KEGG   ORTHOLOGY: K16876
Entry
K16876                      KO                                     

Name
hmfD
Definition
2-furoate---CoA ligase [EC:6.2.1.31]
Pathway
ko00365  Furfural degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00365 Furfural degradation
    K16876  hmfD; 2-furoate---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.31  2-furoate---CoA ligase
     K16876  hmfD; 2-furoate---CoA ligase
Other DBs
RN: R02986
GO: 0047541
Genes
PPSE: BN5_2301(hmfD)
PMAN: OU5_0886
PSTT: CH92_11545
PPUU: PputUW4_02622
PSIL: PMA3_09785
PALL: UYA_10525
CSA: Csal_2523
ADI: B5T_02848
RPI: Rpic_2055
RPF: Rpic12D_1747
REH: H16_A1700(h16_A1700)
BXE: Bxe_A2076
BXB: DR64_4231
BPH: Bphy_6670
BFN: OI25_3191
CABA: SBC2_58980(fcbA2)
AMIM: MIM_c34410
ODI: ODI_R0531
HPSE: HPF_15735(fcbA2)
BJA: blr3536
RPC: RPC_0851
MET: M446_1304
MNO: Mnod_3299
MOR: MOC_3636
MAQU: Maq22A_c13980(caiC)
DSH: Dshi_3722
ACR: Acry_0671
GKA: GKP17 GKP25
GGH: GHH_c13600(menE1)
ANM: GFC28_301
AAD: TC41_0787
PDX: Psed_5934
PSEA: WY02_08315
PSEE: FRP1_29380
PAUT: Pdca_67720
AG: ADE20402(hmfD)
 » show all
Reference
  Authors
Koopman F, Wierckx N, de Winde JH, Ruijssenaars HJ
  Title
Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14.
  Journal
Proc Natl Acad Sci U S A 107:4919-24 (2010)
DOI:10.1073/pnas.0913039107
  Sequence

KEGG   ENZYME: 6.2.1.31
Entry
EC 6.2.1.31                 Enzyme                                 

Name
2-furoate---CoA ligase;
2-furoyl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
2-furoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA [RN:R02986]
Reaction(KEGG)
R02986
Substrate
ATP [CPD:C00002];
2-furoate [CPD:C01546];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
2-furoyl-CoA [CPD:C00845]
History
EC 6.2.1.31 created 1992
Pathway
ec00365  Furfural degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16876  2-furoate---CoA ligase
Genes
PPSE: BN5_2301(hmfD)
PMAN: OU5_0886
PSTT: CH92_11545
PPUU: PputUW4_02622
PSIL: PMA3_09785
PALL: UYA_10525
CSA: Csal_2523
ADI: B5T_02848
RPI: Rpic_2055
RPF: Rpic12D_1747
REH: H16_A1700(h16_A1700)
BXE: Bxe_A2076
BXB: DR64_4231
BPH: Bphy_6670
BFN: OI25_3191
CABA: SBC2_58980(fcbA2)
AMIM: MIM_c34410
ODI: ODI_R0531
HPSE: HPF_15735(fcbA2)
BJA: blr3536
RPC: RPC_0851
MET: M446_1304
MNO: Mnod_3299
MOR: MOC_3636
MAQU: Maq22A_c13980(caiC)
DSH: Dshi_3722
ACR: Acry_0671
GKA: GKP17 GKP25
GGH: GHH_c13600(menE1)
ANM: GFC28_301
AAD: TC41_0787
PDX: Psed_5934
PSEA: WY02_08315
PSEE: FRP1_29380
PAUT: Pdca_67720
 » show all
Reference
1  [PMID:16347977]
  Authors
Koenig K, Andreesen JR.
  Title
Molybdenum Involvement in Aerobic Degradation of 2-Furoic Acid by Pseudomonas putida Fu1.
  Journal
Appl Environ Microbiol 55:1829-1834 (1989)
DOI:10.1128/AEM.55.7.1829-1834.1989
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.31
IUBMB Enzyme Nomenclature: 6.2.1.31
ExPASy - ENZYME nomenclature database: 6.2.1.31
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.31
BRENDA, the Enzyme Database: 6.2.1.31
CAS: 122320-08-5

KEGG   REACTION: R02986
Entry
R02986                      Reaction                               

Name
2-furoate:CoA ligase (AMP-forming)
Definition
ATP + 2-Furoate + CoA <=> AMP + Diphosphate + 2-Furoyl-CoA
Equation
Reaction class
RC00004  C00010_C00845
RC00174  C00845_C01546
Enzyme
Pathway
rn00365  Furfural degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K16876  2-furoate---CoA ligase [EC:6.2.1.31]
Other DBs
RHEA: 19272

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