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O [RN:R03444];
(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [RN:R04371]
Reaction(KEGG)
Substrate
(R)-2-hydroxybutane-1,2,4-tricarboxylate [CPD:C01251];
(Z)-but-1-ene-1,2,4-tricarboxylate [CPD:C04002];
H2O [CPD:C00001]
Product
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
(Z)-but-1-ene-1,2,4-tricarboxylate [CPD:C04002];
H2O [CPD:C00001]
Comment
This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomocitrate and trihomocitrate as well as the non-physiological substrate tetrahomocitrate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.
History
EC 4.2.1.114 created 2009
Pathway
ec00300  Lysine biosynthesis
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K16792  methanogen homoaconitase large subunit
K16793  methanogen homoaconitase small subunit
Genes
BOH: AKI39_19115
OBJ: EIO64_04565
RRS: RoseRS_1053 RoseRS_1056
RCA: Rcas_3472 Rcas_3474
CAU: Caur_0329 Caur_0330
CHL: Chy400_0354 Chy400_0355
CAG: Cagg_3601 Cagg_3602
HAU: Haur_3302 Haur_3303
DRA: DR_1610 DR_1614(leuD)
DGE: Dgeo_1154 Dgeo_1156
DDR: Deide_13460 Deide_13470
DMR: Deima_1353 Deima_1355
DGO: DGo_CA1306 DGo_CA1308
DPD: Deipe_2762 Deipe_2764
DSW: QR90_07810 QR90_09055
DCH: SY84_02050 SY84_02060
DAB: AUC44_07725
DPU: SU48_08705 SU48_08715
DEZ: DKM44_08505 DKM44_08520
DWU: DVJ83_05635 DVJ83_05640
DFC: DFI_07070 DFI_07080
DEIN: DAAJ005_09955 DAAJ005_11930
DGA: DEGR_14160(leuC1) DEGR_14180(leuD1)
TRA: Trad_1389 Trad_1390
TTH: TT_C1546 TT_C1547
TTJ: TTHA1910 TTHA1911
TTS: Ththe16_1910 Ththe16_1911
TTL: TtJL18_1992 TtJL18_1993
TSC: TSC_c01880(hacA) TSC_c01890(hacB)
THC: TCCBUS3UF1_21060 TCCBUS3UF1_21070
TOS: Theos_1936 Theos_1937
TAQ: TO73_0094 TO73_0095
TPAR: AV541_01240 AV541_01245
TBC: A0O31_00873 A0O31_00874
MRB: Mrub_2727 Mrub_2728
MRE: K649_08895 K649_08900
MSV: Mesil_0441 Mesil_0442
MTAI: Mtai_v1c23260 Mtai_v1c23270
OPR: Ocepr_1780 Ocepr_1781
MHD: Marky_0671 Marky_0672
MJA: MJ_1003 MJ_1271
MFE: Mefer_0048 Mefer_1231
MVU: Metvu_0677 Metvu_0864 Metvu_1303
MFS: MFS40622_0030 MFS40622_0660 MFS40622_1618
MIF: Metin_0516 Metin_1437
MJH: JH146_0454 JH146_0954
MIG: Metig_0050 Metig_0807 Metig_1570
MMP: MMP0381 MMP1480
MMQ: MmarC5_0098 MmarC5_1257
MMX: MmarC6_0529 MmarC6_1194
MMZ: MmarC7_0724 MmarC7_1379
MMD: GYY_08235
MMAK: MMKA1_04000(leuD) MMKA1_17030(leuD)
MMAO: MMOS7_03940(leuD) MMOS7_15860(leuD)
MMAD: MMJJ_06580(dmdB_1) MMJJ_13590(dmdA_1)
MAE: Maeo_0311 Maeo_0652
MVN: Mevan_0789 Mevan_1368
MVO: Mvol_1623 Mvol_1671
MOK: Metok_0062 Metok_0567
METF: CFE53_04745 CFE53_05095
MTH: MTH_1631 MTH_829
MMG: MTBMA_c02160(leuC1) MTBMA_c12270(leuD1)
METC: MTCT_0743 MTCT_1490
MWO: MWSIV6_0177(hacA) MWSIV6_1206(hacB)
METE: tca_00796(DmdB_1) tca_01581(dmdA_2)
METZ: METMT2_0903 METMT2_1470
METK: FVF72_03470 FVF72_07395
MTHM: FZP57_00775 FZP57_05725
MST: Msp_0374(leuD2) Msp_1100(leuC2)
METB: AW729_05200 AW729_10315
MRU: mru_0384(aksD) mru_1689(aksE)
MSI: Msm_0723 Msm_0847
MEB: Abm4_0180(aksD) Abm4_0514(aksE)
MMIL: sm9_1773(aksE) sm9_2161(aksD)
MEYE: TL18_01065 TL18_07930
MOL: YLM1_0055 YLM1_1157
MEL: Metbo_1944 Metbo_2070
MEW: MSWAN_0570 MSWAN_0676
METH: MBMB1_0289(leuC2) MBMB1_0696(leuD1)
MFC: BRM9_1499(aksE) BRM9_1986(aksD)
MFI: DSM1535_0178(leuC2) DSM1535_2193(leuD1)
MCUB: MCBB_0567(hacA) MCBB_0707(hacB)
MSUB: BK009_01700 BK009_11610
METN: BK008_07185 BK008_09225
METT: CIT01_01955 CIT01_06840
METO: CIT02_03290 CIT02_05440
MFV: Mfer_0205 Mfer_0965
MKA: MK1206(leuD_2) MK1208(leuC_2)
MBA: Mbar_A0244 Mbar_A1961 Mbar_A2270
MBY: MSBRM_0704 MSBRM_1355 MSBRM_2710
MBW: MSBRW_0751 MSBRW_2476 MSBRW_2776
MBAR: MSBR2_1054 MSBR2_1672 MSBR2_2666
MBAK: MSBR3_1018 MSBR3_1673 MSBR3_2760
MAC: MA_1223(leuC) MA_3085(leuC) MA_3751(leuD)
MMA: MM_0409 MM_0645
MMAZ: MmTuc01_0417 MmTuc01_0660
MMJ: MSMAS_0664 MSMAS_0894
MMAC: MSMAC_0666 MSMAC_0883
MVC: MSVAZ_0690 MSVAZ_1170 MSVAZ_2221
MEK: MSKOL_0668 MSKOL_1122 MSKOL_2220
MLS: MSLAZ_2100 MSLAZ_2434
METM: MSMTP_0731 MSMTP_2281
MEF: MSWH1_0826 MSWH1_0957
MEQ: MSWHS_0885 MSWHS_1027
MSJ: MSSAC_2956 MSSAC_3368 MSSAC_3559
MSZ: MSSIH_2594 MSSIH_2894 MSSIH_3101
MSW: MSSIT_2634 MSSIT_2938 MSSIT_3158
MTHR: MSTHT_2374 MSTHT_2523
MTHE: MSTHC_0762 MSTHC_0906
MHOR: MSHOH_0786 MSHOH_1131
MFZ: AOB57_002735 AOB57_003550
MBU: Mbur_1578 Mbur_2263(hacA)
MMET: MCMEM_0412 MCMEM_2089
MMH: Mmah_0127 Mmah_0418
MHAZ: BHR79_01390 BHR79_02815
MEV: Metev_1312 Metev_1371
MZH: Mzhil_0725 Mzhil_1660
MPY: Mpsy_2354 Mpsy_2821
MZI: HWN40_08640 HWN40_10575
MHZ: Metho_0481 Metho_0694
MTP: Mthe_0788 Mthe_0853
MCJ: MCON_0444(leuC1) MCON_1922(leuD1)
MHI: Mhar_1525 Mhar_2395
MHU: Mhun_1799 Mhun_1800
MLA: Mlab_0233 Mlab_0234
MEM: Memar_0634 Memar_0635
MBG: BN140_1716(leuD3) BN140_1717(leuC3)
MEMA: MMAB1_2209(leuC)
MPI: Mpet_2489 Mpet_2490
MBN: Mboo_0599 Mboo_0600
MFO: Metfor_2591 Metfor_2592
MPL: Mpal_2143 Mpal_2144
MPD: MCP_1961 MCP_1962
MEZ: Mtc_1558(leuD-2) Mtc_1559(leuC-2)
RCI: RCIX2645(leuD-2) RCIX2646(leuC-2)
CDIV: CPM_1676
 » show all
Reference
1  [PMID:18765671]
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.114
IUBMB Enzyme Nomenclature: 4.2.1.114
ExPASy - ENZYME nomenclature database: 4.2.1.114
BRENDA, the Enzyme Database: 4.2.1.114

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Pathway (12)   
   KEGG PATHWAY (10)   
   KEGG MODULE (2)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (12)   
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   KEGG RCLASS (3)   
Gene (316)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (280)   
   KEGG MGENES (19)   
   RefGene (15)   
Protein sequence (240)   
   UniProt (229)   
   SWISS-PROT (9)   
   RefSeq(pep) (1)   
   PDBSTR (1)   
DNA sequence (19)   
   RefSeq(nuc) (2)   
   GenBank (9)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (11)   
   InterPro (11)   
All databases (621)   

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KEGG   REACTION: R10393
Entry
R10393                      Reaction                               

Name
(-)-threo-iso(homo)2-citrate hydro-lyase
Definition
cis-(Homo)2-aconitate + H2O <=> (-)-threo-Iso(homo)2-citrate
Equation
Comment
second step of two-step reaction (see R10391, R10392+R10393)
Reaction class
RC00618  C16597_C20581
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (282)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (280)   
All databases (297)   

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