| Entry |
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| Name |
tryprostatin B 6-hydroxylase;
ftmC (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
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| Reaction(IUBMB) |
tryprostatin B + [reduced NADPH---hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH---hemoprotein reductase] + H2O [RN: R10321]
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| Reaction(KEGG) |
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| Substrate |
tryprostatin B [CPD: C20512];
[reduced NADPH---hemoprotein reductase] [CPD: C03024];
O2 [CPD: C00007]
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| Product |
6-hydroxytryprostatin B [CPD: C20513];
[oxidized NADPH---hemoprotein reductase] [CPD: C03161];
H2O [CPD: C00001]
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| Comment |
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
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| History |
EC 1.14.14.118 created 2013 as EC 1.14.13.176, transferred 2018 to EC 1.14.14.118
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K17475 | tryprostatin B 6-hydroxylase |
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| Genes |
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| Reference |
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| Authors |
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H |
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| Title |
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus. |
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| Journal |
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| Sequence |
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| Other DBs |
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