KEGG   ORTHOLOGY: K16967Help
Entry
K16967                      KO                                     

Name
dmoA
Definition
dimethyl-sulfide monooxygenase [EC:1.14.13.131]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K16967  dmoA; dimethyl-sulfide monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.131  dissimilatory dimethyl sulfide monooxygenase
     K16967  dmoA; dimethyl-sulfide monooxygenase
BRITE hierarchy
Other DBs
RN: R09786
GO: 0018633
Genes
AG: ADU77278(dmoA)
TaxonomyKoalaUniProt
Reference
  Authors
Boden R, Borodina E, Wood AP, Kelly DP, Murrell JC, Schafer H
  Title
Purification and characterization of dimethylsulfide monooxygenase from Hyphomicrobium sulfonivorans.
  Journal
J Bacteriol 193:1250-8 (2011)
DOI:10.1128/JB.00977-10
  Sequence

KEGG   ENZYME: 1.14.13.131Help
Entry
EC 1.14.13.131              Enzyme                                 

Name
dissimilatory dimethyl sulfide monooxygenase;
dmoAB (gene names);
dimethyl sulfide C-monooxygenase;
dimethylsulfide monooxygenase (ambiguous);
dimethyl sulfide monooxygenase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dimethyl sulfide,NADH:oxygen oxidoreductase
Reaction(IUBMB)
dimethyl sulfide + O2 + NADH + H+ = methanethiol + formaldehyde + NAD+ + H2O [RN:R09786]
Reaction(KEGG)
Substrate
dimethyl sulfide [CPD:C00580];
O2 [CPD:C00007];
NADH [CPD:C00004];
H+ [CPD:C00080]
Product
methanethiol [CPD:C00409];
formaldehyde [CPD:C00067];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme participates exclusively in sulfur dissimilation. It has lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides. Its activity is stimulated by combined addition of FMN, and, after depletion of cations, of Mg2+ and Fe2+. The enzymes from bacteria of the Hyphomicrobium genus are a two component system that includes an FMN-dependent reductase subunit and a monooxygenase subunit.
History
EC 1.14.13.131 created 2011
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K16967  dimethyl-sulfide monooxygenase
Reference
1
  Authors
De Bont, J.A.M., Van Dijken, J.P. and Harder, W.
  Title
Dimethyl sulphoxide and dimethyl sulphide as a carbon, sulphur and energy source for growth of Hyphomicrobium S.
  Journal
J Gen Microbiol 127:315-323 (1981)
Reference
2  [PMID:21216999]
  Authors
Boden R, Borodina E, Wood AP, Kelly DP, Murrell JC, Schafer H
  Title
Purification and characterization of dimethylsulfide monooxygenase from Hyphomicrobium sulfonivorans.
  Journal
J Bacteriol 193:1250-8 (2011)
DOI:10.1128/JB.00977-10
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.131
IUBMB Enzyme Nomenclature: 1.14.13.131
ExPASy - ENZYME nomenclature database: 1.14.13.131
BRENDA, the Enzyme Database: 1.14.13.131

KEGG   REACTION: R09786Help
Entry
R09786                      Reaction                               

Name
dimethyl sulfide,NADH:oxygen oxidoreductase
Definition
Dimethyl sulfide + Oxygen + NADH + H+ <=> Methanethiol + Formaldehyde + NAD+ + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC02653  C00409_C00580
RC02654  C00067_C00580
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K16967  dimethyl-sulfide monooxygenase [EC:1.14.13.131]
Other DBs
RHEA: 31358

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