KEGG   ORTHOLOGY: K17486
Entry
K17486                      KO                                     

Name
dmdA
Definition
dimethylsulfoniopropionate demethylase [EC:2.1.1.269]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17486  dmdA; dimethylsulfoniopropionate demethylase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.269  dimethylsulfoniopropionate demethylase
     K17486  dmdA; dimethylsulfoniopropionate demethylase
Other DBs
RN: R10333
Genes
GAI: IMCC3135_15030(dmdA)
HOE: IMCC20628_01219
SIL: SPO1913(dmdA)
SIT: TM1040_1444
RMB: K529_006360(dmdA)
JAN: Jann_2379
RDE: RD1_2288
RLI: RLO149_c022350
RPON: G3256_07845
DSH: Dshi_2320(gcvT1)
OTM: OSB_12930(dmdA)
LMD: METH_10405(dmdA)
MALG: MALG_05026
LABR: CHH27_18755(dmdA)
TOM: BWR18_06790(dmdA)
RMM: ROSMUCSMR3_03150(dmdA)
 » show all
Reference
  Authors
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN
  Title
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
  Journal
Protein Sci 21:289-98 (2012)
DOI:10.1002/pro.2015
  Sequence

KEGG   ENZYME: 2.1.1.269
Entry
EC 2.1.1.269                Enzyme                                 

Name
dimethylsulfoniopropionate demethylase;
dmdA (gene name);
dimethylsulfoniopropionate-dependent demethylase A
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
Reaction(IUBMB)
S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate [RN:R10333]
Reaction(KEGG)
R10333
Substrate
S,S-dimethyl-beta-propiothetin [CPD:C04022];
tetrahydrofolate [CPD:C00101]
Product
3-(methylsulfanyl)propanoate [CPD:C08276];
5-methyltetrahydrofolate [CPD:C00440]
Comment
The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].
History
EC 2.1.1.269 created 2013
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K17486  dimethylsulfoniopropionate demethylase
Genes
GAI: IMCC3135_15030(dmdA)
HOE: IMCC20628_01219
SIL: SPO1913(dmdA)
SIT: TM1040_1444
RMB: K529_006360(dmdA)
JAN: Jann_2379
RDE: RD1_2288
RLI: RLO149_c022350
RPON: G3256_07845
DSH: Dshi_2320(gcvT1)
OTM: OSB_12930(dmdA)
LMD: METH_10405(dmdA)
MALG: MALG_05026
LABR: CHH27_18755(dmdA)
TOM: BWR18_06790(dmdA)
RMM: ROSMUCSMR3_03150(dmdA)
 » show all
Reference
1  [PMID:9396840]
  Authors
Jansen M, Hansen TA
  Title
Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria.
  Journal
Arch Microbiol 169:84-7 (1998)
DOI:10.1007/s002030050545
Reference
2  [PMID:18849431]
  Authors
Reisch CR, Moran MA, Whitman WB
  Title
Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique  and Silicibacter pomeroyi.
  Journal
J Bacteriol 190:8018-24 (2008)
DOI:10.1128/JB.00770-08
  Sequence
[pub:SAR11_0246] [sil:SPO1913]
Reference
3  [PMID:22162093]
  Authors
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN
  Title
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
  Journal
Protein Sci 21:289-98 (2012)
DOI:10.1002/pro.2015
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.269
IUBMB Enzyme Nomenclature: 2.1.1.269
ExPASy - ENZYME nomenclature database: 2.1.1.269
BRENDA, the Enzyme Database: 2.1.1.269

KEGG   REACTION: R10333
Entry
R10333                      Reaction                               

Name
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
Definition
S,S-Dimethyl-beta-propiothetin + Tetrahydrofolate <=> 3-(Methylthio)propanoate + 5-Methyltetrahydrofolate
Equation
Reaction class
RC00113  C00101_C00440
RC00347  C04022_C08276
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K17486  dimethylsulfoniopropionate demethylase [EC:2.1.1.269]
Other DBs
RHEA: 35470

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