KEGG   ORTHOLOGY: K17225
Entry
K17225                      KO                                     

Name
soxC
Definition
sulfane dehydrogenase subunit SoxC
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00595  Thiosulfate oxidation by SOX complex, thiosulfate => sulfate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17225  soxC; sulfane dehydrogenase subunit SoxC
Other DBs
RN: R10151
COG: COG2041
Genes
PBC: CD58_18890
MSQ: BKP64_06070
MARA: D0851_07300(soxC)
KIM: G3T16_11185(soxC)
MCA: MCA1504
METU: GNH96_09150(soxC)
MAH: MEALZ_1453
MBUR: EQU24_13360(soxC)
MMAI: sS8_0590
MMOB: F6R98_06950(soxC)
TCX: Tcr_0156
HTR: EPV75_01065(soxC)
THIG: FE785_00695(soxC)
GHL: GM160_08825(soxC)
NCU: F0U83_06345(soxC)
RFO: REIFOR_02316(soxC)
LLP: GH975_09735(soxC)
SVA: SVA_0306
REH: H16_A3572(soxC) H16_B2222(h16_B2222)
CNC: CNE_1c35220(soxC) CNE_2c22000(soxC)
CGD: CR3_2734(soxC)
COX: E0W60_27010(soxC)
BTD: BTI_5284
BCN: Bcen_1238
BCJ: BCAS0416
BCEO: I35_7458
BCT: GEM_4760
BCED: DM42_6977
BSEM: WJ12_18425
BGO: BM43_5312
BUL: BW21_4933
BPH: Bphy_7230
BFN: OI25_52
PARB: CJU94_14805(soxC)
PHS: C2L64_44075(soxC)
PTER: C2L65_41440(soxC)
PGP: CUJ91_27965(soxC)
PCJ: CUJ87_30475(soxC)
PTS: CUJ90_09220(soxC)
PMEG: FNZ07_11255(soxC)
PNU: Pnuc_0801
PPNO: DA70_17180
PPNM: LV28_13570
PPUL: RO07_07510
PSPU: NA29_03390
PAPI: SG18_07950
PAND: DRB87_22060(soxC)
PFIB: PI93_023640(soxC)
LIMN: HKT17_06680(soxC)
PUD: G9Q38_09580(soxC)
POL: Bpro_2631
POS: DT070_18170(soxC)
POO: F7R28_12415(soxC)
ACRA: BSY15_3140
VBO: CKY39_30945(soxC)
CTES: O987_17370
COF: FOZ74_01820(soxC)
RTA: Rta_13780
HYB: Q5W_03635
HYC: E5678_10650(soxC)
HPSE: HPF_06265
DIH: G7047_06245(soxC)
SIMP: C6571_14190(soxC)
MELA: C6568_08805(soxC)
METP: C1M51_13755(soxC) C1M51_15810(soxC) C1M51_17260(soxC)
MMS: mma_0446(soxC)
HEE: hmeg3_11220(soxC)
LCH: Lcho_3784
TIN: Tint_2300
THI: THI_2673
SNN: EWH46_01815(soxC)
XYK: GT347_19100(soxC)
OTR: OTERR_06900(sorA)
DAR: Daro_3134
DEY: HYN24_04355(soxC)
ATW: C0099_11285(soxC)
ACOM: CEW83_09830(soxC)
AZR: CJ010_06855(soxC)
AZQ: G3580_13960(soxC)
BPRC: D521_0985
SUA: Saut_2096
SULN: FJR47_09455(soxC)
SULG: FJR48_00370(soxC)
SULC: CVO_09755(soxC)
ABU: Abu_0565(soxC)
ASK: EI285_02175(soxC)
AHS: AHALO_0635(soxC)
AMAR: AMRN_0695(soxC)
ATP: ATR_1124(soxC)
ACAA: ACAN_0715(soxC)
AELL: AELL_0706(soxC)
AAQI: AAQM_0612(soxC)
APOC: APORC_1665(soxC)
HBV: ABIV_1385(soxC)
HEBR: AEBR_1635(soxC)
PACO: AACT_0809(soxC)
ARC: ABLL_0686
SHAL: SHALO_2482
SUN: SUN_0049
ADE: Adeh_2286
NIY: FQ775_21010(soxC)
ORM: HTY61_03410(soxC)
RHT: NT26_2612(soxC)
BJA: bll6121 blr3516(soxC)
BRA: BRADO3184
BRS: S23_18000
AOL: S58_14050 S58_44020(soxC)
BRK: CWS35_28110(soxC)
BOT: CIT37_36635(soxC)
BRQ: CIT40_11185(soxC) CIT40_24485(soxC)
BGQ: X265_02710(soxC) X265_11880(soxC)
BGZ: XH91_02900(soxC) XH91_07665(soxC) XH91_10885(soxC) XH91_21960(soxC)
BSYM: CIT39_10295(soxC) CIT39_23480(soxC)
BBET: F8237_24090(soxC)
RPA: RPA4464(soxC)
RPB: RPB_4368
RPD: RPD_4252
RPE: RPE_3072
RPT: Rpal_4957
NWI: Nwi_2988
NHA: Nham_1093
OCA: OCAR_5180
OCG: OCA5_c27880(sox)
OCO: OCA4_c27870(sox)
BOS: BSY19_752
VGO: GJW-30_1_01697(yedY_3)
XAU: Xaut_1518
AZC: AZC_3167
SNO: Snov_0968
ANC: GBB76_12405(soxC)
MEX: Mext_3339
MCH: Mchl_3664
MPO: Mpop_4161
MET: M446_0148
META: Y590_17325
METD: C0214_07160(soxC) C0214_09205(soxC)
METI: DK427_08865(soxC)
MMES: MMSR116_16045(soxC)
HDN: Hden_1146
BLAG: BLTE_06840(soxC)
MTW: CQW49_22135(soxC)
BRN: D1F64_10965(soxC)
HDI: HDIA_3888
SIL: SPO0998(soxC)
RUA: D1823_09085(soxC)
RDE: RD1_1516(soxC)
RLI: RLO149_c031830(soxC)
RPON: G3256_14750(soxC)
PDE: Pden_4155
PARU: CYR75_11920(soxC)
PARS: DRW48_07285(soxC)
PPAN: ESD82_03385(soxC) ESD82_08190(soxC)
PSF: PSE_1362(soxC)
PGA: PGA1_c12470(soxC)
PGL: PGA2_c12450(soxC)
PGD: Gal_02158
PHP: PhaeoP97_01243(soxC)
PPIC: PhaeoP14_01166(soxC)
PHQ: D1820_02265(soxC)
OTM: OSB_13240
OCT: FTO60_10300(soxC)
LEJ: ETW24_08460(soxC)
LAQU: R2C4_10305(soxC) R2C4_12625(soxC)
PTP: RCA23_c17360(soxC)
CEH: CEW89_07105(soxC)
MALG: MALG_03481
RSU: NHU_02675(soxC)
RHC: RGUI_3430
LABR: CHH27_14120(soxC)
LABP: FJ695_08775(soxC)
YPAC: CEW88_16485(soxC)
SULZ: C1J03_15075(soxC)
SULI: C1J05_07895(soxC)
ROM: EI983_17025(soxC)
RBG: BG454_05025(soxC)
SAGU: CDO87_03820(soxC)
THAA: CFI11_15410(soxC)
SALO: EF888_14340(soxC)
SEDI: EBB79_03320(soxC)
PSEB: EOK75_07810(soxC)
OCD: FHY55_04240(soxC)
SIW: GH266_01565(soxC)
PAED: G5B38_17680(soxC)
MALU: KU6B_10810(soxC)
TGL: HFZ77_05210(soxC)
THAS: C6Y53_05115(soxC)
FAQ: G5B39_08780(soxC)
ACR: Acry_3041
TII: DY252_12645(soxC)
PHR: C6569_08455(soxC)
PSTG: E8M01_30425(soxC)
HTL: HPTL_0809(soxC)
BGY: BGLY_3060
LPIL: LIP_0620
SVE: SVEN_6964
SLX: SLAV_33915(yedY2)
RXY: Rxyl_2351
CTHE: Chro_1585
TTH: TT_C1046(soxC)
TTJ: TTHA1411
TAQ: TO73_0521
MRB: Mrub_2867
GBA: J421_1807
CPI: Cpin_0340
CHIH: GWR21_17390(soxC)
MUH: HYN43_007160(soxC)
MRUB: DEO27_030730(soxC)
OLI: FKG96_21385(soxC)
CHU: CHU_0561(soxC)
DFE: Dfer_1615
SLI: Slin_2735
SPIK: EXU85_21760(soxC)
SPIB: G8759_32395(soxC)
RUP: DTQ70_12505(soxC)
FAE: FAES_1990
NJA: NSJP_3282
TON: TON_0301
THS: TES1_0082
CMA: Cmaq_1480
VDI: Vdis_1876
VMO: VMUT_0310
 » show all
Reference
  Authors
Zander U, Faust A, Klink BU, de Sanctis D, Panjikar S, Quentmeier A, Bardischewsky F, Friedrich CG, Scheidig AJ
  Title
Structural basis for the oxidation of protein-bound sulfur by the sulfur cycle molybdohemo-enzyme sulfane dehydrogenase SoxCD.
  Journal
J Biol Chem 286:8349-60 (2011)
DOI:10.1074/jbc.M110.193631

KEGG   ENZYME: 1.8.2.6
Entry
EC 1.8.2.6                  Enzyme                                 

Name
S-disulfanyl-L-cysteine oxidoreductase;
SoxCD;
sulfur dehydrogenase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a cytochrome as acceptor
Sysname
[SoxY protein]-S-disulfanyl-L-cysteine:cytochrome-c oxidoreductase
Reaction(IUBMB)
[SoxY protein]-S-disulfanyl-L-cysteine + 6 ferricytochrome c + 3 H2O = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 6 ferrocytochrome c + 6 H+ [RN:R11971]
Reaction(KEGG)
R11971
Substrate
[SoxY protein]-S-disulfanyl-L-cysteine [CPD:C21814];
ferricytochrome c [CPD:C00125];
H2O [CPD:C00001]
Product
[SoxY protein]-S-sulfosulfanyl-L-cysteine [CPD:C21815];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. The enzyme from the bacterium Paracoccus pantotrophus contains a molybdoprotein component and a diheme c-type cytochrome component. The enzyme successively oxidizes the outer sulfur atom in [SoxY protein]-S-disulfanyl-L-cysteine, using three water molecules and forming [SoxY protein]-S-sulfosulfanyl-L-cysteine. During the process, six electrons are transferred to the electron chain via cytochrome c.
History
EC 1.8.2.6 created 2018
Pathway
ec00920  Sulfur metabolism
Orthology
K22622  S-disulfanyl-L-cysteine oxidoreductase SoxD
Genes
LYJ: FKV23_07985
PBC: CD58_18895
MSQ: BKP64_06065
MARA: D0851_07305
KIM: G3T16_11190
METU: GNH96_09145
MAH: MEALZ_1454
MBUR: EQU24_13355
MMAI: sS8_0589
MMOB: F6R98_06955
TCX: Tcr_0157
TEE: Tel_16370
RFO: REIFOR_02317(soxD)
REH: H16_A3571(soxD) H16_B2221(h16_B2221)
RME: Rmet_6117(copJ)
CGD: CR3_2733
BTD: BTI_5283
BCN: Bcen_1239
BCJ: BCAS0417
BCEO: I35_7459
BCT: GEM_4759
BCED: DM42_6978
BSEM: WJ12_18430
BGO: BM43_5313
BUL: BW21_4932
BPH: Bphy_7231
BFN: OI25_51
PNU: Pnuc_0802
PPNO: DA70_17185
PPNM: LV28_13565
PPUL: RO07_07505
PSPU: NA29_03385
PAPI: SG18_07945
LMIR: NCTC12852_01955(cyt)
BPAR: BN117_2482
BPA: BPP1578
BBR: BB2656
BPT: Bpet4582
POL: Bpro_2630
ACRA: BSY15_3141
CTES: O987_17365
RTA: Rta_13790
HYB: Q5W_03640
HPSE: HPF_06270(cyt)
MMS: mma_0447
LCH: Lcho_3783
TIN: Tint_2299
THI: THI_2672
SLT: Slit_0645
NIM: W01_26030
DAR: Daro_3133
AZA: AZKH_3911
BPRC: D521_0984
SUA: Saut_2097
SULC: CVO_09760
ABU: Abu_0566(soxD)
AHS: AHALO_0636(soxD)
AMAR: AMRN_0696(soxD)
ATP: ATR_1125(soxD)
ACAA: ACAN_0716(soxD)
AELL: AELL_0707(soxD)
AAQI: AAQM_0613(soxD)
APOC: APORC_1664(soxD)
HBV: ABIV_1384(soxD)
HEBR: AEBR_1634(soxD)
PACO: AACT_0810(soxD)
ARC: ABLL_0687
SHAL: SHALO_2481
SUN: SUN_0050
ADE: Adeh_2285
MES: Meso_2891
AGC: BSY240_3519(soxD)
RHT: NT26_2611(soxD)
BJA: bll6120 blr3517(soxD)
BRA: BRADO3185
BRS: S23_18010
AOL: S58_14060 S58_44010(soxD)
RPA: RPA4463
RPB: RPB_4367
RPD: RPD_4251
RPE: RPE_3071
RPT: Rpal_4956
NWI: Nwi_2987
NHA: Nham_1094
OCA: OCAR_5181
BOS: BSY19_753
XAU: Xaut_1517
AZC: AZC_3166
SNO: Snov_0967
MEX: Mext_3340
MCH: Mchl_3665
MPO: Mpop_4162
MET: M446_0147
MNO: Mnod_8678
META: Y590_17320
HDN: Hden_1145
BLAG: BLTE_06850(soxD)
HDI: HDIA_3887
SIL: SPO0999(soxD)
RDE: RD1_1517(soxD)
RLI: RLO149_c031820(soxD4)
PDE: Pden_4156
PSF: PSE_1361(soxD) PSE_3088
PGA: PGA1_c12480(soxD2)
PGL: PGA2_c12460(soxD2)
PGD: Gal_02157
PHP: PhaeoP97_01244(soxD2)
PPIC: PhaeoP14_01167(soxD2)
OTM: OSB_13250
PTP: RCA23_c17350(soxD2)
MALG: MALG_03480
RSU: NHU_02674(soxD)
RHC: RGUI_3431
MALU: KU6B_10820
SPHI: TS85_14125
SINB: SIDU_17655
GXL: H845_1325
ASZ: ASN_973
MGRY: MSR1_10470(petJ)
HTL: HPTL_0810(soxD)
DFC: DFI_15365
TRA: Trad_2909
TTH: TT_C1045
TTJ: TTHA1410
TAQ: TO73_0522
MRB: Mrub_2868
ABAS: ACPOL_1925
SUS: Acid_2558
GAU: GAU_2319
CPI: Cpin_0341
CHU: CHU_0560(soxD)
DFE: Dfer_1616
SLI: Slin_2734
FAE: FAES_1991
NJA: NSJP_3283
 » show all
Reference
1  [PMID:11425697]
  Authors
Friedrich CG, Rother D, Bardischewsky F, Quentmeier A, Fischer J
  Title
Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?
  Journal
Appl Environ Microbiol 67:2873-82 (2001)
DOI:10.1128/AEM.67.7.2873-2882.2001
Reference
2  [PMID:15865447]
  Authors
Bardischewsky F, Quentmeier A, Rother D, Hellwig P, Kostka S, Friedrich CG
  Title
Sulfur dehydrogenase of Paracoccus pantotrophus: the heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
  Journal
Biochemistry 44:7024-34 (2005)
DOI:10.1021/bi047334b
Reference
3  [PMID:28257465]
  Authors
Grabarczyk DB, Berks BC
  Title
Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
  Journal
PLoS One 12:e0173395 (2017)
DOI:10.1371/journal.pone.0173395
Other DBs
ExplorEnz - The Enzyme Database: 1.8.2.6
IUBMB Enzyme Nomenclature: 1.8.2.6
ExPASy - ENZYME nomenclature database: 1.8.2.6
BRENDA, the Enzyme Database: 1.8.2.6

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