KEGG ORTHOLOGY: K17683

ORTHOLOGY: K17683

Entry

K17683            Tight     KO

Symbol

CYP2A6

Name

cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]

Pathway

map00232

Caffeine metabolism

map00830

Retinol metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map00983

Drug metabolism - other enzymes

map01100

Metabolic pathways

map05204

Chemical carcinogenesis - DNA adducts

map05417

Lipid and atherosclerosis

Reaction

R07000

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07001

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07945

R08225

R08324

R08325

R08326

R08327

R08390

R08391

R08392

R09408

R09421

R09423

R09424

R09425

Disease

H01205

Coumarin resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A6

Genes

HSA:	1548(CYP2A6) 1549(CYP2A7)

PTR:	107966456(CYP2A7)

PPS:	100975509(CYP2A7)

GGO:

101146638

PON:

100457048

PPYG:

129019418

MCF:	102122745(CYP2A24)

TGE:

112611969

PTEH:

111554025

Reference

PMID:2726448 (CYP2A6)

Authors

Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR

Title

Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

Journal

Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907

Sequence

[hsa:1548]

Reference

PMID:7668294 (CYP2A7)

Authors

Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al.

Title

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

Journal

Am J Hum Genet 57:651-60 (1995)

Sequence

[hsa:1549]

Reference

PMID:12406643

Authors

Xu C, Goodz S, Sellers EM, Tyndale RF

Title

CYP2A6 genetic variation and potential consequences.

Journal

Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (30)   
   KEGG REACTION (16)   
   KEGG RCLASS (14)   
Gene (11)   
   KEGG GENES (10)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (63)   

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ORTHOLOGY: K17685

Entry

K17685                      KO

Symbol

CYP2A13

Name

cytochrome P450 family 2 subfamily A13 [EC:1.14.14.1]

Pathway

map00980

Metabolism of xenobiotics by cytochrome P450

map05204

Chemical carcinogenesis - DNA adducts

Reaction

R09406

R09408

R09421

R09423

R09424

R09425

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K17685  CYP2A13; cytochrome P450 family 2 subfamily A13

Genes

HSA:	1553(CYP2A13)

PTR:

101058187

PPS:	100982833(CYP2A13)

GGO:

101127384

PON:

100458875

PPYG:

129020009

NLE:	100579248 115830830

HMH:

116480658

SSYN:

129466953

MCC:	114674219 678689(CYP2A24) 678690(CYP2A23) 702954(CYP2A26) 722086

MCF:	102121341(CYP2A26) 102123758(CYP2A23) 102143277(CYP2A13)

MTHB:

126942025 126942026 126942027

MNI:	105495311 105495313 105495316 105495624

CSAB:

103234718 103234724 103235510

CATY:

105597997 105598000 105598006

PANU:

101000609 101001634 101001995

TGE:	112612112 112617720

MLEU:

105542152 105542563

RRO:	104676095 104676097 104676180

RBB:	108536151 108536152

TFN:	117076048 117086673 117087862 117088591 117091930

PTEH:

111554024

CANG:

105507828 105519195 105519196

CJC:	100399054(CYP2A7)

SBQ:

101046499

CIMI:

108285671(CYP2A6)

ANAN:

105723439(CYP2A6)

LCAT:

PCOQ:

PKL:

EFUS:

TOD:

CCAY:

DCC:	119847020 119847021

TST:	117888569 117888576

CABI:

116833844 116833878

MRV:	120388412 120388413 120388415

CTIG:

APRI:

PRAF:

HCG:

STOW:

EMC:	129343119 129343683

DPOL:

127863877

» show all

Reference

PMID:11016631

Authors

Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X

Title

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Journal

Cancer Res 60:5074-9 (2000)

Sequence

[hsa:1553]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (11)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
   KEGG RCLASS (4)   
Gene (129)   
   KEGG GENES (81)   
   RefGene (43)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (148)   

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