KEGG   ORTHOLOGY: K17644
Entry
K17644                      KO                                     

Name
AFLD, NOR-1
Definition
norsolorinic acid ketoreductase [EC:1.1.1.349]
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17644  AFLD, NOR-1; norsolorinic acid ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.349  norsolorinic acid ketoreductase
     K17644  AFLD, NOR-1; norsolorinic acid ketoreductase
Other DBs
RN: R10309
COG: COG1028
GO: 0140393
Genes
QSU: 111983631
PAN: PODANSg8566
TMN: UCRPA7_6053
NHE: NECHADRAFT_19049 NECHADRAFT_44851
TRE: TRIREDRAFT_105884
TRR: M419DRAFT_7213
VAL: VDBG_02925 VDBG_06335
VDA: VDAG_03485
CFJ: CFIO01_09694 CFIO01_11244
ELA: UCREL1_771 UCREL1_8646
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400) ANI_1_2226024(An02g01090)
AG: AAA58798(nor-1)
 » show all
Reference
PMID:7993094
  Authors
Trail F, Chang PK, Cary J, Linz JE
  Title
Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 60:4078-85 (1994)
DOI:10.1128/AEM.60.11.4078-4085.1994
  Sequence
Reference
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999

KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU: 111983631
PAN: PODANSg8566
TMN: UCRPA7_6053
NHE: NECHADRAFT_19049 NECHADRAFT_44851
TRE: TRIREDRAFT_105884
TRR: M419DRAFT_7213
VAL: VDBG_02925 VDBG_06335
VDA: VDAG_03485
CFJ: CFIO01_09694 CFIO01_11244
ELA: UCREL1_771 UCREL1_8646
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400) ANI_1_2226024(An02g01090)
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349

KEGG   REACTION: R10309
Entry
R10309                      Reaction                               

Name
(1'S)-averantin:NADP+ oxidoreductase
Definition
(1'S)-Averantin + NADP+ <=> Norsolorinic acid + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC01491  C20452_C20499
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Orthology
K17644  norsolorinic acid ketoreductase [EC:1.1.1.349]
Other DBs
RHEA: 35450

DBGET integrated database retrieval system