KEGG   ORTHOLOGY: K16816
Entry
K16816                      KO                                     

Name
PNPLA2, ATGL
Definition
patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]
Pathway
ko00561  Glycerolipid metabolism
ko01100  Metabolic pathways
ko04714  Thermogenesis
ko04923  Regulation of lipolysis in adipocytes
Module
M00098  Acylglycerol degradation
Disease
H01297  Neutral lipid storage disease with myopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Other DBs
RN: R02250 R02687
GO: 0004806
Genes
HSA: 57104(PNPLA2)
PTR: 112207805 450937(PNPLA2)
PPS: 100970121(PNPLA2)
GGO: 101145251(PNPLA2)
PON: 100438169(PNPLA2)
NLE: 100607328(PNPLA2)
MCC: 700824(PNPLA2)
MCF: 102141858(PNPLA2)
CSAB: 103233992(PNPLA2)
RRO: 104681771(PNPLA2)
RBB: 108513010(PNPLA2)
CJC: 100408814(PNPLA2)
SBQ: 101033046(PNPLA2)
MMU: 66853(Pnpla2)
MCAL: 110298572(Pnpla2)
MPAH: 110322307(Pnpla2)
RNO: 100911615 361676(Pnpla2)
MUN: 110553920(Pnpla2)
CGE: 100753746(Pnpla2)
NGI: 103751092(Pnpla2)
HGL: 101701275(Pnpla2)
CCAN: 109698331(Pnpla2)
TUP: 102481526(PNPLA2)
CFA: 611403(PNPLA2)
VVP: 112924122(PNPLA2)
AML: 100463707(PNPLA2)
UMR: 103671100(PNPLA2)
UAH: 113248812(PNPLA2)
ORO: 101376822(PNPLA2)
ELK: 111150106
FCA: 101082263(PNPLA2)
PTG: 102955281(PNPLA2)
PPAD: 109259787(PNPLA2)
AJU: 106988897(PNPLA2)
BTA: 508493(PNPLA2)
BOM: 102280861(PNPLA2)
BBUB: 102409429(PNPLA2)
CHX: 100860889(PNPLA2)
OAS: 101123166(PNPLA2)
SSC: 100049704(PNPLA2)
CFR: 102522737(PNPLA2)
CDK: 105105445(PNPLA2)
BACU: 102997570(PNPLA2)
LVE: 103080064(PNPLA2)
OOR: 101283683(PNPLA2)
DLE: 111170300(PNPLA2)
PCAD: 102980462(PNPLA2)
ECB: 100146758(PNPLA2)
EPZ: 103544296(PNPLA2)
EAI: 106824961(PNPLA2)
MYB: 102242697(PNPLA2)
MYD: 102764823(PNPLA2)
MNA: 107542321(PNPLA2)
HAI: 109375650(PNPLA2)
DRO: 112317241(PNPLA2)
PALE: 102878066(PNPLA2)
RAY: 107507296(PNPLA2)
MJV: 108408640(PNPLA2)
LAV: 100657987(PNPLA2)
TMU: 101353614
MDO: 100031359(PNPLA2)
SHR: 100925043(PNPLA2)
PCW: 110202950(PNPLA2)
OAA: 103168938(PNPLA2)
GGA: 418233(PNPLA3) 431066(PNPLA2)
MGP: 100294555(PNPLA2)
CJO: 107314514(PNPLA2) 107317383
NMEL: 110396835 110401530(PNPLA2)
APLA: 101796497(PNPLA2) 101802708
ACYG: 106031781(PNPLA2) 106038244
TGU: 100219060(PNPLA2) 100231669
LSR: 110473186 110484489(PNPLA2)
SCAN: 103819680 103824075(PNPLA2)
GFR: 102044651 102044787(PNPLA2)
FAB: 101805858(PNPLA2) 101820592
PHI: 102100353(PNPLA2) 102102532
PMAJ: 107205005 107205543(PNPLA2)
CCAE: 111923366 111930735(PNPLA2)
CCW: 104688026(PNPLA2) 104696128
ETL: 114064564 114068481(PNPLA2)
FPG: 101917296 101922710(PNPLA2)
FCH: 102055351 102059870(PNPLA2)
CLV: 102085397 102093271(PNPLA2)
EGZ: 104127095(PNPLA2) 104135158
NNI: 104012676(PNPLA5) 104017312(PNPLA2)
ACUN: 113480980(PNPLA2) 113490465
PADL: 103916456(PNPLA2) 103924466
AAM: 106488311 106490004(PNPLA2)
ASN: 102381486(PNPLA2)
AMJ: 102569620(PNPLA2)
PSS: 102443833 102450379(PNPLA2)
CMY: 102931307(PNPLA2) 102938324
CPIC: 101936184 101948343(PNPLA2)
ACS: 100551847(pnpla2)
PVT: 110074181(PNPLA2)
PBI: 103048393(PNPLA2)
PMUR: 107283959(PNPLA2)
TSR: 106542070(PNPLA2)
PMUA: 114599534(PNPLA2)
GJA: 107116418(PNPLA2)
XLA: 108713865(pnpla2.L) 108715180(pnpla2.S)
XTR: 780152(pnpla2)
NPR: 108794583(PNPLA2)
DRE: 101887155(pnpla2)
IPU: 108269288 108274701(pnpla2)
PHYP: 113529505(pnpla2) 113546554
AMEX: 103023613 103029861(pnpla2)
EEE: 113588195
OTW: 112242251
SFM: 108939144 108941267(pnpla2)
PKI: 111848020(pnpla2)
LCM: 102349054(PNPLA2) 102364578(PNPLA1)
CMK: 103186006(pnpla2)
RTP: 109926498
SPU: 582648
APLC: 110975490
SKO: 100374988
AME: 551055
BIM: 100747930
BTER: 100651324
CCAL: 108629084
OBB: 114878435
SOC: 105207573
MPHA: 105831282
AEC: 105144242
ACEP: 105619246
PBAR: 105432178
VEM: 105565342
HST: 105181728
DQU: 106746566
CFO: 105250235
LHU: 105676997
PGC: 109852332
OBO: 105284717
PCF: 106786103
NVI: 100118986
CSOL: 105365411
TCA: 659311(bmm)
DPA: 109534185
ATD: 109598159
NVL: 108562167
API: 100162729
DNX: 107163238
AGS: 114131901
RMD: 113548305
ZNE: 110829229
FCD: 110857045
DPTE: 113795201
PTEP: 107455774
CRG: 105328357
MYI: 110445973
LAK: 106181783
SHX: MS3_00389
ADF: 107346163
AMIL: 114958515
PDAM: 113669342
SPIS: 111325998
DGT: 114527358
HMG: 100205181
AQU: 100642049
 » show all
Reference
  Authors
Smirnova E, Goldberg EB, Makarova KS, Lin L, Brown WJ, Jackson CL
  Title
ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells.
  Journal
EMBO Rep 7:106-13 (2006)
DOI:10.1038/sj.embor.7400559
Reference
  Authors
Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R
  Title
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
  Journal
Science 306:1383-6 (2004)
DOI:10.1126/science.1100747
  Sequence
[hsa:57104]

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