KEGG   ORTHOLOGY: K17066
Entry
K17066                      KO                                     

Name
MOX
Definition
alcohol oxidase [EC:1.1.3.13]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K17066  MOX; alcohol oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.13  alcohol oxidase
     K17066  MOX; alcohol oxidase
Other DBs
RN: R00608
GO: 0047639
Genes
PPA: PAS_chr4_0152 PAS_chr4_0821
NCR: NCU01853
NTE: NEUTE1DRAFT54808(NEUTE1DRAFT_54808)
SMP: SMAC_06860
PAN: PODANSg3545 PODANSg873
TTT: THITE_2049403 THITE_2059741
MTM: MYCTH_98458
MGR: MGG_02127 MGG_09072
TMN: UCRPA7_6115 UCRPA7_6633
FGR: FGSG_03638 FGSG_07530
MAW: MAC_01220
MAJ: MAA_09229
CMT: CCM_09512
ANI: AN0567.2
ANG: ANI_1_1266134(An15g02200) ANI_1_712164(An18g05480)
PBL: PAAG_01979 PAAG_12459(PAAG_07884)
ABP: AGABI1DRAFT114404(AGABI1DRAFT_114404) AGABI1DRAFT114408(AGABI1DRAFT_114408) AGABI1DRAFT116682(AGABI1DRAFT_116682) AGABI1DRAFT85725(AGABI1DRAFT_85725) AGABI1DRAFT85732(AGABI1DRAFT_85732)
ABV: AGABI2DRAFT191438(AGABI2DRAFT_191438) AGABI2DRAFT191444(AGABI2DRAFT_191444) AGABI2DRAFT191450(AGABI2DRAFT_191450) AGABI2DRAFT195553(AGABI2DRAFT_195553)
 » show all
Reference
PMID:1882546
  Authors
van der Klei IJ, Harder W, Veenhuis M
  Title
Biosynthesis and assembly of alcohol oxidase, a peroxisomal matrix protein in methylotrophic yeasts: a review.
  Journal
Yeast 7:195-209 (1991)
DOI:10.1002/yea.320070302
Reference
PMID:2582370
  Authors
Ledeboer AM, Edens L, Maat J, Visser C, Bos JW, Verrips CT, Janowicz Z, Eckart M, Roggenkamp R, Hollenberg CP
  Title
Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha.
  Journal
Nucleic Acids Res 13:3063-82 (1985)
DOI:10.1093/nar/13.9.3063

KEGG   ENZYME: 1.1.3.13
Entry
EC 1.1.3.13                 Enzyme                                 

Name
alcohol oxidase;
ethanol oxidase;
alcohol:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
alcohol:oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
a primary alcohol + O2 = an aldehyde + H2O2 [RN:R00637]
Reaction(KEGG)
R00637 > R00608
Substrate
primary alcohol [CPD:C00226];
O2 [CPD:C00007]
Product
aldehyde [CPD:C00071];
H2O2 [CPD:C00027]
Comment
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
History
EC 1.1.3.13 created 1972
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17066  alcohol oxidase
Genes
PPA: PAS_chr4_0152 PAS_chr4_0821
NCR: NCU01853
NTE: NEUTE1DRAFT54808(NEUTE1DRAFT_54808)
SMP: SMAC_06860
PAN: PODANSg3545 PODANSg873
TTT: THITE_2049403 THITE_2059741
MTM: MYCTH_98458
MGR: MGG_02127 MGG_09072
TMN: UCRPA7_6115 UCRPA7_6633
FGR: FGSG_03638 FGSG_07530
MAW: MAC_01220
MAJ: MAA_09229
CMT: CCM_09512
ANI: AN0567.2
ANG: ANI_1_1266134(An15g02200) ANI_1_712164(An18g05480)
PBL: PAAG_01979 PAAG_12459(PAAG_07884)
ABP: AGABI1DRAFT114404(AGABI1DRAFT_114404) AGABI1DRAFT114408(AGABI1DRAFT_114408) AGABI1DRAFT116682(AGABI1DRAFT_116682) AGABI1DRAFT85725(AGABI1DRAFT_85725) AGABI1DRAFT85732(AGABI1DRAFT_85732)
ABV: AGABI2DRAFT191438(AGABI2DRAFT_191438) AGABI2DRAFT191444(AGABI2DRAFT_191444) AGABI2DRAFT191450(AGABI2DRAFT_191450) AGABI2DRAFT195553(AGABI2DRAFT_195553)
 » show all
Reference
1  [PMID:5636370]
  Authors
Janssen FW, Ruelius HW.
  Title
Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.
  Journal
Biochim Biophys Acta 151:330-42 (1968)
DOI:10.1016/0005-2744(68)90100-9
Reference
2
  Authors
Nishida, A., Ishihara, T. and Hiroi, T.
  Title
Studies on enzymes related to lignan biodegradation.
  Journal
Baiomasu Henkan Keikaku Kenkyu Hokoku 38-59 (1987)
Reference
3  [PMID:9142745]
  Authors
Suye S.
  Title
Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.
  Journal
Curr Microbiol 34:374-7 (1997)
DOI:10.1007/s002849900198
Reference
4  [PMID:26680532]
  Authors
Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H
  Title
Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
  Journal
Nat Commun 6:10197 (2015)
DOI:10.1038/ncomms10197
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.13
IUBMB Enzyme Nomenclature: 1.1.3.13
ExPASy - ENZYME nomenclature database: 1.1.3.13
BRENDA, the Enzyme Database: 1.1.3.13
CAS: 9073-63-6

KEGG   REACTION: R00608
Entry
R00608                      Reaction                               

Name
Methanol:oxygen oxidereductase
Definition
Methanol + Oxygen <=> Formaldehyde + Hydrogen peroxide
Equation
Reaction class
RC00034  C00067_C00132
RC02755  C00007_C00027
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K17066  alcohol oxidase [EC:1.1.3.13]

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