KEGG   ORTHOLOGY: K17647Help
Entry
K17647                      KO                                     

Name
VRDA
Definition
versiconal hemiacetal acetate reductase [EC:1.1.1.353]
Pathway
ko00254  Aflatoxin biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17647  VRDA; versiconal hemiacetal acetate reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.353  versiconal hemiacetal acetate reductase
     K17647  VRDA; versiconal hemiacetal acetate reductase
BRITE hierarchy
Other DBs
RN: R09756 R10399 R10400
Genes
AOR: AO090120000002
AFV: AFLA_090030
AG: BAH24200(vrdA)
TaxonomyKoalaUniProt
Reference
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005
  Sequence

KEGG   ENZYME: 1.1.1.353Help
Entry
EC 1.1.1.353                Enzyme                                 

Name
versiconal hemiacetal acetate reductase;
VHA reductase;
VHA reductase I;
VHA reductase II;
vrdA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
versiconol-acetate:NADP+ oxidoreductase
Reaction(IUBMB)
(1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+ [RN:R09756];
(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+ [RN:R10399];
(3) versiconol + NADP+ = versiconal + NADPH + H+ [RN:R10400]
Reaction(KEGG)
Substrate
versicolorone [CPD:C20504];
NADP+ [CPD:C00006];
versiconol acetate [CPD:C20506];
versiconol [CPD:C20508]
Product
1'-hydroxyversicolorone [CPD:C20503];
NADPH [CPD:C00005];
H+ [CPD:C00080];
versiconal hemiacetal acetate [CPD:C20505];
versiconal [CPD:C20507]
Comment
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
History
EC 1.1.1.353 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K17647  versiconal hemiacetal acetate reductase
Genes
AOR: AO090120000002
AFV: AFLA_090030
Taxonomy
Reference
1  [PMID:16349333]
  Authors
Matsushima K, Ando Y, Hamasaki T, Yabe K
  Title
Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 60:2561-7 (1994)
  Sequence
Reference
2  [PMID:19211038]
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.353
IUBMB Enzyme Nomenclature: 1.1.1.353
ExPASy - ENZYME nomenclature database: 1.1.1.353
BRENDA, the Enzyme Database: 1.1.1.353

KEGG   REACTION: R10400Help
Entry
R10400                      Reaction                               

Name
versiconol:NADP+ oxidoreductase
Definition
Versiconol + NADP+ <=> Versiconal + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC03145  C20507_C20508
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K17647  versiconal hemiacetal acetate reductase [EC:1.1.1.353]
Other DBs
RHEA: 35702

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