KEGG   ORTHOLOGY: K17643Help
Entry
K17643                      KO                                     

Name
HYPC
Definition
noranthrone monooxygenase [EC:1.13.12.20]
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17643  HYPC; noranthrone monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.20  noranthrone monooxygenase
     K17643  HYPC; noranthrone monooxygenase
BRITE hierarchy
Other DBs
RN: R10224
Genes
PAN: PODANSg8557
AFV: AFLA_139400
TaxonomyKoalaUniProt
Reference
  Authors
Ehrlich KC, Li P, Scharfenstein L, Chang PK
  Title
HypC, the anthrone oxidase involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 76:3374-7 (2010)
DOI:10.1128/AEM.02495-09
  Sequence

KEGG   ENZYME: 1.13.12.20Help
Entry
EC 1.13.12.20               Enzyme                                 

Name
noranthrone monooxygenase;
norsolorinate anthrone oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
BRITE hierarchy
Sysname
norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
Reaction(IUBMB)
norsolorinic acid anthrone + O2 = norsolorinic acid + H2O [RN:R10224]
Reaction(KEGG)
Substrate
norsolorinic acid anthrone [CPD:C20453];
O2 [CPD:C00007]
Product
norsolorinic acid [CPD:C20452];
H2O [CPD:C00001]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.13.12.20 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K17643  noranthrone monooxygenase
Genes
PAN: PODANSg8557
AFV: AFLA_139400
Taxonomy
Reference
1  [PMID:20348292]
  Authors
Ehrlich KC, Li P, Scharfenstein L, Chang PK
  Title
HypC, the anthrone oxidase involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 76:3374-7 (2010)
DOI:10.1128/AEM.02495-09
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.20
IUBMB Enzyme Nomenclature: 1.13.12.20
ExPASy - ENZYME nomenclature database: 1.13.12.20
BRENDA, the Enzyme Database: 1.13.12.20

KEGG   REACTION: R10224Help
Entry
R10224                      Reaction                               

Name
norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
Definition
Norsolorinic acid anthrone + Oxygen <=> Norsolorinic acid + H2O
Equation
Reaction class
RC01658  C20452_C20453
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Orthology
K17643  noranthrone monooxygenase [EC:1.13.12.20]
Other DBs
RHEA: 35194

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