KEGG   ORTHOLOGY: K17649
Entry
K17649                      KO                                     

Name
OMTB, dmtA
Definition
demethylsterigmatocystin 6-O-methyltransferase [EC:2.1.1.109]
Pathway
ko00254  Aflatoxin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17649  OMTB, dmtA; demethylsterigmatocystin 6-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.109  demethylsterigmatocystin 6-O-methyltransferase
     K17649  OMTB, dmtA; demethylsterigmatocystin 6-O-methyltransferase
Other DBs
RN: R03112 R10403
GO: 0047145
Genes
PAN: PODANSg8572
PFY: PFICI_09442
PSCO: LY89DRAFT_659800
AOR: AO090026000025
ANG: ANI_1_2158014(An01g00880)
AFV: AFLA_139220
PCS: Pc18g03140
URE: UREG_07660
PNO: SNOG_08160
AALT: CC77DRAFT_1098501
Reference
  Authors
Motomura M, Chihaya N, Shinozawa T, Hamasaki T, Yabe K
  Title
Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 65:4987-94 (1999)
DOI:10.1128/AEM.65.11.4987-4994.1999
  Sequence

KEGG   ENZYME: 2.1.1.109
Entry
EC 2.1.1.109                Enzyme                                 

Name
demethylsterigmatocystin 6-O-methyltransferase;
demethylsterigmatocystin methyltransferase;
O-methyltransferase I
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin [RN:R03112]
Reaction(KEGG)
R03112;
(other) R10403
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-demethylsterigmatocystin [CPD:C03683]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
sterigmatocystin [CPD:C00961]
Comment
Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
History
EC 2.1.1.109 created 1992
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17649  demethylsterigmatocystin 6-O-methyltransferase
Genes
PAN: PODANSg8572
PFY: PFICI_09442
PSCO: LY89DRAFT_659800
AOR: AO090026000025
ANG: ANI_1_2158014(An01g00880)
AFV: AFLA_139220
PCS: Pc18g03140
URE: UREG_07660
PNO: SNOG_08160
AALT: CC77DRAFT_1098501
Reference
1  [PMID:2802602]
  Authors
Yabe K, Ando Y, Hashimoto J, Hamasaki T.
  Title
Two distinct O-methyltransferases in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 55:2172-7 (1989)
DOI:10.1128/AEM.55.9.2172-2177.1989
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.109
IUBMB Enzyme Nomenclature: 2.1.1.109
ExPASy - ENZYME nomenclature database: 2.1.1.109
BRENDA, the Enzyme Database: 2.1.1.109
CAS: 123516-47-2

KEGG   REACTION: R10403
Entry
R10403                      Reaction                               

Name
S-adenosyl-L-methionine:dihydrodemethylsterigmatocystin 6-O-methyltransferase
Definition
S-Adenosyl-L-methionine + Dihydrodemethylsterigmatocystin <=> S-Adenosyl-L-homocysteine + Dihydrosterigmatocystin
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C20444_C20445
Enzyme
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K17649  demethylsterigmatocystin 6-O-methyltransferase [EC:2.1.1.109]

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