KEGG   ORTHOLOGY: K17211
Entry
K17211            Tight     KO                                     

Name
CURS3
Definition
curcumin/demethoxycurcumin synthase [EC:2.3.1.217 2.3.1.219]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K17211  CURS3; curcumin/demethoxycurcumin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K17211  CURS3; curcumin/demethoxycurcumin synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.217  curcumin synthase
     K17211  CURS3; curcumin/demethoxycurcumin synthase
    2.3.1.219  demethoxycurcumin synthase
     K17211  CURS3; curcumin/demethoxycurcumin synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K17211  CURS3; curcumin/demethoxycurcumin synthase
Other DBs
RN: R08807 R08808 R08809 R08810
Genes
AG: BAH85781(CURS3)
Reference
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence

KEGG   ENZYME: 2.3.1.219
Entry
EC 2.3.1.219                Enzyme                                 

Name
demethoxycurcumin synthase;
CURS3
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming)
Reaction(IUBMB)
(1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2 [RN:R08809];
(2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 [RN:R08807]
Reaction(KEGG)
R08807 R08809
Substrate
4-coumaroyl-CoA [CPD:C00223];
feruloylacetyl-CoA [CPD:C17741];
H2O [CPD:C00001];
(4-coumaroyl)acetyl-CoA [CPD:C17740]
Product
CoA [CPD:C00010];
demethoxycurcumin [CPD:C17742];
CO2 [CPD:C00011];
bisdemethoxycurcumin [CPD:C17743]
Comment
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1].
History
EC 2.3.1.219 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17211  curcumin/demethoxycurcumin synthase
Reference
1  [PMID:19622354]
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb  Curcuma longa.
  Journal
FEBS Lett 583:2799-803 (2009)
DOI:10.1016/j.febslet.2009.07.029
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.219
IUBMB Enzyme Nomenclature: 2.3.1.219
ExPASy - ENZYME nomenclature database: 2.3.1.219
BRENDA, the Enzyme Database: 2.3.1.219

KEGG   REACTION: R08809
Entry
R08809                      Reaction                               

Name
p-coumaroyl-CoA:feruloyl-diketide-CoA C-coumaroyltransferase (thioester-hydrolysing and decarboxylating)
Definition
Feruloyl-diketide-CoA + p-Coumaroyl-CoA + H2O <=> Demethoxycurcumin + 2 CoA + CO2
Equation
Comment
curcuminoid synthase (CURS)
Reaction class
RC00004  C00010_C00223  C00010_C17741
RC02998  C17741_C17742
Enzyme
Pathway
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K17211  curcumin/demethoxycurcumin synthase [EC:2.3.1.217 2.3.1.219]
Other DBs
RHEA: 35122

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