KEGG   ORTHOLOGY: K17683
Entry
K17683            Tight     KO                                     
Symbol
CYP2A6
Name
cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Pathway
map00232  Caffeine metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07945  
R08225  
R08324  
R08325  
R08326  
R08327  
R08390  
R08391  
R08392  
R09408  
R09421  
R09423  
R09424  
R09425  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Genes
HSA: 1548(CYP2A6) 1549(CYP2A7)
PTR: 107966456(CYP2A7)
PPS: 100975509(CYP2A7)
GGO: 101146638
PON: 100457048
PPYG: 129019418
MCF: 102122745(CYP2A24)
TGE: 112611969
PTEH: 111554025
Reference
PMID:2726448 (CYP2A6)
  Authors
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR
  Title
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
  Journal
Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907
  Sequence
[hsa:1548]
Reference
PMID:7668294 (CYP2A7)
  Authors
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al.
  Title
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
  Journal
Am J Hum Genet 57:651-60 (1995)
  Sequence
[hsa:1549]
Reference
PMID:12406643
  Authors
Xu C, Goodz S, Sellers EM, Tyndale RF
  Title
CYP2A6 genetic variation and potential consequences.
  Journal
Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (30)   
   KEGG REACTION (16)   
   KEGG RCLASS (14)   
Gene (11)   
   KEGG GENES (10)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (63)   

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