KEGG   ORTHOLOGY: K17067
Entry
K17067                      KO                                     

Name
mdo
Definition
formaldehyde dismutase / methanol dehydrogenase [EC:1.2.98.1 1.1.99.37]
Pathway
ko00625  Chloroalkane and chloroalkene degradation
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K17067  mdo; formaldehyde dismutase / methanol dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00625 Chloroalkane and chloroalkene degradation
    K17067  mdo; formaldehyde dismutase / methanol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.37  methanol dehydrogenase (nicotinoprotein)
     K17067  mdo; formaldehyde dismutase / methanol dehydrogenase
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.98  
    1.2.98.1  formaldehyde dismutase
     K17067  mdo; formaldehyde dismutase / methanol dehydrogenase
Other DBs
RN: R00614
COG: COG1454
GO: 0047895
Genes
GUR: Gura_3568
GEB: GM18_3226
GPI: GPICK_06680
DEX: HWD60_01710(mdo)
DVN: HQ394_08800(mdo)
DAE: Dtox_4270
MDX: BTO20_03135 BTO20_38200
MSM: MSMEG_6242
MSG: MSMEI_6081
MSB: LJ00_30865
MVA: Mvan_5479
MAUU: NCTC10437_05223(thcE)
ASD: AS9A_4308
NFA: NFA_22240
NFR: ERS450000_01873(thcE)
RER: RER_17770
REY: O5Y_08520
ROP: ROP_61160
RHB: NY08_1972
RRZ: CS378_08140(mdo)
RQI: C1M55_08995(mdo)
RRT: 4535765_03582(thcE)
RBY: CEJ39_19735(mdo)
GBR: Gbro_1931
GOR: KTR9_1872
GOC: CXX93_15365(mdo)
GIT: C6V83_07720(mdo)
GRU: GCWB2_09440(thcE)
GOM: D7316_01326(mno) D7316_03687(thcE)
GAV: C5O27_18320(mdo)
GOD: GKZ92_09040(mdo)
DIZ: CT688_01100(mdo)
TOY: FO059_05730(mdo)
SHY: SHJG_2446
PHW: G7075_01320(mdo)
NML: Namu_0777
SEN: SACE_2386
SACG: FDZ84_34730(mdo)
AMQ: AMETH_5577(mdo)
PSEA: WY02_13685
PSEH: XF36_28100
AG: ACS29499(mdo)
 » show all
Reference
  Authors
Park H, Lee H, Ro YT, Kim YM
  Title
Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).
  Journal
Microbiology 156:463-71 (2010)
DOI:10.1099/mic.0.034124-0
  Sequence

KEGG   ORTHOLOGY: K17068
Entry
K17068            Tight     KO                                     

Name
fdm
Definition
formaldehyde dismutase [EC:1.2.98.1]
Pathway
ko00625  Chloroalkane and chloroalkene degradation
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K17068  fdm; formaldehyde dismutase
  09111 Xenobiotics biodegradation and metabolism
   00625 Chloroalkane and chloroalkene degradation
    K17068  fdm; formaldehyde dismutase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.98  
    1.2.98.1  formaldehyde dismutase
     K17068  fdm; formaldehyde dismutase
Other DBs
RN: R00614
GO: 0047895
Genes
AG: AAA25818(fdm)
Reference
PMID:3514215
  Authors
Kato N, Yamagami T, Shimao M, Sakazawa C
  Title
Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.
  Journal
Eur J Biochem 156:59-64 (1986)
DOI:10.1111/j.1432-1033.1986.tb09548.x
  Sequence

KEGG   ENZYME: 1.2.98.1
Entry
EC 1.2.98.1                 Enzyme                                 

Name
formaldehyde dismutase;
aldehyde dismutase;
cannizzanase;
nicotinoprotein aldehyde dismutase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors
Sysname
formaldehyde:formaldehyde oxidoreductase
Reaction(IUBMB)
2 formaldehyde + H2O = formate + methanol [RN:R00614]
Reaction(KEGG)
R00614
Substrate
formaldehyde [CPD:C00067];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
methanol [CPD:C00132]
Comment
The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].
History
EC 1.2.98.1 created 1986 as EC 1.2.99.4, modified 2012, transferred 2015 to EC 1.2.98.1
Pathway
ec00625  Chloroalkane and chloroalkene degradation
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17067  formaldehyde dismutase / methanol dehydrogenase
K17068  formaldehyde dismutase
Genes
GUR: Gura_3568
GEB: GM18_3226
GPI: GPICK_06680
DEX: HWD60_01710(mdo)
DVN: HQ394_08800(mdo)
DAE: Dtox_4270
MDX: BTO20_03135 BTO20_38200
MSM: MSMEG_6242
MSG: MSMEI_6081
MSB: LJ00_30865
MVA: Mvan_5479
MAUU: NCTC10437_05223(thcE)
ASD: AS9A_4308
NFA: NFA_22240
NFR: ERS450000_01873(thcE)
RER: RER_17770
REY: O5Y_08520
ROP: ROP_61160
RHB: NY08_1972
RRZ: CS378_08140(mdo)
RQI: C1M55_08995(mdo)
RRT: 4535765_03582(thcE)
RBY: CEJ39_19735(mdo)
GBR: Gbro_1931
GOR: KTR9_1872
GOC: CXX93_15365(mdo)
GIT: C6V83_07720(mdo)
GRU: GCWB2_09440(thcE)
GOM: D7316_01326(mno) D7316_03687(thcE)
GAV: C5O27_18320(mdo)
GOD: GKZ92_09040(mdo)
DIZ: CT688_01100(mdo)
TOY: FO059_05730(mdo)
SHY: SHJG_2446
PHW: G7075_01320(mdo)
NML: Namu_0777
SEN: SACE_2386
SACG: FDZ84_34730(mdo)
AMQ: AMETH_5577(mdo)
PSEA: WY02_13685
PSEH: XF36_28100
 » show all
Reference
1
  Authors
Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C.
  Title
The dismutation of aldehydes by a bacterial enzyme.
  Journal
Agric Biol Chem 47:39-46 (1983)
Reference
2  [PMID:3514215]
  Authors
Kato N, Yamagami T, Shimao M, Sakazawa C
  Title
Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.
  Journal
Eur J Biochem 156:59-64 (1986)
DOI:10.1111/j.1432-1033.1986.tb09548.x
  Sequence
Reference
3  [PMID:19875438]
  Authors
Park H, Lee H, Ro YT, Kim YM
  Title
Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).
  Journal
Microbiology 156:463-71 (2010)
DOI:10.1099/mic.0.034124-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.98.1
IUBMB Enzyme Nomenclature: 1.2.98.1
ExPASy - ENZYME nomenclature database: 1.2.98.1
BRENDA, the Enzyme Database: 1.2.98.1
CAS: 85204-94-0

KEGG   REACTION: R00614
Entry
R00614                      Reaction                               

Name
formaldehyde:formaldehyde oxidoreductase
Definition
2 Formaldehyde + H2O <=> Formate + Methanol
Equation
Reaction class
RC00034  C00067_C00132
RC00188  C00058_C00067
Enzyme
Pathway
rn00625  Chloroalkane and chloroalkene degradation
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K17067  formaldehyde dismutase / methanol dehydrogenase [EC:1.2.98.1 1.1.99.37]
K17068  formaldehyde dismutase [EC:1.2.98.1]
Other DBs
RHEA: 19224

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