KEGG   ORTHOLOGY: K17685
Entry
K17685                      KO                                     
Symbol
CYP2A13
Name
cytochrome P450 family 2 subfamily A13 [EC:1.14.14.1]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17685  CYP2A13; cytochrome P450 family 2 subfamily A13
Other DBs
RN: R09406 R09408 R09421 R09423 R09424 R09425
Genes
HSA: 1553(CYP2A13)
PTR: 101058187
PPS: 100982833(CYP2A13)
GGO: 101127384
PON: 100458875
NLE: 100579248 115830830
MCC: 114674219 678689(CYP2A24) 678690(CYP2A23) 702954(CYP2A26) 722086
MCF: 102121341(CYP2A26) 102123758(CYP2A23) 102143277(CYP2A13)
MTHB: 126942025 126942026 126942027
CSAB: 103234718 103234724 103235510
PTEH: 111554024
CANG: 105519196
CJC: 100399054(CYP2A6)
SBQ: 101046499
LCAT: 123624295
GVR: 103600499
PKL: 118730245
TOD: 119250434
CTIG: 120316367
STOW: 125424829
 » show all
Reference
  Authors
Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X
  Title
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
  Journal
Cancer Res 60:5074-9 (2000)
  Sequence
[hsa:1553]

KEGG   ORTHOLOGY: K17683
Entry
K17683            Tight     KO                                     
Symbol
CYP2A6
Name
cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Pathway
map00232  Caffeine metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Other DBs
RN: R07000 R07001 R07945 R08225 R08324 R08325 R08326 R08327 R08390 R08391 R08392 R09408 R09421 R09423 R09424 R09425
Genes
HSA: 1548(CYP2A6) 1549(CYP2A7)
PTR: 107966456
PPS: 100975509(CYP2A7)
GGO: 101146638
PON: 100457048
MCF: 102122745(CYP2A24)
TGE: 112611969
PTEH: 111554025
Reference
PMID:2726448 (CYP2A6)
  Authors
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR
  Title
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
  Journal
Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907
  Sequence
[hsa:1548]
Reference
PMID:7668294 (CYP2A7)
  Authors
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al.
  Title
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
  Journal
Am J Hum Genet 57:651-60 (1995)
  Sequence
[hsa:1549]
Reference
  Authors
Xu C, Goodz S, Sellers EM, Tyndale RF
  Title
CYP2A6 genetic variation and potential consequences.
  Journal
Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0

DBGET integrated database retrieval system