KEGG   ORTHOLOGY: K17212
Entry
K17212                      KO                                     

Name
CUS
Definition
bisdemethoxycurcumin synthase [EC:2.3.1.211]
Pathway
ko00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
    K17212  CUS; bisdemethoxycurcumin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K17212  CUS; bisdemethoxycurcumin synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.211  bisdemethoxycurcumin synthase
     K17212  CUS; bisdemethoxycurcumin synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K17212  CUS; bisdemethoxycurcumin synthase
Other DBs
RN: R10233
Genes
OSA: 4342896
DOSA: Os07t0271500-01(Os07g0271500)
SBI: 8080716
ZMA: 100272924 109940988
SITA: 101760477
Reference
  Authors
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I
  Title
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
  Journal
Proc Natl Acad Sci U S A 107:19778-83 (2010)
DOI:10.1073/pnas.1011499107
  Sequence
[osa:4342896]

KEGG   ENZYME: 2.3.1.211
Entry
EC 2.3.1.211                Enzyme                                 

Name
bisdemethoxycurcumin synthase;
CUS;
curcuminoid synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
Reaction(IUBMB)
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN:R10233]
Reaction(KEGG)
R10233
Substrate
4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
bisdemethoxycurcumin [CPD:C17743];
CO2 [CPD:C00011]
Comment
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
History
EC 2.3.1.211 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17212  bisdemethoxycurcumin synthase
Genes
OSA: 4342896
DOSA: Os07t0271500-01(Os07g0271500)
SBI: 8080716
ZMA: 100272924 109940988
SITA: 101760477
Reference
1  [PMID:21041675]
  Authors
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I
  Title
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
  Journal
Proc Natl Acad Sci U S A 107:19778-83 (2010)
DOI:10.1073/pnas.1011499107
  Sequence
[osa:4342896]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.211
IUBMB Enzyme Nomenclature: 2.3.1.211
ExPASy - ENZYME nomenclature database: 2.3.1.211
BRENDA, the Enzyme Database: 2.3.1.211

KEGG   REACTION: R10233
Entry
R10233                      Reaction                               

Name
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
Definition
2 p-Coumaroyl-CoA + Malonyl-CoA + H2O <=> 3 CoA + Bisdemethoxycurcumin + 2 CO2
Equation
2 C00223 + C00083 + C00001 <=> 3 C00010 + C17743 + 2 C00011
Comment
two-step reaction (see R08805+R08807)
Reaction class
RC00004  C00010_C00083  C00010_C00223
Enzyme
Pathway
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K17212  bisdemethoxycurcumin synthase [EC:2.3.1.211]
Other DBs
RHEA: 34806

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