KEGG ORTHOLOGY: K17078

ORTHOLOGY: K17078

Entry

K17078                      KO

Symbol

neoL

Name

2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase [EC:3.5.1.112 3.5.1.113]

Pathway

map00524

Neomycin, kanamycin and gentamicin biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R08895

2'-N-acetylparomamine hydrolase (acetate-forming)

R08901

2'''-acetyl-6'''-hydroxyneomycin-C hydrolase (acetate-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.112  2'-N-acetylparomamine deacetylase
     K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
    3.5.1.113  2'''-acetyl-6'''-hydroxyneomycin C deacetylase
     K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase

Genes

PMUY:

KSS95_17150

SRN:	A4G23_05119(neoL)

SNF:	JYK04_00663(neoL)

SFB:	CP974_27320

STRY:

EQG64_18475

SDD:	D9753_07125 D9753_17065

SARG:

HKX69_16470

SPIQ:

OHA34_16955

DVC:	Dvina_05430

BSEN:

DP114_09560

BOX:	DP113_09520

AG:	BAD95829(neoL) CAE46942(kanN)

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Reference

PMID:18802637

Authors

Fan Q, Huang F, Leadlay PF, Spencer JB

Title

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.

Journal

Org Biomol Chem 6:3306-14 (2008)
DOI:10.1039/b808734b

Reference

PMID:16506694

Authors

Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K

Title

Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.

Journal

J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104

Sequence

[ag:BAD95829]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (15)   
   KEGG GENES (14)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (29)   

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ORTHOLOGY: K13551

Entry

K13551            Tight     KO

Symbol

btrD

Name

2'-N-acetylparomamine deacetylase [EC:3.5.1.112]

Pathway

map00524

Neomycin, kanamycin and gentamicin biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R08895

2'-N-acetylparomamine hydrolase (acetate-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K13551  btrD; 2'-N-acetylparomamine deacetylase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.112  2'-N-acetylparomamine deacetylase
     K13551  btrD; 2'-N-acetylparomamine deacetylase

Genes

AG:	BAE07068(btrD)

Reference

PMID:16156513

Authors

Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K

Title

Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.

Journal

J Antibiot (Tokyo) 58:373-9 (2005)
DOI:10.1038/ja.2005.47

Sequence

[ag:BAE07068]

Reference

PMID:19362652

Authors

Kudo F, Eguchi T

Title

Biosynthetic enzymes for the aminoglycosides butirosin and neomycin.

Journal

Methods Enzymol 459:493-519 (2009)
DOI:10.1016/S0076-6879(09)04620-5

Reference

PMID:17226887

Authors

Truman AW, Huang F, Llewellyn NM, Spencer JB

Title

Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin.

Journal

Angew Chem Int Ed Engl 46:1462-4 (2007)
DOI:10.1002/anie.200604194

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1)   
   KEGG GENES (1)   
Literature (3)   
   PubMed (3)   
All databases (14)   

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