KEGG   ORTHOLOGY: K17644Help
Entry
K17644                      KO                                     

Name
aflD, nor-1
Definition
norsolorinic acid ketoreductase [EC:1.1.1.349]
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17644  aflD, nor-1; norsolorinic acid ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.349  norsolorinic acid ketoreductase
     K17644  aflD, nor-1; norsolorinic acid ketoreductase
BRITE hierarchy
Other DBs
RN: R10309
Genes
QSU: 111983631 111989788 112014326
SMP: SMAC_00337
PAN: PODANSg8549 PODANSg8566
TTT: THITE_2089433 THITE_2147584
MGR: MGG_10910
TMN: UCRPA7_6053 UCRPA7_8840
FVR: FVEG_09885 FVEG_13322
FOX: FOXG_15212
NHE: NECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
TRE: TRIREDRAFT_103113 TRIREDRAFT_105884
CMT: CCM_08014
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400)
AG: AAA58798(nor-1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7993094
  Authors
Trail F, Chang PK, Cary J, Linz JE
  Title
Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 60:4078-85 (1994)
  Sequence
Reference
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)

KEGG   ENZYME: 1.1.1.349Help
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU: 111983631 111989788 112014326
SMP: SMAC_00337
PAN: PODANSg8549 PODANSg8566
TTT: THITE_2089433 THITE_2147584
MGR: MGG_10910
TMN: UCRPA7_6053 UCRPA7_8840
FVR: FVEG_09885 FVEG_13322
FOX: FOXG_15212
NHE: NECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
TRE: TRIREDRAFT_103113 TRIREDRAFT_105884
CMT: CCM_08014
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400)
 » show all
Taxonomy
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus  parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349

KEGG   REACTION: R10309Help
Entry
R10309                      Reaction                               

Name
(1'S)-averantin:NADP+ oxidoreductase
Definition
(1'S)-Averantin + NADP+ <=> Norsolorinic acid + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC01491  C20452_C20499
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Orthology
K17644  norsolorinic acid ketoreductase [EC:1.1.1.349]
Other DBs
RHEA: 35450

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